Abstract:
BACKGROUND:The early diagnosis and therapy of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency can prevent adrenal crises and erroneous gender assignment in affected newborns. To achieve this goal neonatal mass-screening programs have been developed, measuring blood 17 alpha-hydroxyprogesterone (17OHP). In Chile there is no experience with this type of screening. AIM:To develop a method for measuring 17OHP in filter paper blood specimens. To obtain reference ranges and determine neonatal 17OHP threshold levels according to gestational age and birth weight. To analyze factors affecting the cost-efficiency ratio and suggest recommendations for the organization of a neonatal screening program for CAH in Chile. MATERIAL AND METHODS:Nine hundred twenty two newborns were studied. 17OHP was measured using double antibody radioimmunoassay in filter paper blood samples obtained 48 h after birth. Reference ranges were determined according to gestational age and birth weight and a cutoff point of 25 ng/ml was established. RESULTS:Seventeen newborns had 17OHP over the cutoff value. They were assessed by a pediatric endocrinologist and in none of them, CAH was confirmed. Therefore the false positive rate of the determination was 1.8%. Among these newborns with elevated 17OHP, 66% had a birth weight below 1.5 kg and 5.8%, a birth weight between 1.5 and 2.5 kg. The cost per reported result was US $ 1. Timing of the recall was between the 3 and 10 days of life. No newborn missed the follow-up. DISCUSSION:To increase the cost-efficiency ratio of an eventual neonatal screening program, newborns with birth weights below 1.5 kg should be excluded and cutoff points should be defined according to birth weight (Rev Méd Chile 2000; 128: 1113-18).
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Cattani A,Reyes ML,Azócar M,Soto J,Romeo E,Valdivia L,Poggi H,Foradori Asubject
Has Abstractpub_date
2000-10-01 00:00:00pages
1113-8issue
10eissn
0034-9887issn
0717-6163journal_volume
128pub_type
杂志文章abstract::Bacteria have developed sophisticated and successful genetic mechanisms to evade the action of antimicrobials. Bacterial multiresistance has caused serious problems in the treatment of nosocomial infections. Integrons and gene cassettes are considered the main genetic elements in the evolution of plasmids and transpos...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872004000500013
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Despite the low frequency of thyroid nodules (TN) in children, one of every four is malignant. Fine-needle aspiration cytology (FNAC) has a high accuracy detecting thyroid cancer. AIM:To evaluate the performance of FNAC in TN in Chilean children to detect thyroid cancer. PATIENTS AND METHODS:The pathologic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000300007
更新日期:2014-03-01 00:00:00
abstract::An analysis of the interaction of evolutionary factors such as migration, mutation, selection random drift, and consanguinity upon the genome of Easter islanders is attempted. As many primitive populations, the Easter islanders genome has at least 2/3 of genetic loci in an isogenic state. The HLA system is reduced; ot...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-06-01 00:00:00
abstract::During colonial times the Royal University of San Felipe was founded in 1738. The first plan for medical studies was outlined in 1779. During the Independence, the National Institute created in 1813 took over higher education. The first Course of Medicine was dictated there in 1833. The University of San Felipe was re...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::We report a 11 years old male diagnosed as a X-linked hyper-IgM syndrome that presented with recurrent infections and sclerosing cholangitis and later developed a gallbladder cancer. Immunological evaluation showed decreased levels of serum IgG and IgA with elevated levels of IgM. Study of CD40 ligand expression on mi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::The incidence of hepatitis, mumps, poliomyelitis, scarlet fever, pertussis and measles from 1954 to 1984 was studied from the annual records of infectious diseases. Fluctuations were evaluated by Fourier analysis. Periodic recurrency was detected for poliomyelitis, scarlet fever, pertussis and measles and was likely f...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:CEA is widely used in the follow up of patients with colorectal carcinoma. AIM:To study the value of preoperative CEA as an independent prognostic factor in colorectal carcinoma. PATIENTS AND METHODS:Analysis of 373 operated patients (204 females, age range 21-92 years) with colorectal carcinoma and a mean...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000600005
更新日期:2004-06-01 00:00:00
abstract::Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral purpuric rash in the limbs with severe malaise. Specific IgM antibodies in ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008000500011
更新日期:2008-05-01 00:00:00
abstract::Platelet Rich Plasma (PRP) is used in musculoskeletal lesion surgery, including muscle, bone, tendons and ligaments. PRP might accelerate the healing process and the integration of the graft, allowing an earlier return to sports activities of patients. PRP is obtained from autologous blood, which is centrifuged, obtai...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872013001000011
更新日期:2013-10-01 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequels. HSV-1 infects limbic system ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872011000600013
更新日期:2011-06-01 00:00:00
abstract::A 54 years old female patient with a mitral valve prolapse and a rheumatoid arthritis treated with steroids was admitted with dyspnea and hypotension, that started 30 min after taking a pill containing enapril and hydrochlorothiazide. Hemodynamic monitoring with a Swan-Ganz catheter showed a pulmonary capillary pressu...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::The results of a prospective protocol for the management of patients with gastric cancer applied from May 1988 to June 1991 are reported. 123 patients were operated on and a resection performed in 55%. Only 14 patients had incipient tumor and 44 had "curative" surgery. There was a preponderance of non differentiated t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::The decrease in mortality in critical patient units led to an increase in intensive care unit acquired weakness (ICUAW), which significantly affects the functional performance and quality of life of patients. There are several scales that measure functionality in critical patients. The aim of this systematic review is...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872017000901137
