Etiologies of the sicca syndrome: primary systemic amyloidosis and others.


BACKGROUND:The sicca syndrome has been defined as the occurrence of xerostomia and xerophthalmia. Sjögren's syndrome is the most common cause of the sicca syndrome; however, these two syndromes are not synonymous and there are many potential etiologies of the sicca syndrome. A less known cause of sicca syndrome is amyloidosis that to date has only been reported in the nondermatology literature. OBSERVATIONS:A 79-year-old man with known amyloidosis presented with persistent xerostomia. He had the classic cutaneous findings of periorbital and "pinch" purpura. A labial biopsy showed diffuse deposition of amorphous eosinophilic material surrounding salivary acini. Apple-green birefringence was noted with Congo red staining and the diagnosis was made of amyloidosis in the minor salivary glands causing xerostomia. CONCLUSIONS:The sicca syndrome can be caused by systemic amyloidosis. Because this fact is not in the dermatologic literature, many dermatologists are not aware of this uncommon presentation. The knowledge of the many causes of the sicca syndrome and an understanding of the differences between this and Sjögren's syndromes are important for any dermatologist.


Int J Dermatol


Richey TK,Bennion SD




Has Abstract


1996-08-01 00:00:00












  • Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

    abstract:BACKGROUND:Pityriasis lichenoides (PL) is a self-limiting papulosquamous disease that may persist for years and is associated with a high relapse rate. To date, few comparative studies have investigated the efficacy of narrowband ultraviolet B (NB-UVB) phototherapy and other therapies in the treatment of PL. OBJECTIVE...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Park JM,Jwa SW,Song M,Kim HS,Chin HW,Ko HC,Kim MB,Kim BS

    更新日期:2013-08-01 00:00:00

  • Characterization of circulating lymphocytes by monoclonal antibodies in childhood and adult leprosy.

    abstract::Peripheral blood lymphocyte assays using monoclonal antibodies were done in 66 patients with leprosy, consisting of 25 children and 41 adults. The results were statistically analyzed for correlations, if any, among the different age groups and matched controls. The results, however, failed to show any significant corr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sehgal VN,Chaudhry A,Sharma VK,Gupta CK

    更新日期:1991-11-01 00:00:00

  • Tinea pedis in Korean children.

    abstract:BACKGROUND:Tinea pedis is an infrequent disease in children before the age of puberty. There are few epidemiologic and clinical data regarding cases of tinea pedis observed in children. Materials and methods We prospectively collected all cases of tinea pedis in children diagnosed during the years 1995-1997. Only those...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Jang KA,Chi DH,Choi JH,Sung KJ,Moon KC,Koh JK

    更新日期:2000-01-01 00:00:00

  • Perforating granuloma annulare.

    abstract::With more than 3 years' follow-up, dramatic clinical transfiguration of granuloma annulare was observed in a 59-year-old man with perforating granuloma annulare. The eruption was at first localized, then became generalized, developed perforations, and subsided in parallel with the improvement of associated diabetes me...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Shimizu H,Harada T,Baba E,Kuramochi M

    更新日期:1985-11-01 00:00:00

  • Onychomycosis and AIDS. Clinical and laboratory findings in 62 patients.

    abstract::The results of a study on onychomycosis in AIDS related complex and AIDS patients presenting for dermatology consultation at an infectious diseases department are reported. The clinical results showed that most patients presented a proximal white superficial onychomycosis. The association with a clinical interdigital ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Dompmartin D,Dompmartin A,Deluol AM,Grosshans E,Coulaud JP

    更新日期:1990-06-01 00:00:00

  • Photodamaging effects of porphyrins and chitosan on primary human keratinocytes and carcinoma cell cultures.

    abstract:BACKGROUND:Photodynamic therapy (PDT) is a non-surgical method for treating non-melanoma skin cancer and precancerous lesions which involves the activation of a photosensitizer by visible light to produce activated oxygen species within target cells, resulting in the destruction of the latter. The present study evaluat...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Susan M,Baldea I,Senila S,Macovei V,Dreve S,Ion RM,Cosgarea R

    更新日期:2011-03-01 00:00:00

  • Lepromatous and tuberculoid leprosy: clinical presentation and cytokine responses.

    abstract:OBJECTIVE:This study analyzes the major clinical characteristics of patients with active leprosy in relation to the in vitro immune response to the T-lymphocyte activator anti-CD3. METHODS:Thirty-eight patients with an established diagnosis of leprosy were classified according to the Ridley and Jopling table. Peripher...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ochoa MT,Valderrama L,Ochoa A,Zea A,Escobar CE,Moreno LH,Falabella R

    更新日期:1996-11-01 00:00:00

  • Mycetoma.

