[Carcinoembryonic antigen (CEA) as an independent prognostic factor in colorectal carcinoma].

Abstract:

BACKGROUND:CEA is widely used in the follow up of patients with colorectal carcinoma. AIM:To study the value of preoperative CEA as an independent prognostic factor in colorectal carcinoma. PATIENTS AND METHODS:Analysis of 373 operated patients (204 females, age range 21-92 years) with colorectal carcinoma and a mean follow up of 53 months. The cutoff value for CEA was 5 ng/ml. Ninety four percent of patients had an excisable tumor, 79% had involvement of perirectal/pericolonic adipose tissue and 46% had lymph node involvement. Staging was done using Dukes-Turnbull and TNM classifications. RESULTS:CEA was normal in 61% of cases, over 5 ng/ml in 39% and over 15 ng/ml in 22%. There was a strong correlation between mean preoperative CEA and tumor stage, depth and lymph node involvement. During the follow up, 140 patients died, 57 with normal and 83 with elevated CEA. Cancer mortality in patients subjected to a curative excision of the tumor (Dukes A-C2/TNM I-III) was 9% for colonic tumors and 36% for rectal tumors (p < 0.001). There were no survival differences in patients with Dukes B/TNM II tumors according to preoperative CEA. Among Dukes C/TNM III tumors, survival difference was only significant for rectal tumors. A Cox model disclosed tumor stage, location and preoperative CEA as independent prognostic factors for survival. CONCLUSIONS:CEA is an independent prognostic factor for survival in colorectal carcinoma and high levels suggest an advanced disease.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Bannura G,Cumsille MA,Contreras J,Barrera A,Melo C,Soto D

doi

10.4067/s0034-98872004000600005

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

691-700

issue

6

eissn

0034-9887

issn

0717-6163

journal_volume

132

pub_type

杂志文章
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