Abstract:
:Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.
journal_name
Cell Transplantjournal_title
Cell transplantationauthors
Fernandez LA,Romaguera R,Viciana AL,Ruiz P,Tzakis AG,Ricordi Cdoi
10.1016/0963-6897(96)00026-7subject
Has Abstractpub_date
1996-07-01 00:00:00pages
513-6issue
4eissn
0963-6897issn
1555-3892pii
0963689796000267journal_volume
5pub_type
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