[The bioavailability of 4 sustained-release theophylline preparations from the Chilean market].

Abstract:

:We evaluated pharmacokinetic parameters and bioavailability of 4 sustained release theophylline preparations. A crossover design was used in 12 healthy males aged 22 to 27 years old. Each individual received 250 mg iv followed by 250 mg orally of each preparation, and then 400 mg rapid acting aminophylline. A 7 day period was allowed between drug courses. HPLC was used to determine plasma levels of theophylline at regular intervals up to 48 hr following drug administration. Significant (p < 0.05) differences in pharmacokinetic parameters were found among preparations, 2 of them having larger integrals of plasma levels and one of them different times to peak plasma level and peak plasma concentration, compared to both remaining preparations.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Biagini L,Zamora P,Chávez H,Saavedra I

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

1241-6

issue

11

eissn

0034-9887

issn

0717-6163

journal_volume

118

pub_type

杂志文章
  • [Primary adrenal insufficiency due to autoimmune adrenalitis].

    abstract::We report a 10 years old boy, admitted with a history of asthenia, anorexia and weight loss of 4 kg. Initial laboratory work up showed metabolic acidosis and hyponatremia. The patient had no circadian rhythm of serum cortisol and an adrenal stimulation test confirmed the presence of adrenal insufficiency. Anti-adrenal...

    journal_title:Revista medica de Chile

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    doi:

    authors: Muzzo S,Izquierdo G,Verbeke S

    更新日期:2002-08-01 00:00:00

  • [Duffy blood group in malformed newborns and their mothers].

    abstract::The aim of this work is to analyze the distribution of Duffy blood group and the reproductive history of 148 malformed newborns and their mothers compared to 131 control pairs. The mother-child segregation of the system is analyzed using ITO matrixes. A higher frequency of heterozygote mothers for the system was found...

    journal_title:Revista medica de Chile

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    doi:

    authors: Cifuentes L,Nazer J,Armanet L,Ruiz G,Vargas J

    更新日期:1994-09-01 00:00:00

  • [Association between handgrip strength and functional performance in Chilean older people].

    abstract:BACKGROUND:Handgrip strength is an important predictor of functional performance among older adults. AIM:To measure handgrip strength in older adults and relate its values to their clinical functional assessment. MATERIAL AND METHODS:Handgrip strength was measured in 1047 older adults living in the community and aged...

    journal_title:Revista medica de Chile

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    doi:10.4067/S0034-98872016000500007

    authors: Mancilla S E,Ramos F S,Morales B P

    更新日期:2016-05-01 00:00:00

  • [Sézary syndrome treated with extracorporeal photopheresis: Report of one case].

    abstract::Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management of SS depends on its stage, patient com...

    journal_title:Revista medica de Chile

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    doi:10.4067/S0034-98872015001100011

    authors: Molgó M,Jaque A,Vial V,Ocqueteau M,Pereira J,Chang M,González S

    更新日期:2015-11-01 00:00:00

  • [Focal hepatic lesions observed by echotomography with special reference to hydatidosis].

    abstract::This article reports the results of 1080 ultrasonographic examinations of the liver in a clinic of the Ninth Region of Chile, using a SSD 620 Aloka equipment. In 61 examinations (5.6%) a focal liver lesion was found. Of these, 9 (14.7% of lesions) appeared as malignant (6 metastasis and 3 hepatomas) and 52 (85.3% of l...

    journal_title:Revista medica de Chile

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    doi:

    authors: Calderón C

    更新日期:1994-03-01 00:00:00

  • [Clinical features of patients with Basedow Graves disease seen at a university hospital].

    abstract:BACKGROUND:Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. AIM:To describe the clinical features of patients with BGD seen at a university hospital. MATERIAL AND METHODS:Revie...

    journal_title:Revista medica de Chile

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    doi:10.4067/S0034-98872017000400003

    authors: Lanas A,Díaz P,Eugenin D,González F,Cid P,Cordero F,Araya V,Liberman C,Barberan M,Gac P,Saldías N,Pineda P

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  • [Application of a system of serological surveillance of Chagas disease in a region of high chagasic endemia. I. Prevalence of Trypanosoma cruzi infection in Salamanca].

