Abstract：
BACKGROUND:Although fine-needle aspiration (FNA) is 90% sensitive in the detection of papillary carcinoma (PC) of the thyroid, its specificity has been reported as low as 52%. Consequently, patients who have an FNA suspicious for PC may undergo operation for a benign process. The ribonucleoprotein telomerase has been noted to be activated in a wide variety of carcinomas. We examined 30 PCs for telomerase activity to determine whether this would be a useful adjunct to FNA in the diagnosis of lesions suspicious for PC. METHODS:Standard telomere repeat amplification protocol assays were performed on fresh frozen tissue samples from 30 PCs, 3 benign nodules, and 10 normal thyroids. RESULTS:Telomerase activity was documented in 20 of 30 (67%) of the PCs, 0 of 3 benign nodules, and 0 of 10 normal thyroids. In all, 11 of the 20 PCs had FNA cytology that was nondiagnostic of PC, and 2 of the benign nodules had FNA that was suspicious for PC. CONCLUSIONS:The telomerase assay appears useful in the distinction of benign from malignant thyroid lesions that have FNA suspicious for but not diagnostic of PC. On the basis of these findings, a prospective trial examining telomerase activity in FNAs suspicious for thyroid cancer has been initiated.
journal_name
Surgeryjournal_title
Surgeryauthors
Saji M,Westra WH,Chen H,Umbricht CB,Tuttle RM,Box MF,Udelsman R,Sukumar S,Zeiger MAdoi
10.1016/s0039-6060(97)90219-1subject
Has Abstractpub_date
1997-12-01 00:00:00pages
1137-40issue
6eissn
0039-6060issn
1532-7361pii
S0039-6060(97)90219-1journal_volume
122pub_type
杂志文章相关文献
SURGERY文献大全abstract：:Among 2411 consecutive arterial reconstructions performed with synthetic prosthetic material in Denmark during a 4-year period, 62 patients (2.6%) developed graft infection. Graft infection occurred only when the groin had been incised. The incidence of infection and the spread of infection along the graft did not rel...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：BACKGROUND:The benefit of adding external beam radiation to adjuvant chemotherapy in patients that have undergone a margin positive resection for early stage, pancreatic ductal adenocarcinoma has not been determined definitively. METHODS:The National Cancer Data Base was queried to evaluate the utility of adjuvant rad...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.09.022
更新日期：2018-05-01 00:00:00
abstract：:Autonomously functioning thyroid nodules (AFTNs) in children and adolescents (under age 18) are unusual but are not as rare as earlier reports suggested. These lesions have a significantly different biologic potential than similar lesions in older patients. In the younger age group there is a more rapid progression to...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:The utility of fine-needle aspiration biopsy to detect carcinoma in thyroid nodules was evaluated by a decision-analysis approach in 102 patients. The procedure caused no morbidity. Cytologic diagnoses were categorized as unsatisfactory (4), no abnormality detected (61), atypical (13), suspicious for malignancy (14), ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:Ischemia and reperfusion lead to eicosanoid- and neutrophil (PMN)-dependent injury. This study tests the role of ischemia-induced lipoxygenase activity in mediating PMN activation and diapedesis. Anesthetized rabbits (n = 8) underwent 3 hours of bilateral hindlimb ischemia. At 10 minutes of reperfusion, leukotriene B4...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:In patients with esophageal cancer and a history of gastric surgery, colonic interposition is the treatment of choice. Our aim was to review our experience with this technique and to identify possible predictors of the clinical outcome. METHODS:Between 1986 and 2006, 43 patients underwent esophageal reconst...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.10.045
更新日期：2010-04-01 00:00:00
abstract：:To determine the relative value of carotid phonoangiography (CPA), oculoplethysmography-Kartchner (OPG-K), and Doppler ultrasonic arteriography (UA), 90 vessels undergoing carotid endarterectomy were prospectively examined. By analyzing the data on receiver operator characteristic curves, the dynamic relationship betw...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:The risk of invasive cancer in resected intraductal papillary mucinous neoplasm with main pancreatic duct involvement is 33%-60%. Most guidelines, therefore, advise resection of main duct intraductal papillary mucinous neoplasm and mixed type intraductal papillary mucinous neoplasm in surgically fit patients...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.01.025
更新日期：2018-05-16 00:00:00
abstract：BACKGROUND:Preconditioning is injury-induced protection against subsequent injury and may be induced by a variety of stimuli. Both males and females may be preconditioned; however, if females are relatively protected against the initial insult, is their preconditioning threshold higher? We hypothesized that preconditio...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.03.016
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Resection for hepatocellular carcinoma in patients with cirrhosis and impaired liver function is usually unjustified because of higher surgical risks and poorer long-term prognosis. METHODS:A retrospective comparison of the background and resectional results of patients with cirrhosis and hepatocellular car...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80238-8
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Obesity and type 2 diabetes are associated with renal dysfunction, which improves after Roux-en-Y gastric bypass (RYGB). During a 12-month follow-up period, we studied prospectively the changes in glomerular and tubular functions that occurred in excessively obese diabetic and non diabetic subjects after RYG...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.09.017
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Patient-reported outcomes are measured in chronic disease states to inform intervention and management decisions while minimizing negative outcomes. We hypothesized that health-related quality of life in patients with multiple endocrine neoplasia type 2A would be worse than the general US population but simi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.04.036
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Rib fractures are common and associated with significant pulmonary morbidity. We hypothesized that epidural analgesia would provide superior pain relief, and reduce the risk of subsequent pneumonia. METHODS:A prospective, randomized trial of epidural analgesia versus IV opioids for the management of chest w...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.surg.2004.05.019
