Abstract:
:Herpes simplex virus type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequels. HSV-1 infects limbic system structures in the central nervous system (CNS), and has been suggested as an environmental risk factor for Alzheimer's disease. The possibility that HSV-1 reactivates in CNS neurons causing chronic progressive damage at cellular level and altering the neuronal functionality has not been thoroughly investigated. Currently it is ignored if recurrent reactivation of HSV-1 in asymptomatic patients involves some risk of progressive deterioration of the CNS functions caused, in example, by a neuroinflammatory response against the virus or by direct toxicity of the pathogen on neurons. Therefore, studies regarding the routes of dissemination of HSV-1 from the peripheral ganglions to the CNS, as well as the possible cellular and molecular mechanisms implied in generating neuronal damage during latent and productive infection, are of much relevance.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Martin C,Solís L,Concha MI,Otth Cdoi
/S0034-98872011000600013subject
Has Abstractpub_date
2011-06-01 00:00:00pages
779-86issue
6eissn
0034-9887issn
0717-6163pii
S0034-98872011000600013journal_volume
139pub_type
杂志文章,评审abstract::We evaluated pharmacokinetic parameters and bioavailability of 4 sustained release theophylline preparations. A crossover design was used in 12 healthy males aged 22 to 27 years old. Each individual received 250 mg iv followed by 250 mg orally of each preparation, and then 400 mg rapid acting aminophylline. A 7 day pe...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::The rapid advances in immunobiology, pharmacology and molecular biology have made successful renal transplantation the optimal therapeutic modality for adults and children, reaching a near--90% of patient-graft survival among the first years of transplant. But this knowledge also presents clinicians and scientists wit...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUNDS AND AIMS:Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total enteral nutrition in this situation. METHODS:After 48 hours of...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Quality has a central role in medical care. The satisfaction of the rights of people to medical care, presupposes good quality medical acts. The meaning of quality goes further than a good attention based on scientific evidence and with competent skills. It comprises patient-physician relationship where professional b...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::Recent reports have described a pathogenic role of nitric oxide in several respiratory disease. It is specially useful in the adult respiratory distress syndrome, where it acts as a selective vasodilator and improves gas exchange, decreasing pulmonary shunting. Although it has a proven bronchodilator effect, its thera...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Few trials have studied the prevalence of sexual dysfunction (SD) and related risk factors in postmenopausal women using the DSM-IV criteria. AIM:To evaluate the prevalence of SD in menopausal women and the impact of risk factors. PATIENTS AND METHODS:Five hundred thirty four healthy women, 40 to 64 years ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Evaluation of 24-hour collection accuracy is based on urinary creatinine excretion (UCr), usually using wide ranges indexed by weight. Equations that predict the expected UCr are also available. AIM:To generate an equation for estimating UCr in Chilean population and evaluate its performance in comparison t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872020000600734
更新日期:2020-06-01 00:00:00
abstract::Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the pers...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872009000500014
更新日期:2009-05-01 00:00:00
abstract::Three patients seen at the Medicine Department of Del Salvador Hospital between 1986 and 1990 are reported. All had a history of purulent or bloody nasal discharge and recurrent sinusitis, before the appearance of progressive and painful destructive phenomena that affected the rhino faucial region. The diagnosis was m...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::Environmental factors may influence the development of Inflammatory Bowel Disease and modify its natural history. The objective of this review is to evaluate current evidence about environmental factors associated with the disease. A better knowledge about the pathogenesis of the disease can lead to better treatment s...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872019000200212
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Aortic valve stenosis is the most prevalent valvulopathy in the elderly, but it is frequently undertreated. AIM:To assess early and long term results of valve replacement with bioprostheses in patients 70 years old or older with aortic stenosis. PATIENTS AND METHODS:A review of the database of the Cardiova...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000200002
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:the six minute walking distance test (6MWD) is widely used to evaluate exercise capacity in several diseases due to its simplicity and low cost. AIM:to establish reference values for 6MWD in healthy Chilean individuals. MATERIAL AND METHODS:we studied 175 healthy volunteers aged 20-80 years (98 women) with...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000900006
更新日期:2010-09-01 00:00:00
abstract::Heterozygous familial hypercholesterolemia affects one every 400 individuals, is caused by mutations in the LDL receptor gene and is associated with premature coronary artery disease. Nowadays, LDL cholesterol can be efficiently reduced with the new therapies to reduce blood lipids. We report a female patient who cons...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000200011
