Abstract：
BACKGROUND:Late graft failure is still a problem for vascular surgeons. A previous study showed superior patency of arterial grafts compared with venous grafts. In this review we discuss the differences in functional and morphologic modulation of experimental autogenous venous and arterial grafts. RESULTS:In canine venous grafts, the endothelium of the graft was denuded and recovered within 3 or 4 weeks. In contrast, in arterial grafts, denudation of the endothelium was minimal, and no platelet adherence was observed. Instead, nearly normal intact endothelial cell surface had covered the intima within 3 days after grafting. The histologic findings for arterial grafts thus were quite different from those for venous grafts. Different responses to flow changes between venous and arterial grafts were observed. In the venous grafts, pronounced intimal thickening was associated with impairment of endothelial responses, whereas in the arterial grafts, intact endothelial function and no intimal thickening were observed. CONCLUSIONS:The intact endothelial function and absence of intimal thickening under the arterial grafts may explain the superior patency of autogenous arterial grafts in comparison with venous grafts.
journal_name
Surgeryjournal_title
Surgeryauthors
Komori K,Inoguchi H,Kume M,Shoji T,Furuyama Tdoi
10.1067/msy.2002.119797subject
Has Abstractpub_date
2002-01-01 00:00:00pages
S249-55issue
1 Suppleissn
0039-6060issn
1532-7361pii
S0039-6060(02)98962-2journal_volume
131pub_type
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