    abstract::We have reviewed the outstanding facts about mycetoma, including the history, first reports in India, the different causal agents according to their geographic distribution, mycologic characteristics, pathology, microbiology, behavior, evolution, immunology, experimental inoculations, associated bacterial complication...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Magana M

    更新日期:1984-05-01 00:00:00

  • Immediate nonallergic psychotic reaction to intramuscular procaine penicillin.

    abstract:BACKGROUND:Though little known by medical personnel, an immediate nonallergic psychotic reaction to intramuscular procaine penicillin has been reported occasionally from many countries since 1951. MATERIALS AND METHODS:A case report describes a patient whose violent behavior, provoked by this reaction, resulted in leg...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Einterz EM,Einterz RM

    更新日期:1995-09-01 00:00:00

  • IgA dermatosis in an adult Chinese population. A 10-year study of linear IgA and dermatitis herpetiformis in Singapore.

    abstract::During a 10-year period (1976-1985), eight Chinese patients from a population of 2.5 million fulfilled the criteria for dermatitis herpetiformis and linear IgA bullous dermatosis (LABD). These rare diseases among Asians presented during the third decade of life with homogenous linear IgA deposits along the dermoepider...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ratnam KV

    更新日期:1988-01-01 00:00:00

  • Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway.

    abstract:BACKGROUND:Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen. Oxymatrine (OMT) is an alkaloid extracted from the Chinese herb Sophora japonica with capacities of anti-fibrosis. OBJECTIVE:To evaluate the effects of OMT on collagen production and to explo...

    journal_title:International journal of dermatology

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    authors: Fan DL,Zhao WJ,Wang YX,Han SY,Guo S

    更新日期:2012-04-01 00:00:00

  • The course and prognosis of pemphigus. A review of 115 patients.

    abstract::A survey of 115 pemphigus patients who have been followed for 4-24 years was carried out in an attempt to analyze the possible factors influencing the course and prognosis of the disease. At the time of the study, 45 patients were in complete remission, 45 still had lesions, and 25 had died. In 12 cases, the death occ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Seidenbaum M,David M,Sandbank M

    更新日期:1988-10-01 00:00:00

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    abstract:BACKGROUND:Epoxy resin compounds (ERC) include a large number of sensitizing chemicals such as epoxy resins (ER), hardeners (curing agents), and reactive diluents. Allergic contact dermatitis (ACD) caused by ERCS is often occupational. MATERIALS AND METHODS:We report a patient, sensitized to a hardener of a two-compon...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kanerva L,Estlander T,Jolanki R

    更新日期:1996-12-01 00:00:00

  • Treatment options in melanoma in situ: topical and radiation therapy, excision and Mohs surgery.

    abstract:BACKGROUND:The treatment of melanoma in situ (MIS), particularly the lentigo maligna (LM) subtype, has been a controversial subject in the literature for over a decade. Surgical excision with 5 mm margins is the standard of care in the USA, while several variations of Mohs surgery are frequently used to treat clinicall...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Erickson C,Miller SJ

    更新日期:2010-05-01 00:00:00

  • Mycosis fungoides with oral involvement.

    abstract::Oral mucous membrane involvement occurs uncommonly in mycosis fungoides and reports of it are scarce. We present two patients with severe involvement of the oral mucous membranes. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vicente A,Martí RM,Martín E,Estrach T,Herrero C,Mascaró JM

    更新日期:1991-12-01 00:00:00

  • Serum angiopoietin-2 level as a novel biomarker in atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease. Angiopoietin is an intrinsic mediator induced by T helper 2 cytokines and has been reported it to play a critical role in the pathogenesis of AD. OBJECTIVES:To determine the relationship between circulating angiopoietin-2 (Ang-2) in AD...

    journal_title:International journal of dermatology

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    更新日期:2019-11-04 00:00:00

  • Psoriasis and pregnancy: hormone and immune system interaction.

    abstract:BACKGROUND:Various hormonal states are known to be associated with the waxing and waning of psoriasis. Patients with psoriasis commonly experience changes in their cutaneous disease during pregnancy or post partum. OBJECTIVE:We evaluated 100 women with psoriasis by questionnaire and interview. The women had been seen ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Boyd AS,Morris LF,Phillips CM,Menter MA

    更新日期:1996-03-01 00:00:00

  • Tricoadenoma of Nikolowski.

    abstract::The patient, aged 50 years, with no relevant clinical history, complained of a symptomless, soft tumor of the right buttock that had been present for many years. On examination, it was found to be pediculate, oval, somewhat erythematous, firm on palpation, and with a central keratin plug. The greatest diameter of the ...

    journal_title:International journal of dermatology

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    authors: Bañuls J,Silvestre JF,Sevila A,Morell A,Betlloch I,Botella R

    更新日期:1995-10-01 00:00:00

  • Treatment of histoid leprosy: a lack of consensus.

