Prenatal morphine exposure differentially alters learning and memory in male and female rats.

Abstract:

:The present study tested the hypothesis that exposure to morphine on prenatal days 11-18 impairs performance on tasks requiring learning and memory in adult male and female rats. In Experiment 1, a symmetrical maze was used to measure learning. In Experiment 2, an eight-arm radial maze was used to assess working spatial memory. The results of Experiment 1 demonstrated that prenatal morphine exposure reduces the time needed to complete the trials, but does not affect the accuracy of performance in male rats. In contrast, prenatal drug treatment had no effects on either the time or the accuracy of performance in female rats. In Experiment 2, both male and female morphine-exposed rats needed more time to complete regular trials (no delay) than controls; however, morphine exposure in male rats did not affect performance on tasks requiring memory, measured with delay trials, but hindered it in ovariohysterectomized (OVX) female rats. In OVX females, replacement injections of both estrogen and progesterone restored the impairment of performance on delay trials produced by prenatal morphine exposure. Thus, the present study demonstrates that prenatal morphine exposure differentially alters performance of adult male and female rats on tasks requiring learning and spatial memory.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Slamberová R,Schindler CJ,Pometlová M,Urkuti C,Purow-Sokol JA,Vathy I

doi

10.1016/s0031-9384(01)00469-3

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

93-103

issue

1-2

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(01)00469-3

journal_volume

73

pub_type

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