Abstract：
:To measure serum soluble transferrin receptor (s-TfR) levels in patients with rheumatoid arthritis (RA), sera were obtained from 50 Japanese RA patients and 20 healthy subjects. Both s-TfR and serum erythropoietin (EPO) levels were measured by enzyme-linked immunosorbent assay (ELISA). Routine laboratory tests were also performed, including peripheral blood analysis and determination of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), serum iron levels, total iron-binding capacity (TIBC) and serum ferritin levels. The s-TfR levels in the 50 RA patients (mean +/- SD, 1,801 +/- 512 ng/ml) were significantly higher than those in the 20 control subjects (1,316 +/- 345 ng/ml). There were no differences in the values of s-TfR between men and women in either group, or between RA patients over and under 50 years old. Serum EPO levels in 47 RA patients were as low as 14.0 +/- 10.1 mlU/ml (mean +/- SD), ranging from 3.9 to 58.7 mIU/ml (normal range 2.8-17.2 mlU/ml), unrelated to low haemoglobin concentration. The s-TfR levels in RA patients showed negative correlations with red blood cell count, serum iron level and haemoglobin concentration, and positive correlations with ESR and serum EPO levels. However, there were no correlations between s-TfR level and markers of inflammation such as CRP, platelet count or RF titre. In conclusion, s-TfR level in RA patients could be a marker of erythropoiesis rather than of joint inflammation.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Chijiwa T,Nishiya K,Hashimoto Kdoi
10.1007/s100670170018subject
Has Abstractpub_date
2001-01-01 00:00:00pages
307-13issue
5eissn
0770-3198issn
1434-9949journal_volume
20pub_type
临床试验,杂志文章abstract：:Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2127-9
更新日期：2013-03-01 00:00:00
abstract：:A case of left brachial plexus compression by an iatrogenic arteriovenous fistula was treated by detachable balloon technique with immediate relief of pain. Good results on paresia were obtained in a few weeks. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02330599
更新日期：1987-12-01 00:00:00
abstract：:Anti-tumour necrosis factor alpha therapy has led to significant advancement in the treatment of rheumatological disease. Rarely, anti-TNFalpha antagonists have been associated with vasculitis, predominantly cutaneous leukocytoclastic vasculitis. We present the first case of angiographically-confirmed digital vasculit...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-1015-9
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:Patients with axial spondyloarthritis (SpA) are subjected to elevated cardiovascular risks, but assessment of early myocardial damage and clinical risk stratification remained obscure. The aim of this study was to evaluate the prognostic value of speckle-tracking strain analysis and serum high-sensitivity tro...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05112-5
更新日期：2020-11-01 00:00:00
abstract：:Takayasu arteritis (TA) is a chronic inflammatory disease. Interleukin (IL)-6 and IL-10 are important cytokines involved in the immune response of TA in some ethnicities. We investigated whether the single-nucleotide polymorphism (SNP) of IL-6 and IL-10 genes and their expressions were associated with TA in a Chinese ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4260-6
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To assess whether systemic sclerosis (SSc) is associated with total knee arthroplasty (TKA) outcomes. METHODS:We used the 1998-2014 US National Inpatient Sample. We conducted multivariable-adjusted logistic regression analyses to examine the association of a diagnosis of SSc with post-TKA in-hospital complic...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04754-4
更新日期：2020-01-01 00:00:00
abstract：:There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-013-2342-z
更新日期：2013-11-01 00:00:00
abstract：:To characterize the distinctive chest high-resolution computerized tomography (HRCT) features and clinical manifestations of primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD). The demographic data, clinical manifestations, and laboratory and radiological findings of 527 pSS patients were retrospec...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4289-6
更新日期：2018-11-01 00:00:00
abstract：:The pharmacokinetic profile of a single 10 mg oral dose of prednisolone was studied in three groups of six patients with rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and bronchial asthma (BA) who were already receiving steroid therapy. A fourth group of age and sex-matched normal controls was also studied. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02054250
更新日期：1986-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1599-8
更新日期：2011-05-01 00:00:00
abstract：:Systemic sclerosis (SSc) is complicated by pulmonary hypertension and right ventricle (RV) failure in approximately 10% of the patients. Factors influencing the reactivity of pulmonary circulation to vasodilators are not established, while the examination of vasoreactivity is important in determining the treatment, be...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1792-4
更新日期：2012-01-01 00:00:00
abstract：:Antiglomerular basement membrane antibody disease (aGD) remains a very uncommon entity in the pediatric population, characterized by pulmonary hemorrhage, glomerulonephritis, and antibodies against the glomerular basement membrane. We herein describe the case of a 14-year-old girl with primary pulmonary symptoms diagn...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-012-2062-9
更新日期：2012-12-01 00:00:00
abstract：:In order to assess the clinical equivalence between deflazacort oral drops and tablets, 18 patients with active rheumatoid arthritis were enrolled in an open, controlled, randomised ('tablets --> drops' sequence, or vice versa), two-period (21 days each) crossover trial (from tablets to drops, or vice versa). Individu...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s100670050072