    abstract::Histoid leprosy is a rare variant of leprosy with a unique clinical presentation and bacilli rich histology. These patients are large reservoirs for disease and vectors for spread, making prompt diagnosis and treatment crucial. To date, no consensus on treatment and duration exists. This paper aims to investigate the ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Bartos G,Sheuring R,Combs A,Rivlin D

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  • Post-kala-azar dermal leishmaniasis in Nepal.

    abstract:BACKGROUND:Post-kala-azar dermal leishmaniasis (PKDL) manifests as a skin eruption after healing of visceral leishmaniasis (VL), either spontaneously or as a result of treatment. This study was undertaken to describe the demographic, clinical, and histopathologic features of PKDL in Nepal. METHODS:Demographic, clinica...

    journal_title:International journal of dermatology

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    authors: Garg VK,Agrawal S,Rani S,Joshi A,Agarwalla A,Das ML,Koirala S

    更新日期:2001-03-01 00:00:00

  • Paracetamol induced Stevens-Johnson syndrome--toxic epidermal necrolysis overlap syndrome.

    abstract:BACKGROUND:Though any drug can be a potential cause of such hypersensitivity reactions, paracetamol, an over-the-counter drug used extensively as an analgesic and antipyretic agent, is considered to be relatively safe, with hepatotoxicity as a major adverse effect only in large doses. MATERIALS AND METHODS:We report a...

    journal_title:International journal of dermatology

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    authors: Biswal S,Sahoo SS

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  • Chagas' disease reactivation with skin symptoms in a patient with kidney transplant.

    abstract::Immunodepressed patients in the intermediate phase of Chagas' disease may undergo reactivation of the disease together with atypical symptoms. The case of an immunodepressed kidney transplant patient with reactivation of Chagas' disease with skin symptoms is reported. A 65-year-old man presented with infiltrated eryth...

    journal_title:International journal of dermatology

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    authors: Gallerano V,Consigli J,Pereyra S,Gómez Zanni S,Danielo C,Gallerano RH,Guidi A

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  • Oral lichen planus and HCV infection: a clinical evaluation of 263 cases.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection induces variable dermatologic manifestations. Our purpose was to determine whether there is an association between HCV infection and oral lichen planus (OLP). METHODS:Antibodies to HCV were determined in patients with OLP (263 patients; 156 women and 107 men, with a mean ag...

    journal_title:International journal of dermatology

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    authors: Mignogna MD,Lo Muzio L,Favia G,Mignogna RE,Carbone R,Bucci E

    更新日期:1998-08-01 00:00:00

  • Role of linoleic acid in arsenical palmar keratosis.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ahmed TS,Misbahuddin M

    更新日期:2016-03-01 00:00:00

  • The insecticidal activity of four medicinal plants against the blowfly Lucilia sericata (Diptera: Calliphoridae).

    abstract:BACKGROUND:The larvae of Lucilia sericata induce myiasis and transmit mycobacterial infections to humans and animals. Consequently, the blowfly should be controlled for human welfare and economic reasons. METHODS:The insecticidal effect of fenugreek (Trigonella foenum-graecum), celery (Apium graveolens), radish (Rapha...

    journal_title:International journal of dermatology

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    authors: Khater HF,Khater DF

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Faillace C,Duarte GV,Cunha RS,de Carvalho JF

    更新日期:2013-02-01 00:00:00

  • Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Terras S,Gambichler T,Moritz RK,Altmeyer P,Lambert J

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    abstract::Light and electron microscopic studies in a case of nasal glioma revealed a tumor composed nearly entirely of astrocytes. No ganglion cells or neurons were present and the mass was not surrounded by a capsule reminiscent for meningeal tissue. The vasculature resembled dermal patterns rather than typical central nervou...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Gebhart W,Hohlbrugger H,Lassmann H,Ramadan W

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  • Myiasis owing to Dermatobia hominis in a HIV-infected subject: Treatment by topical ivermectin.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Clyti E,Nacher M,Merrien L,El Guedj M,Roussel M,Sainte-Marie D,Couppié P

    更新日期:2007-01-01 00:00:00

  • Sclerosing dermatofibrosarcoma protuberans (DFSP): an unusual variant with focus on the histopathologic differential diagnosis.

    abstract::A 59-year-old man presented with a 10-cm x 8-cm tumoral plaque with a superficial nodule in the interscapular region of the back (Fig. 1). The lesion had been growing for 25 years. As a cystic lesion was suspected, the superficial nodule was biopsied. The histopathologic diagnosis was low-grade sarcoma with sclerosis....

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sabater-Marco V,Pérez-Vallés A,Berzal-Cantalejo F,Rodriguez-Serna M,Martinez-Diaz F,Martorell-Cebollada M

    更新日期:2006-01-01 00:00:00