Noncytopathic bovine viral diarrhea virus inhibits double-stranded RNA-induced apoptosis and interferon synthesis.

abstract：:Purified nuclei from polyoma-infected mouse (3T3) cells were found to be greatly reduced in their ability to synthesize viral DNA in vitro when compared with a crude system consisting of an unfractionated hypotonic lysate of the infected cells. The synthetic capacity of the nuclei could be fully reconstituted when a h...

journal_title：Journal of virology

authors： Francke B,Hunter T

更新日期：1975-01-01 00:00:00

abstract：:p21((WAF1/SDII/CIP1)) (p21) arrests cell growth by inhibiting cyclin-depend kinases. To explore the potential of using p21 for the gene therapy of cervical cancer, we infected human papillomavirus (HPV)-positive cervical cancer cells (HeLa, SiHa, and Z172) and HPV-negative cervical cancer cells (C33A) with recombinant...

journal_title：Journal of virology

authors： Tsao YP,Huang SJ,Chang JL,Hsieh JT,Pong RC,Chen SL

更新日期：1999-06-01 00:00:00

abstract：:To assess the role of naturally occurring basic amino acid substitutions in the V3 loop of human immunodeficiency virus type 1 (HIV-1) subtype E on viral coreceptor usage and cell tropism, we have constructed a panel of chimeric viruses with mutant V3 loops of HIV-1 subtype E in the genetic background of HIV-1LAI. The...

journal_title：Journal of virology

authors： Kato K,Sato H,Takebe Y

更新日期：1999-07-01 00:00:00

abstract：:Due to the biological significance of the carbohydrate component of the human immunodeficiency virus type 1 (HIV-1) glycoproteins in viral pathogenesis, the glycosylation step constitutes an attractive target for anti-HIV therapy. Cyanovirin N (CV-N), which specifically targets the high-mannose (HM) glycans on gp120, ...

journal_title：Journal of virology

authors： Witvrouw M,Fikkert V,Hantson A,Pannecouque C,O'keefe BR,McMahon J,Stamatatos L,de Clercq E,Bolmstedt A

更新日期：2005-06-01 00:00:00

abstract：:Bovine herpesvirus 1 (BoHV-1) is an alphaherpesvirus that causes disease in cattle populations worldwide. Sphingomyelin (SM) is the most abundant sphingolipid in the mammalian cell membrane, where it preferentially associates with cholesterol to form lipid raft domains. SM is a substrate for the lysosome-resident enzy...

journal_title：Journal of virology

authors： Pastenkos G,Miller JL,Pritchard SM,Nicola AV

更新日期：2019-02-19 00:00:00

abstract：:The morphology of Safferman's virus of blue-green algae (phycovirus LPP-1) has been studied by electron microscopy and physicochemical methods. The virion has a short (100 to 200 A long, 150 A in diameter) forked tail, with an outer sheath, an inner core, and a capital attached to one of the vertices of a polyhedral h...

journal_title：Journal of virology

authors： Luftig R,Haselkorn R

更新日期：1967-04-01 00:00:00

abstract：UNLABELLED:Three waves of human infection with H7N9 influenza viruses have concluded to date, but only viruses within the first wave (isolated between March and September 2013) have been extensively studied in mammalian models. While second- and third-wave viruses remain closely linked phylogenetically and antigenicall...

journal_title：Journal of virology

authors： Belser JA,Creager HM,Sun X,Gustin KM,Jones T,Shieh WJ,Maines TR,Tumpey TM

更新日期：2016-04-14 00:00:00

abstract：:The RNA produced in vivo from bacteriophage phiX174 DNA has been analyzed by polyacrylamide-agarose gel electrophoresis and sedimentation in dimethyl sulfoxide gradients, and the results of Hayashi and Hayashi (1970) have been confirmed and extended. An efficient procedure for recovery of RNA from gels, followed by a ...

journal_title：Journal of virology

authors： Clements JB,Sinsheimer RL

更新日期：1975-01-01 00:00:00

abstract：:Molecularly defined vaccine formulations capable of inducing antiviral CD8+ T-cell-specific immunity in a manner compatible with human delivery are limited. Few molecules achieve this target without the support of an appropriate immunological adjuvant. In this study, we investigate the potential of totally synthetic p...

journal_title：Journal of virology

authors： Zhang X,Issagholian A,Berg EA,Fishman JB,Nesburn AB,BenMohamed L

更新日期：2005-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a prominent risk factor for the development of hepatocellular carcinoma (HCC). Similar to most solid tumors, HCCs are believed to contain poorly differentiated cancer stem cell-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. In these studies, we...