    abstract::A serologic study for prevalence of Chagas infection was performed in Salamanca, Northern Chile. Indirect immunofluorescence and indirect hemagglutination reactions were used in samples from 1529 females and 698 males representing 10% of the population. A total of 499 positive results were obtained. The incidence of i...

    journal_title:Revista medica de Chile

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    doi:

    authors: Lorca M,Reyes V,Muñoz P,Tassara R,Canales M,Mercado R,Atías A

    更新日期:1991-04-01 00:00:00

  • [Hodgkin lymphoma in Chile: experience of the national adult cancer program].

    abstract:BACKGROUND:Hodgkin lymphoma is a highly curable disease. AIM:To evaluate the clinical characteristics and the treatment results of Hodgkin lymphoma patients of the National Cancer Program in Chile. PATIENTS AND METHODS:Prospective assessment of 682 patients treated in 18 adult cancer centers. Progression free surviva...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,多中心研究

    doi:10.4067/s0034-98872007000300009

    authors: Cabrera ME,García H,Lois V,León A,Peña K,Rossle A,Cerda B,Rojas H,Meneses P,Merino C,Aspillaga A,Vittini de C,Oliva J,Hales C,Rosas J,Programa Nacional de Cáncer del Adulto, Ministerio de Salud.

    更新日期:2007-03-01 00:00:00

  • [Frequency of oral squamous cell carcinoma and oral epithelial dysplasia in oral and oropharyngeal mucosa in Chile].

    abstract:BACKGROUND:Oral cancer in Chile corresponds approximately to 1.6% of all cancer cases. There are few studies about oral epithelial dysplasia and oral squamous cell carcinoma in the Chilean population. AIM:To determine the frequency of hyperkeratosis, mild, moderate and severe oral epithelial dysplasia, in situ carcino...

    journal_title:Revista medica de Chile

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    doi:10.4067/S0034-98872016000200004

    authors: Martínez C,Hernández M,Martínez B,Adorno D

    更新日期:2016-02-01 00:00:00

  • [An update on the pathogenesis of celiac disease].

    abstract::Celiac disease (CD), with a 1% worldwide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, which codify for histocompatibility molecules HLA DQ-2/DQ-8. From the anatomical point of view, CD is characterized by intestinal villous atrophy, crypt hyperplasia,...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:/S0034-98872009001200012

    authors: Herrera MJ,Hermoso MA,Quera R

    更新日期:2009-12-01 00:00:00

  • [Esophageal manometry in patients with non cardiac chest pain].

    abstract:BACKGROUND:Non cardiac chest pain can be caused by esophageal problems such as gastroesophageal reflux or smooth muscle motor disorders. AIM:To perform esophageal manometry in patients with non cardiac chest pain. MATERIAL AND METHODS:One hundred patients with chest pain in whom coronary problems were discarded, were...

    journal_title:Revista medica de Chile

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    doi:10.4067/s0034-98872006000300004

    authors: Rencoret G,Csendes A,Henríquez A

    更新日期:2006-03-01 00:00:00

  • [Prevalence of calorie protein malnutrition among patients in chronic hemodialysis].

    abstract:BACKGROUND:Malnutrition has been strongly associated with morbidity and mortality in hemodialysis patients. In the other hand, dialysis allows a nutritional improvement in patients with more than 12 months in dialysis. AIM:To study the prevalence of malnutrition among patients in hemodialysis. PATIENTS AND METHODS:We...

    journal_title:Revista medica de Chile

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    doi:

    authors: Huidobro A,Velasco N,Rojas T

    更新日期:2001-05-01 00:00:00

  • [Rapid aspirin desensitization in patients with a history of aspirin hypersensitivity requiring coronary angioplasty. Report of four cases].

    abstract::Aspirin use is necessary after a coronary angioplasty. It should not be used in patients with a history of hypersensitivity. However, rapid desensitization protocols have been reported to allow its use in such patients. One of these protocols consists in the administration of progressive doses of aspirin, from 1 to 10...