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Psychological problems are a frequent cause of consultation in primary care outpatient clinics. AIM:To report the results for Santiago de Chile of the World Health Organisation multicentric collaborative study on Psychological Symptoms in General Health Care. PATIENTS AND METHODS:The results of 1453 patien...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1998-04-01 00:00:00
abstract::Between January 1980 and December 1990, 16 patients with acute mitral insufficiency were operated on an emergency basis at our institution. They represented 1.8% of all mitral surgical cases. All of them were in acute pulmonary edema and 7 in cardiogenic shock. The etiology was ischemic in 6, degenerative in 4, infect...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::Echotomographic studies were performed in 163 patients with gastric cancer from 1984 to 1990. The technical aspects of the examination and the images obtained in different lesions are described. Emphasis is placed on local or diffuse wall infiltration, ulcerations, vegetations or stenotic lesions. Consideration of the...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. AIM:To investigate the association of TCF7L2 (rs7903146) genotype...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000800965
更新日期:2019-08-01 00:00:00
abstract::Aiming to correlate the alterations in evoked potentials with the initial clinical manifestations of multiple sclerosis, 29 patients with the disease were studied and 19 were followed for a lapse ranging from 1 to 11 years. Visual evoked potentials were studied in all the patients and 51% were abnormal. Auditory evoke...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Adverse reactions to intravascular contrast media are infrequent in radiological practice and rarely pose a life threatening risk. Contraindication to contrast injection should be evaluated and prophylactic measures taken, if available, in patients with risk factors for adverse reactions. Details of pathogenesis, freq...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1991-07-01 00:00:00
abstract::Approximately 15% of patients with Wolff Parkinson White's syndrome who undergo electrophysiologic study have more than one accessory pathway. We describe the electrophysiologic testing and findings in 2 patients with multiple pathways. Identification of these is highly relevant since successful surgical therapy depen...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract:AIM:To measure the impact of day care attendance on lower respiratory tract infections in children under two years old in two urban settings with different degrees of air pollution. SUBJECTS AND METHODS:A 26 week follow up, during fall and winter of 1991 and 1992, was performed to 98 children (48 attending day care an...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Gabriel Cano de Aponte was Governor of Chile since 1717 and until his death in 1733, being 68 years old. As a soldier, he was an experienced horse rider. The sequence of events that caused his death three months after an equestrian accident is unclear. A systematic clinical analysis of the latter is the main objective...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:/S0034-98872008000900020
更新日期:2008-09-01 00:00:00
abstract::Professor Raúl B. Etcheverry, M.D., was a founder of Chilean Hematology back in the 1940's and a practicing physician and teacher until an advanced age. Being a superb clinician, he was admired by his ability to unveil from the most common to the most difficult diagnosis of blood disorders and neoplasms by examining b...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:10.4067/S0034-98872014000300017
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Measuring the carbon footprint (CF) makes it possible to estimate the contribution of clinical activity to global warming. AIM:To measure the emitter components of CO2 equivalents (CO2e) at the Hospital Base, Puerto Montt (HBPM). MATERIAL AND METHODS:Descriptive study with data collected retrospectively be...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018001201384
更新日期:2018-12-01 00:00:00
abstract::Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chilean alcoholics. We ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Spontaneous hemoperitoneum secondary to intraabdominal variceal rupture, is an uncommon and highly lethal complication of cirrhosis. We report a case of a 68 years old male submitted because of abdominal pain and fainting. The clinical and laboratory work up concluded that the patient had cirrhosis and hemoperitoneum....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract::One of the most important topics mentioned by people from places affected by the February 27th, 2010 earthquake to the Presidential Delegation for the Reconstruction, was the urgent need of mental health care. Given the enormous individual and social burden of mental health sequelae after disasters, its treatment beco...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016000200014
更新日期:2016-02-01 00:00:00
abstract::Cyclic neutropenia is a rare disease in which blood neutrophils periodically decrease and almost disappear, ensuing acute infections of variable severity. We report a 37 years old female presenting with severe abdominal pain, fever and neutropenia. During a surgical abdominal exploration, an acute ileitis was found. D...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Using mapping techniques, 32 consecutive gallbladder carcinomas diagnosed in our department were studied. The defined lesions were dysplasia, carcinoma in situ and superficial spreading carcinoma. A total of 2257 lesions were recorded from 1072 inclusions. All the defined lesions were present in about 10% of all secti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Kikuchi and Fujimoto disease is a benign subacute necrotizing lymphadenitis, probably associated to a viral infection, that affects mostly young Asian women. We report a 19 years old women, with a vast familiar history of thyroid disease (three uncles with papillary thyroid carcinoma and one with a Hashimoto thyroidit...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00