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:"Take the Volume Pledge" proposes restricting pancreatectomies to hospitals that perform ≥20 per year. Our purpose was to identify those factors that characterize patients at risk for loss of access to pancreatic cancer care with enforcement of volume standards. METHODS:Using the Healthcare Cost and Utiliza...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.07.017
更新日期：2017-03-01 00:00:00
abstract：:Computed tomography was used to evaluate 25 hemodynamically stable patients with suspected leaking abdominal aortic aneurysms. Of 10 patients found to have the presence of free retroperitoneal blood, six underwent immediate operation and five survived (83%). Delay in operation uniformly resulted in death. There was on...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:In anticipation of developing gene therapy against thyroid carcinoma we created an expression vector using the thyroglobulin (Tg) gene promoter. The inhibition of both Tg and thyroid-specific transcription factor (TTF-1 and PAX-8) gene expression, however, has been well documented in thyroid carcinomas. We t...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.1998.92008
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Hypoparathyroidism is the most frequent permanent complication of thyroid surgery. Our hypothesis is that human precursor cells in culture can be differentiated into parathyroid cells and used to reconstitute function. Human embryonic stem cells (hESCs) are a stable model to study differentiation into parath...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.09.021
更新日期：2010-12-01 00:00:00
abstract：:During the recent 5 2/3 years, hepatic resection was performed on 118 patients with hepatocellular carcinoma. Ages ranged from 17 to 78 years with an average of 57 years. There were 101 males and 17 females. Underlying cirrhosis of the liver was found in 101 cases, and chronic hepatitis was found in 16 cases. Before s...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:Mechanical anastomosis has been claimed to reduce the rate of leakage compared with manual anastomosis. No randomized trials have been performed to date to prove this specifically in esophagogastric anastomosis. METHODS:One hundred fifty-four patients, 139 men and 15 women ranging in age from 36 to 83 years...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0039-6060(96)80066-3
更新日期：1996-09-01 00:00:00
abstract：:In a 2-year period 30 patients with persistent hyperparathyroidism following 59 prior unsuccessful procedures underwent reoperation. Preoperative arteriography was useful in planning the surgical approach in 56%, and retrospectively was correct in 63%. Selective venous catheterization gave localizing information in 83...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
abstract：:The deep inferior epigastric artery and vein may be satisfactorily utilized for chronic hemodialysis in patients who have no extremity vessels available. ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-11-01 00:00:00
abstract：BACKGROUND:This study compares the effects of carbon dioxide pneumoperitoneum versus laparotomy on cellular-mediated immune response in a murine model. METHODS:Sixty-eight female C3H/He mice were sensitized to keyhole limpet hemocyanin (KLH) and to a mouse mammary carcinoma cell line (MC2) before surgery. Animals were...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.101152
更新日期：2000-01-01 00:00:00
abstract：:Endorectal ileoanal anastomosis with proximal interposition of an ileal reservoir was evaluated experimentally in dogs as an approach to retain sphincteric control of defecation after proctocolectomy. Two months after the operative procedure, eight animals with a reservoir had four to eight semisolid stools per day an...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:A report of a 38-year-old man with a 10 month course of illness characterized by recurrent pericardial and pleural high-protein, high-amylase effusions is presented. Operative pancreatogram demonstrated fistulization from the mid-pancreas through the mediastinum into both pleural spaces and the pericardium. Surgical d...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：BACKGROUND:Statewide trauma systems are implemented by health care policy makers whose intent is to improve the process of care delivered to seriously injured patients. In Oregon, Advanced Trauma Life Support (ATLS) training was mandated for all physicians employed in the emergency department of trauma centers. The pur...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1067/msy.2001.115898
更新日期：2001-08-01 00:00:00
abstract：:Deficiencies in the immune system that lead to increased morbidity and mortality from infectious complications have been well documented in patients suffering from trauma, malnutrition, sepsis, and thermal injuries. We investigated the potential benefit of immune stimulation for preventing infection in such conditions...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:Glucagon-like peptide-2 induces small intestine mucosal epithelial cell proliferation and may have benefit for patients who suffer from short bowel syndrome. However, glucagon-like peptide-2 is inactivated rapidly in vivo by dipeptidyl peptidase IV. Therefore, we hypothesized that selectively inhibiting dipe...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.05.013
更新日期：2011-08-01 00:00:00
abstract：:Patients with stages O and I malignant melanomas of the trunk and proximal limbs, having had wide excisions only without lymph node dissections, were reviewed to determine whether the presence or absence of muscle fasciae correlated with prognosis. Prior to 1969 most patients seen at The University of Texas M. D. Ande...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:Breast milk has been shown to prevent gut-origin infections in neonates through undefined mechanisms. Putative protective factors in breast milk include immunoglobulin (Ig)A, IgG, and lactoferrin. We examined their role in bacterial translocation in neonatal rabbits. METHODS:IgA, IgG, and lactoferrin were i...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:Aspiration devices can persistently malfunction if moderate (not just high) suction causes mucosal occlusion of every opening. The standard pattern of uniformly large orifices was modified by supplementing half the nasal tubes with smaller (one tenth of the area) openings. Ten pairs of postoperative patients sipped wa...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