journal_title：Journal of virology

authors： Ali N,Allam H,May R,Sureban SM,Bronze MS,Bader T,Umar S,Anant S,Houchen CW

更新日期：2011-12-01 00:00:00

abstract：:We characterized the cellular immune response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in 12- to 14-month-old BALB/c mice, a model that mimics features of the human disease. Following intranasal administration, the virus replicated in the lungs, with peak titers on day 2 postinfection. Enh...

journal_title：Journal of virology

authors： Chen J,Lau YF,Lamirande EW,Paddock CD,Bartlett JH,Zaki SR,Subbarao K

更新日期：2010-02-01 00:00:00

abstract：:Treatment of influenza virus and its purified hemagglutining with glycosidases from Diplococcus pneumoniae, which included beta-galactosidase, beta-N-acetylglucosminidase, and endoglycosidase D, released amino and neutral sugars from the virus and these as well as large oligosaccharides from the purified hemagglutinin...

journal_title：Journal of virology

authors： Collins JK,Knight CA

更新日期：1978-07-01 00:00:00

abstract：:A mutation (asparagine 815 to serine 815) was introduced into the herpes simplex virus type 1 (HSV-1) DNA polymerase (pol). The HSV-1 pol enzyme in lysates of Saccharomyces cerevisiae cells expressing the mutant protein showed increased resistance to acyclovir triphosphate and increased sensitivity to phosphonoacetate...

journal_title：Journal of virology

authors： Matthews JT,Carroll RD,Stevens JT,Haffey ML

更新日期：1989-11-01 00:00:00

abstract：:In a study of the evolution and distribution of avian retroviruses, we found avian sarcoma and leukosis virus (ASLV) gag genes in 26 species of galliform birds from North America, Central America, eastern Europe, Asia, and Africa. Nineteen of the 26 host species from whom ASLVs were sequenced were not previously known...

journal_title：Journal of virology

authors： Dimcheff DE,Drovetski SV,Krishnan M,Mindell DP

更新日期：2000-05-01 00:00:00

abstract：:The genome of the defective interfering (DI) mouse hepatitis virus DI-a carries a large open reading frame (ORF) consisting of ORF1a, ORF1b, and nucleocapsid sequences. To test whether this fusion ORF is important for DI virus replication, we constructed derivatives of the DI-a genome in which the reading frame was tr...

journal_title：Journal of virology

authors： de Groot RJ,van der Most RG,Spaan WJ

更新日期：1992-10-01 00:00:00

abstract：:Polymerase basic protein 2 (PB2), a component of the influenza virus polymerase complex, when expressed alone from cloned cDNA in the absence of other influenza virus proteins, is transported into the nucleus. In this study, we have examined the nuclear translocation signal of PB2 by making deletions and mutations in ...

journal_title：Journal of virology

authors： Mukaigawa J,Nayak DP

更新日期：1991-01-01 00:00:00

abstract：:Lymphomas induced by the Abelson murine leukemia virus (A-MuLV) were examined for the expression of biochemical and biological markers associated with A-MuLV transformation before and after in vivo growth in genetically distinguishable host mice. Although all tumors and clonal lines derived from them initially express...

journal_title：Journal of virology

authors： Grunwald DJ,Dale B,Dudley J,Lamph W,Sugden B,Ozanne B,Risser R

更新日期：1982-07-01 00:00:00

abstract：:Primary RNA transcripts from the human immunodeficiency virus type 1 (HIV-1) are processed into mature mRNA by a complex series of splicing events. Viral structural proteins and reverse transcriptase are translated from unspliced or singly spliced transcripts. Proteins which control virus replication, including tat, r...

journal_title：Journal of virology

authors： Robert-Guroff M,Popovic M,Gartner S,Markham P,Gallo RC,Reitz MS

更新日期：1990-07-01 00:00:00

abstract：:By pretreating simian virus 40-infected BSC-1 cells with glucosamine, [(3)H]uridine labeling of both cellular and viral RNA can be halted instantaneously by addition of cold uridine. We have studied the fate of pulse-labeled viral RNA from cells at 45 h postinfection under these conditions. During a 5-min period of la...

journal_title：Journal of virology

authors： Chiu NH,Radonovich MF,Thoren MM,Salzman NP

更新日期：1978-11-01 00:00:00

abstract：:Sections of normal and diseased brain and kidney tissues were screened for the presence of JC virus (JCV) DNA by using the polymerase chain reaction. As expected, all samples obtained from patients with progressive multifocal leukoencephalopathy (PML) tested positive when multiple JCV-specific primer and probe combina...

