Abstract：
BACKGROUND:Nosocomial pneumonia (NP) in injured patients is a significant clinical problem. We hypothesize that the pathogenesis of NP in injured patients involves an imbalanced cytokine response within the alveolar airspace that may inhibit effector cell function. METHODS:Proinflammatory (IL-8) and anti-inflammatory (IL-10) levels were measured in bronchoalveolar lavage (BAL) fluid from multitrauma patients on admission, 24, 48, and 72 hours post-injury and following lipopolysaccharide (LPS) induction of alveolar cells. Patients were compared based on IL-8 levels and the development of NP. RESULTS:A high level of IL-8 on admission was associated with the development of NP. In addition, levels of IL-8 were significantly greater in NP-positive patients at all time points. The IL-10 levels decreased from admission values in NP-negative patients but increased in NP-positive patients. Furthermore, a high level of IL-10 ( > 120 pg/mL) at 72 hours post-injury was associated with the development of NP. Alveolar cells from NP-positive patients produced significantly more IL-10 in response to LPS than cells from NP-negative patients. CONCLUSIONS:The pathogenesis of NP in injured patients involves an early and severe IL-8 process within the lung followed by an exaggerated IL-10 response that may inhibit effector cell function.
journal_name
Surgeryjournal_title
Surgeryauthors
Muehlstedt SG,Richardson CJ,West MA,Lyte M,Rodriguez JLdoi
10.1067/msy.2001.117105subject
Has Abstractpub_date
2001-10-01 00:00:00pages
602-9; discussion 609-11issue
4eissn
0039-6060issn
1532-7361pii
S0039-6060(01)25951-0journal_volume
130pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:The objectives of the present study are to determine the long-term changes in glucose tolerance function after pancreaticoduodenectomy and to compare the effects of pancreaticojejunostomy (PJ) and pancreaticogastrostomy (PG). Patients and methods The present study consisted of 51 patients who received a panc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.01.006
更新日期：2004-09-01 00:00:00
abstract：:Transplantation of the pancreaticoduodenal allograft (PDA) has recently been advocated as a technique that is superior to the use of the segmental allograft. However, the effect of simple cold storage preservation on the PDA has not been studied. We investigated the effect of 24 and 4 hours of cold storage in Eurocoll...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-02-01 00:00:00
abstract：:Multifocal colonic carcinoma occurred in a 65-year-old man with a 13 year history of colonic Crohn's disease. The relationship between solitary and multiple colonic cancer and Crohn's disease is discussed. ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-10-01 00:00:00
abstract：BACKGROUND:The long-term outcome of bilateral adrenalectomy in the management of patients with Cushing's syndrome has not been previously well studied. METHODS:We reviewed our long-term results in 34 patients treated with bilateral adrenalectomy between 1983 and the present. Fourteen presented with occult or metastati...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:The role of routine central lymph node dissection (CLND) for papillary thyroid cancer (PTC) remains controversial. The aim of this study was to evaluate the impact of routine CLND after total thyroidectomy (TTx) in the management of patients with PTC who were clinically node negative at presentation with emp...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.surg.2011.09.003
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:The relationship among bile duct (BD), portal vein (PV), and/or hepatic artery (HA) anatomy is controversial, but no investigation has previously compared left and right liver graft transplantation in terms of variant vasculobiliary anatomy. Therefore, in this study, we explored whether variant BD anatomy ca...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.06.017
更新日期：2010-01-01 00:00:00
abstract：:This study evaluated two changes in fluorometric assessment of fluorescein dye delivery: (1) monitoring the proportional, rather than the absolute, increase above the preinjection background reading at each site to obviate the effect of skin color and (2) employing gradual means of dye administration to facilitate mon...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:This study compares the effects of carbon dioxide pneumoperitoneum versus laparotomy on cellular-mediated immune response in a murine model. METHODS:Sixty-eight female C3H/He mice were sensitized to keyhole limpet hemocyanin (KLH) and to a mouse mammary carcinoma cell line (MC2) before surgery. Animals were...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.101152
更新日期：2000-01-01 00:00:00
abstract：:The Consortium of American College of Surgeons-Accredited Education Institutes was created to explore new opportunities in simulation-based surgical education and training beyond the scope of individual accredited institutes. During the Third Annual Meeting of the Consortium of American College of Surgeons-Accredited ...