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    authors: Veas P N,Martínez G,Jalil M J,Martínez S A,Castro G P

    更新日期:2013-02-01 00:00:00

  • [The relevance of environmental health and the scope of pediatric environmental health specialty units].

    abstract::In the last decades there has been an important decrease in infant mobidity and mortality, but these achievements are not equally distributed across the whole population. Children are one of the most susceptible groups due to their unique vulnerabilities to environmental factors. Unhealthy environments, indoor polluti...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000100016

    authors: París M E,Bettini M,Molina H,Mieres JJ,Bravo V,Ríos JC

    更新日期:2009-01-01 00:00:00

  • [Spontaneous closure of a residual fistula after surgical closure of a traumatic aorto-right ventricular fístula. Report of one case].

    abstract::We report a 16-year-old boy, who suffered a right vent ride penetrating injury caused by a sharp blade that evolved to cardiac tampon. He underwent surgery and was discharged four days later. Thirteen days later, a cardiac murmur was found. An echocardiography showed an aorta-right ventricular fistula. Surgical closur...

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    doi:/S0034-98872010000200010

    authors: González R,Santander C,Seguel E,Stockins A,Alvarez R,Cárdenas P,Campos R,Alarcón E

    更新日期:2010-02-01 00:00:00

  • [Health-related quality of life in Chilean patients with chronic obstructive pulmonary disease].

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) has a relevant impact on health-related quality of life (HRQoL). Short Form 6 dimensions (SF-6D) quality of life tool allows researchers to calculate preference-based utilities using data from SF-12 or SF-36 questionnaires. AIM:To provide normative values of SF-6...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872017000200001

    authors: Collado-Mateo D,Adsuar JC,Olivares PR,García-Gordillo MÁ

    更新日期:2017-02-01 00:00:00

  • [A national online survey applied to patients with celiac disease in Chile].

    abstract:BACKGROUND:Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Its prevalence in Europe and the USA is 0.5 to 1%. AIM:To analyze epidemiological aspects and degree of compliance with gluten-free diet (GFD) among Chilean individuals with CD....

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872011000700003

    authors: Espino A,Castillo L C,Guiraldes E,Santibáñez H,Miquel JF

    更新日期:2011-07-01 00:00:00

  • [Possible perinatal determinants of morbidity in adult age].

    abstract::Recently, several groups have studied the influence of possible noxious elements present in the intrauterine environment which may favor the development of several diseases in the adult. There is evidence of an increased prevalence of some disorders in special risk groups of fetuses. In the small for gestational age p...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Aros S,Cassorla F

    更新日期:2001-03-01 00:00:00

  • [Immune response against modified low-density lipoproteins in patients with non-insulin-dependent diabetes mellitus].

    abstract:BACKGROUND:Diabetes mellitus is a risk factor for atherosclerosis. Low density lipoproteins are considered a key factor in the formation of atheroma and the immune system has an important contribution to this process. AIM:To quantify the immune response against modified low density lipoproteins in patients with non in...

    journal_title:Revista medica de Chile

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    doi:

    authors: González M,Rojas N,Durán D,Schade A,Campos R,Milos C

    更新日期:1997-08-01 00:00:00

  • [Recent case law about the right to die].

    abstract::This paper reviews the sentences dictated between 1993 and 2002 by the Supreme Courts of Canada and the Unites States, the House of Lords and Supreme Court of the United Kingdom and the European Human Rights Court, about the validity of the legal prohibition of assistance for suicide. These sentences constituted a jud...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872016000400009

    authors: Bascuñán R A

    更新日期:2016-04-01 00:00:00

  • [Clinical picture at the onset of type 1 diabetes mellitus in children].

    abstract:BACKGROUND:Type 1 diabetes mellitus (DM1) is a disease of increasing incidence among children. The time elapsed between the beginning of symptoms and the diagnosis of the disease is, in most cases, very extended. AIM:To report the clinical picture at onset and laboratory features of children with DM1. MATERIAL AND ME...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872006001200007

    authors: Hodgson B MI,Ossa A JC,Velasco F N,Urrejola N P,Arteaga L I A

    更新日期:2006-12-01 00:00:00

  • [Chilean hospitals: availability and productivity of the public and private sectors].

    abstract::Hospital bed availability, trends in number of beds, productivity and administrative aspects in the public and private hospital sectors are analyzed. At present, there are 3.3 beds per 1000 population in Chile. This represents a decrease from previous figures, in spite of increasing demands derived from population agi...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Medina E,Kaempffer AM

    更新日期:1992-03-01 00:00:00

  • [Aneurysmal bone cyst of the maxilla. Report of one case].