更新日期：1999-01-01 00:00:00
abstract：:To compare rheumatologists' adherence to treatment protocols for rheumatoid arthritis (RA) targeted at Disease Activity Score (DAS) ≤2.4 or <1.6. The BeSt-study enrolled 508 early RA (1987) patients targeted at DAS ≤2.4. The IMPROVED-study included 479 early RA (2010) and 122 undifferentiated arthritis patients target...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10067-016-3405-8
更新日期：2017-02-01 00:00:00
abstract：:Heart rate variability (HRV) gives information about sympathetic parasympathetic autonomic balance. Our purpose was to determine whether HRV is abnormal in patients with Sjögren's syndrome. In 16 patients with Sjögren's syndrome and 30 matched controls, a short time analysis of HRV was performed for both the frequency...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/pl00011180
更新日期：2000-01-01 00:00:00
abstract：:Amyloidosis in association with Systemic Lupus Erythematosus (SLE) has rarely been reported. We report a patient with "SLE" and Amyloidosis presenting with recurrent bloody diarrhea and review the relevant literature. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02242463
更新日期：1997-06-01 00:00:00
abstract：:Two cases of systemic lupus erythematosus (SLE) with autoimmune hepatitis are reported. Both patients had a mild form of SLE without central nervous system or renal involvement and showed a rapid response to corticosteroid therapy. Neither of them had antibodies to mitochondria, smooth muscle, and liver/kidney microso...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02238968
更新日期：1997-05-01 00:00:00
abstract：:We investigated the occurrence of an active cytomegalovirus (CMV) infection in patients with polyarteritis nodosa (PAN). Eleven patients with PAN were screened for the presence of CMV-DNA in their blood using the polymerase chain reaction (PCR). Serum anti-CMV IgG and anti-CMV IgM antibodies were determined by enzyme-...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050148
更新日期：1999-01-01 00:00:00
abstract：:As a class, tumor necrosis factor (TNF)-alpha inhibitors have provided clinicians significant control over chronic inflammatory diseases. With their widespread use has come the emergence of new side effects such as the reactivation of latent infections. One such infection that may reactivate is the hepatitis B virus (...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-010-1523-2
更新日期：2010-09-01 00:00:00
abstract：:We report a case of a 56-year-old woman with an alleged diagnosis of an acute coronary syndrome that was later correctly identified in our Cardiology Unit as antisynthetase syndrome (AS) with inflammatory cardiac involvement. In this case report, we focus on clinical features of this rare autoimmune disease aiming to ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-019-04527-z
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To investigate the association between disease activity and cognitive impairment in patients with rheumatoid arthritis (RA). METHODS:A total of 464 patients from the rheumatoid arthritis registry of two academic centers, Siriraj and Phramongkutklao hospitals, were included. Demographic, clinical, and laborat...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-019-04488-3
更新日期：2019-07-01 00:00:00
abstract：:The aims of the study were to assess the health-related quality of life (QOL) in patients with Takayasu's arteritis (TA) by two different generic QOL instruments and to compare the results with those patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and healthy controls (HC). A cross-sectional stud...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0813-9
更新日期：2008-07-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0049-5
更新日期：2006-05-01 00:00:00
abstract：:Severe thrombocytopenia with bleeding associated with a life-threatening thrombotic manifestation in the setting of antiphospholipid syndrome is a major diagnostic and therapeutic challenge for the clinician. Hemorrhage is a less common complication than thrombosis in patients with APS, although severe thrombocytopeni...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-013-2416-y
更新日期：2014-04-01 00:00:00
abstract：:Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4010-9
更新日期：2018-10-01 00:00:00
abstract：:The prostaglandin series of bioactive compounds is formed by the interaction of two distinct but related enzymes, cyclo-oxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 is a constitutive form which is present mainly in the gastric mucosa, kidney and platelets. COX-2 is mainly an inducible form, although also to...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s100670070024
更新日期：2000-01-01 00:00:00
abstract：:The objective of the study was to determine clinical factors associated with activity limitation and predictors of a change in activity limitation after 1 year in people with gout. Two hundred ninety-five participants with gout (disease duration < 10 years) attended a baseline assessment which included medical and dis...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4110-6
更新日期：2018-08-01 00:00:00
abstract：:Reduced physical function and health-related quality of life are common in rheumatoid arthritis (RA), and further studies are needed that examine novel determinates of reduced physical function in RA. This study examines whether frailty, a state of increased vulnerability to stressors, is associated with differences i...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-017-3541-9
更新日期：2017-05-01 00:00:00
abstract：:Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement mol...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-008-0838-8
更新日期：2008-04-01 00:00:00
abstract：:Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02114402
更新日期：1990-09-01 00:00:00