更新日期:2017-09-01 00:00:00
abstract::Nucleolar organizer regions may be observed by colloidal silver stains. A considerable increase in the number of regions may be observed in tumors and other pathologic processes as an index of cellular proliferation. Among 20 studies in patients with gastric carcinoma we found a significantly greater number of nucleol...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::We report a 52 year old man with a pancreatic pseudocyst, that was admitted with severe abdominal pain, severe vomiting, fever and malaise. The clinical picture was considered secondary to a pseudocyst infection and the patient was operated, draining the infected cyst performing a necrosis surgery and pancreatojejunos...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:There is a very strong documented correlation between the appearance of cancer cells in blood and occurrence of metastasis in gastrointestinal cancer. AIM:To determine MUC1, CK19, CK20 and CEA mRNA expression in bone marrow of patients with gallbladder cancer and evaluate its clinical significance. MATERIA...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Type 1 diabetes mellitus (DM1) is a disease of increasing incidence among children. The time elapsed between the beginning of symptoms and the diagnosis of the disease is, in most cases, very extended. AIM:To report the clinical picture at onset and laboratory features of children with DM1. MATERIAL AND ME...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006001200007
更新日期:2006-12-01 00:00:00
abstract::Laugier-Hunziker syndrome is a rare benign idiopathic condition characterized by acquired macular pigmentation of lips and buccal mucosa, often accompanied with melanonychia. The main concern with this condition is to rule out other differential diagnosis with systemic repercussions and similar hyperpigmentation patte...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016000500017
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Adolescent alcohol and drug consumption are important public health problems in the Chilean young population. AIM:The purpose of this study was to examine the potential ofa data mining approach in scaffolding policy making, using the particular case of differential risks of harmful alcohol consumption in ad...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000500013
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Self-efficacy refers to people's expectations about personal resources available for goal achievement. Higher self-efficacy expectations are correlated with higher academic performance. AIM:To analyze the psychometric properties of the Academic Behavior Self-Efficacy Scale (ABSES) and to describe Self-effic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000700914
更新日期:2019-07-01 00:00:00
abstract::Due to the social and economical changes in the Chilean university and health systems in the last decades, the traditional financing model of the Faculty of Medicine and postgraduate training programs became obsolete. The progressive reduction of the fiscal budget has forced the search of alternate financing sources. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Measuring the carbon footprint (CF) makes it possible to estimate the contribution of clinical activity to global warming. AIM:To measure the emitter components of CO2 equivalents (CO2e) at the Hospital Base, Puerto Montt (HBPM). MATERIAL AND METHODS:Descriptive study with data collected retrospectively be...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018001201384
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Glycine inhibits the formation of advanced glycation end products that may cause central and peripheral neuronal damage, affecting also the auditory nerve. AIM:To evaluate the effect of glycine on auditory nerve conduction and hearing level among patients with type 2 diabetes mellitus and auditory neuropath...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010001100006
更新日期:2010-10-01 00:00:00
abstract::Starting of from the notion that medicine presents a plurality of aims, it is proposed that it should be conceived as a "science of actions" rather than as a "science of objects". Health is not a neutral "object" that could be unambiguously defined and approached from any vantage point solely with the standards of a d...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Pharmacological treatment improves survival in patients with heart failure with reduced ejection fraction. The use of sacubutril/valsartan and ivabradine has been recently approved and incorporated in the latest guidelines. AIM:To identify candidates eligible for these therapies among patients treated in a ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000300330
更新日期:2019-03-01 00:00:00
abstract::Using mapping techniques, 32 consecutive gallbladder carcinomas diagnosed in our department were studied. The defined lesions were dysplasia, carcinoma in situ and superficial spreading carcinoma. A total of 2257 lesions were recorded from 1072 inclusions. All the defined lesions were present in about 10% of all secti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea syndrome (OSA) is an important cause of morbidity and mortality in adults. AIM:To evaluate the diagnostic value of clinical features and oximetric data to screen for obstructive sleep apnea before performing polysomnograpy or respiratory polygraphy. MATERIAL AND METHODS:We studied 3...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000800001
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults. AIM:To determine the immunogenicity and reactogenicity of a diphtheria-tetanus-acellular pertussis (dTpa) vaccine with reduced antigen content. MATERIAL AND METHODS:A single dose of the dTpa vaccin...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::We report a 52 years old male admitted for fever lasting one month, dry cough, headache and malaise. Initial laboratory work up showed an AST of 172 U/l, and ALT of 252 U/l, a GGT of 353 U/l and alkaline phosphatases of 952 U/l. An abdominal CAT scan disclosed a mild hepatosplenomegaly. A liver biopsy showed a granulo...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::Environmental factors may influence the development of Inflammatory Bowel Disease and modify its natural history. The objective of this review is to evaluate current evidence about environmental factors associated with the disease. A better knowledge about the pathogenesis of the disease can lead to better treatment s...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872019000200212
更新日期:2019-02-01 00:00:00