journal_title：Journal of virology

authors： White FA 3rd,Ishaq M,Stoner GL,Frisque RJ

更新日期：1992-10-01 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) establishes a latent infection in sensory ganglionic neurons of cattle. During a latent infection, a single latency-related (LR) transcript is expressed. This observation suggested that DNA sequences in the LR promoter are positively regulated by neural cell type factors. The regulation of...

journal_title：Journal of virology

authors： Bratanich AC,Jones CJ

更新日期：1992-10-01 00:00:00

abstract：:Disulfide bonds reportedly stabilize the capsids of several viruses, including papillomavirus, polyomavirus, and simian virus 40, and have been detected in herpes simplex virus (HSV) capsids. In this study, we show that in mature HSV-1 virions, capsid proteins VP5, VP23, VP19C, UL17, and UL25 participate in covalent c...

journal_title：Journal of virology

authors： Szczepaniak R,Nellissery J,Jadwin JA,Makhov AM,Kosinski A,Conway JF,Weller SK

更新日期：2011-09-01 00:00:00

abstract：:Hepatitis delta virus (HDV) replicates its genome in the nucleus of an infected cell. However, an unsolved problem has been the identification in the cytoplasm of a putative mRNA for the synthesis of the only virus-coded protein, the delta antigen. We now report the characterization of an 800-base RNA that is cytoplas...

journal_title：Journal of virology

authors： Hsieh SY,Chao M,Coates L,Taylor J

更新日期：1990-07-01 00:00:00

abstract：:SER virus, a paramyxovirus that is closely related to simian virus 5 (SV5), is unusual in that it fails to induce syncytium formation. The SER virus F protein has an unusually long cytoplasmic tail (CT), and it was previously observed that truncations or specific mutations of this domain result in enhanced syncytium f...

journal_title：Journal of virology

authors： Seth S,Goodman AL,Compans RW

更新日期：2004-08-01 00:00:00

abstract：:A variant form of splicing of RNA crossing the Epstein-Barr virus (EBV) BZLF1 gene was observed in the late productive cycle of EBV. This splice omits the middle exon of BZLF1 and joins the outer two exons of BZLF1 in frame, but the shortened form of BZLF1 protein (Z delta) could not be detected in natural EBV infecti...

journal_title：Journal of virology

authors： Lau R,Packham G,Farrell PJ

更新日期：1992-10-01 00:00:00

abstract：:To analyze the biological activities of the alphavirus glycoproteins, eight different monoclonal antibodies against the two glycoproteins of western equine encephalitis virus were isolated. Five of the eight monoclonal antibodies were shown to be specific for E1 and three for E2 protein by an enzyme-linked immunosorbe...

journal_title：Journal of virology

authors： Yamamoto K,Hashimoto K,Chiba J,Simizu B

更新日期：1985-09-01 00:00:00

abstract：:Hantaviruses are rodent-borne agents that cause hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome in humans. The nucleocapsid protein (N) is relatively conserved among hantaviruses and highly immunogenic in both laboratory animals and humans, and it has been shown to induce efficient protective im...

journal_title：Journal of virology

authors： de Carvalho Nicacio C,Gonzalez Della Valle M,Padula P,Björling E,Plyusnin A,Lundkvist A

更新日期：2002-07-01 00:00:00

abstract：:The adenovirus type 5 mutant dl1520 was engineered previously to be completely defective for E1B-55K functions. Recently, this mutant (also known as ONYX-015) has been suggested to replicate preferentially in p53(-) and some p53(+) tumor cell lines but to be attenuated in primary cultured cells (C. Heise, A. Sampson-J...

journal_title：Journal of virology

authors： Harada JN,Berk AJ

更新日期：1999-07-01 00:00:00

abstract：:We have used immunofluorescence in parallel with transmission and scanning electron microscopy to characterize the unusual cytoplasmic and nucleolar accumulation of Simian virus 40 (SV40) virion protein (C antigen) at restrictive temperatures (39 to 41 C) in monkey cells infected with a temperature-sensitive mutant of...

journal_title：Journal of virology

authors： Widmer C,Robb JA

更新日期：1974-12-01 00:00:00

abstract：:Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells. Th1 polarization of Tfh cells is an important process shaping the success of Tfh-GC B cell interactions by influencing costimulatory and cytokine-dependent T...

journal_title：Journal of virology

authors： Verma A,Schmidt BA,Elizaldi SR,Nguyen NK,Walter KA,Beck Z,Trinh HV,Dinasarapu AR,Lakshmanappa YS,Rane NN,Matyas GR,Rao M,Shen X,Tomaras GD,LaBranche CC,Reimann KA,Foehl DH,Gach JS,Forthal DN,Kozlowski PA,Amara RR

更新日期：2020-02-28 00:00:00