    abstract::Aneurysmal bone cysts are benign fibro osseous lesions, rarely present in maxillary region. We report the CT and morphological findings of aneurysmal bone cyst of the maxilla in a 15 years old female. The patient was subjected to a maxillectomy, preserving the orbit floor. The postoperative evolution has been uneventf...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005001100012

    authors: Guzmán G P,Baeza O A,Araya O J,Roa S J,Brevis O L,Torres L P

    更新日期:2005-11-01 00:00:00

  • [Placement of a biventricular resynchronization device in a patient with a persistent left superior vena cava: report of one case].

    abstract::Persistent left superior vena cava is the most common venous congenital malformation and is usually asymptomatic. Its presence could increase the difficulty for transvenous lead implantation. We report a 71-year-old woman with an idiopathic dilated cardiomyopathy, atrial fibrillation and heart failure that required bi...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872012000100012

    authors: Vergara SI,Frangini SP,Barrero VR

    更新日期:2012-01-01 00:00:00

  • [Chronic intermittent peritoneal dialysis: a 12-year experience].

    abstract::Since 1981, we have treated 46 adults aged 56 +/- 21 years, of whom 17 were diabetic, with intermittent peritoneal dialysis. Their mean time on dialysis has been 21 months with an accumulated experience of 493 months/patient. The program included 2 dialyses per week, 25 exchanges of 21 per session and 30 min of dwell ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: García R,Gómez M,Olea C,Cuadros K

    更新日期:1995-04-01 00:00:00

  • [Intraoperative monitoring of gastric intramucosal pH].

    abstract:BACKGROUND:Gastric mucosal pH may be a good indicator of splanchnic tissue oxygenation. AIM:To study the effects of abdominal surgical procedures on gastric mucosal pH. PATIENTS AND METHODS:Eighteen patients subjected to abdominal surgery were studied. All patients received general anesthesia and hemodynamic paramete...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Concha M,Añazco R,González A,Becker D,Gajardo A

    更新日期:1996-08-01 00:00:00

  • [Preliminary results of laparoscopic video esophagomyotomy in patients with esophageal achalasia].

    abstract:BACKGROUND:Laparoscopic esophagomyotomy is becoming a good alternative to pneumatic dilatation, injection of botulinic toxin or classical surgery in the treatment of achalasia. AIM:To report the results of laparoscopic esophagomyotomy in patients with achalasia. PATIENTS AND METHODS:Nineteen patients with achalasia, ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Csendes A,Burdiles P,Korn O,Braghetto I,Díaz JC,Henríquez A

    更新日期:2001-10-01 00:00:00

  • [Evaluation of oral anticoagulation with rivaroxaban, in patients with new onset non valvular atrial fibrillation].

    abstract:BACKGROUND:Atrial fibrillation (AF) generates a hypercoagulable state with an increased thrombin generation and raised levels of thrombin-antithrombin complexes, which results in a high risk of stroke and thromboembolism. AIM:To evaluate the anticoagulant effect of rivaroxaban by anti-Xa factor activity and its correl...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872016000900002

    authors: Neira V,Corbalán R,Pereira J,Panes O,Garayar B,Aizman A,Llevaneras S,Villarroel L

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  • [Clinical features of major depressive disorders treated in secondary health care facilities in Chile].

    abstract:BACKGROUND:Depression is considered the second leading cause of disability worldwide. AIM:To describe the clinical characteristics and the evolution of major depressive disorder (MDD) in secondary care. To evaluate the association between socio-demographic and clinic variables with the first or recurrent major depress...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872017000300007

    authors: Salvo L,Saldivia S,Parra C,Rodríguez R,Cifuentes M,Acevedo P,Díaz M,Ormazabal M,Guerra I,Navarrete N,Bravo V,Castro A

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  • [Resistance of human immunodeficiency virus (HIV) to zidovudine. Genotypic analysis in strains isolated from Chilean patients].

    abstract:BACKGROUND:Resistance of HIV to AZT is the result of mutations in the pol gene that codifies the enzyme reverse transcriptase. AIM:To assess the resistance to antiretroviral drugs in Chilean patients infected with HIV. MATERIAL AND METHODS:The presence of mutations was searched in 22 patients infected with HIV. The e...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Vial PA,Vial C,Abarca K,Noriega M,Jiménez G,Labarca J,Gasep J,Palacios O,Pérez C,Acuña G

    更新日期:1998-01-01 00:00:00