journal_title：Surgery
pub_type：
doi：10.1016/j.surg.2010.11.010
更新日期：2011-06-01 00:00:00
abstract：:Four hundred forty-one patients who were operated on for primary hyperparathyroidism were observed for up to 22 years. Mortality was significantly higher than expected during the first postoperative years, for both men and women. This was predominantly due to a higher than expected incidence of diseases of the circula...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：UNLABELLED:In patients undergoing pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PC), conversion to total pancreatectomy (TP) may be necessary to achieve R0 resection. HYPOTHESIS:We sought to examine the oncologic benefit of conversion of PD to TP to achieve an R0 resection in patients with an isolated po...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.07.016
更新日期：2007-10-01 00:00:00
abstract：:One hundred five students in our surgical clerkship were evaluated independently by two faculty members, a chief resident, a written multiple-choice examination, and two oral examinations. Faculty and chief resident evaluations included a written explanation and a score from 1 (honors) to 5 (failing). Oral and written...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：:Ectopically placed parathyroid adenomas have been described in many locations. This article documents two patients in whom the adenoma was present in the lateral triangle of the neck, outside of the carotid sheath, and lateral to the jugular vein. ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:In primary hyperparathyroidism, successful parathyroidectomy leads to improved bone mineral density in the majority of cases. Our aim was to further explore the relationship between hypercalciuria, kidney function, and bone recovery after parathyroidectomy. METHODS:Bone mineral density, estimated glomerular...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2017.02.017
更新日期：2017-08-01 00:00:00
abstract：:Several clinical studies have documented an increased incidence of gallstones after truncal vagotomy. Previous laboratory studies, however, have failed to establish a clear mechanism for this phenomenon. Whereas lithogenic bile is a prerequisite for cholesterol cholelithiasis, gallbladder stasis has also been shown to...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：BACKGROUND:Managing postoperative electrolyte imbalances often is driven by dogma. To identify areas of improvement, we assessed the practice pattern of postoperative electrolyte management among surgeons and residents. STUDY DESIGN:An online survey was distributed among attending surgeons and surgical residents at th...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.02.014
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Somatostatin analogues inhibit peptide release and cell growth through multiple postreceptor signal transduction mechanisms (PRSTM), including G proteins (GP), cyclic adenosine monophosphate (cAMP), calcium, protein kinase C (PKC), and tyrosine phosphatase (TP). Octreotide acetate (OA), a somatostatin analog...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:Our previous work classified a taxonomy of suturing gestures during a vesicourethral anastomosis of robotic radical prostatectomy in association with tissue tears and patient outcomes. Herein, we train deep learning-based computer vision to automate the identification and classification of suturing gestures ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.08.016
更新日期：2020-09-26 00:00:00
abstract：:Plasma lipid and lipoprotein levels and composition of the very low-, low-, and high-density lipoproteins (VLDL, LDL, HDL) were studied in white New Zealand rabbits in the control state, 8 weeks after initiation of a 2% cholesterol-enriched diet, and sequentially for 16 weeks following a partial ileal bypass (PIB) pro...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-02-01 00:00:00
abstract：BACKGROUND:Statewide trauma systems are implemented by health care policy makers whose intent is to improve the process of care delivered to seriously injured patients. In Oregon, Advanced Trauma Life Support (ATLS) training was mandated for all physicians employed in the emergency department of trauma centers. The pur...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1067/msy.2001.115898
更新日期：2001-08-01 00:00:00
abstract：:The intestinal epithelium normally provides a barrier function that prevents absorption of potentially harmful materials from the intestinal lumen. It has been postulated but never demonstrated that a cutaneous thermal injury will result in increased small-intestinal permeability. In a standardized 20% body surface ar...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:The current study was designed to determine the effects of antibody blockade of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) on the proinflammatory activity of mesenteric lymph after hemorrhagic shock and resuscitation (HS/R). METHODS:Rats were subjected to HS/R with or without treatment with MAdCA...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.12.013
更新日期：2016-05-01 00:00:00
abstract：:Nelson's syndrome--progressive cutaneous hyperpigmentation with x-ray film evidence of an expanding pituitary tumor--is now a well-recognized sequela of bilateral adrenalectomy for Cushing's disease. It is estimated to occur in 8% to 38% of adults. Because Cushing's disease is rare in children, a higher incidence of N...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:This study was conducted to determine if team training using a federally sponsored team training program improves operating room (OR) performance and culture. METHODS:The TeamSTEPPS program, a team training program designed and tested for health care applications, was provided to the OR staff. The training ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.07.076
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Recent studies suggest that low computed tomography (CT) attenuation values can be used to differentiate benign adrenal adenomas from non-adenomas. We examined the utility of non-enhanced CT attenuation values of journal_title：Surgery pub_type： 杂志文章 doi：10.1067/msy.2001.119189 更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Several studies have demonstrated that postoperative complications after pancreatectomy for pancreatic cancer adversely affect survival. The impact on survival of a pancreatic fistula according to the classification of the International Study Group for Pancreatic Surgery has not been fully evaluated. The aim...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.surg.2016.02.032
更新日期：2016-08-01 00:00:00
abstract：:Percutaneous drainage (PCD) of abdominal infection is a therapeutic modality whose role is not well defined. Surgical literature on abdominal infection cites a cumulative mortality rate in the range of 20% to 30%, markedly dissimilar from the 80% to 90% cure rates reported in the literature on PCD. We reviewed the PCD...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:Surgical wrapping (SW) of the pancreas causes islet neogenesis in rodents. Pancreatic duodenal hoemobox-1 (PDX-1) is one of the transcriptional factors needed by pancreatic stem cells to develop a mature pancreas. The purpose of this study was to determine whether islet neogenesis arises from ductal cells an...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(03)00394-5
更新日期：2004-03-01 00:00:00
abstract：:Minced adult human, rat, and dog pancreatic fragments were cultured under various conditions in an attempt to selectively purify pancreatic islet tissue from exocrine digestive enzymes. Islet purification was assessed by measuring tissue insulin and amylase concentrations, proportional to islet beta cell mass and exoc...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：BACKGROUND:The development of effective gene transfer in utero will provide alternative approaches to the treatment of genetic disorders. For many disorders, the fetal liver and peritoneum are important target tissues. Our goals were to compare the tissue sites and duration of transferred gene expression after intraper...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
