[Effects of glycine on auditory evoked potentials among diabetic patients with auditory pathway neuropathy].

Abstract:

BACKGROUND:Glycine inhibits the formation of advanced glycation end products that may cause central and peripheral neuronal damage, affecting also the auditory nerve. AIM:To evaluate the effect of glycine on auditory nerve conduction and hearing level among patients with type 2 diabetes mellitus and auditory neuropathy. MATERIAL AND METHODS:Twenty grams of oral glycine per day were administered during 6 months to 28 type 2 diabetic patients aged 58 ± 6 years, with auditory pathway neuropathy. Hearing tests and evoked otoacustic potentials were performed regularly. Fifteen diabetic patients aged 49 ± 8 years, without auditory nerve neuropathy did not receive glycine and were followed as a control group. RESULTS:Among patients receiving glycine, a significant improvement in left ear audiometry at 125, 250 and 500 Hz and right ear audiometry at 500 Hz, was observed. Waves I, III and V (p= 0.02) of evoked otoacustic potentials improved significantly in the left ear and wave I in the right ear. Among controls, waves V and III of evoked otoacoustic potentials had a significant impairment in the left ear. CONCLUSIONS:There was an improvement in auditory evoked potentials in patients receiving glycine and an impairment in untreated control patients.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Muñoz-Carlin Mde L,Rodríguez-Moctezuma JR,Gómez Latorre JG,Montes-Castillo ML,Juárez-Adauta S

doi

/S0034-98872010001100006

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1246-52

issue

10

eissn

0034-9887

issn

0717-6163

pii

S0034-98872010001100006

journal_volume

138

pub_type

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