Abstract:
BACKGROUND:Preconditioning is injury-induced protection against subsequent injury and may be induced by a variety of stimuli. Both males and females may be preconditioned; however, if females are relatively protected against the initial insult, is their preconditioning threshold higher? We hypothesized that preconditioning injury threshold differences may exist between genders, which may be associated with differences in myocardial inflammatory monokine production. METHODS:Male and female Sprague-Dawley rats (n=3-5/group) were given intraperitoneal injections of 125 or 500 microg/kg Salmonella typhimurium lipopolysaccharide (ETX) or 0.4 mL normal saline (NS; 154 mmol/L NaCl). After 24 hours, another injection of 500 microg/kg ETX (injury dose) or NS was given, and the animals were incubated an additional 1 or 6 hours. The rats were anesthetized and myocardial function evaluated via the Langendorff perfusion model. Tumor necrosis factor-alpha (TNF-alpha), interleukin-(IL)-1beta, and IL-6 were measured in 1-hour animals via an enzyme-linked immunosorbent assay. Nonpreconditioned rats (PC-) received NS followed by ETX. Preconditioned rats received either 125 microg/kg ETX (PC+125) or 500 microg/kg ETX (PC+500) followed by injury dose ETX. RESULTS:PC+125 and PC+500 males, as well as PC+500 females, were preconditioned and retained cardiac function similar to shams. PC+125 females were not preconditioned with this stimulus and had a decrease in cardiac function similar to PC- rats. Furthermore, PC+125 and PC+500 males, and PC+500 females had decreased release of TNF-alpha after preconditioning, while PC- animals and PC+125 females did not. CONCLUSIONS:Males and females can be preconditioned by endotoxin; however the preconditioning threshold is higher in females than males.
journal_name
Surgeryjournal_title
Surgeryauthors
Pitcher JM,Tsai BM,Wang M,Kher A,Brown JW,Meldrum DRdoi
10.1016/j.surg.2005.03.016subject
Has Abstractpub_date
2005-08-01 00:00:00pages
223-8issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(05)00197-2journal_volume
138pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle al...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.01.017
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Endoscopic endocrine neck surgery requires insufflation with carbon dioxide (CO(2)) at 10 to 15 mm Hg, which may decrease the cerebral venous return and increase intracranial pressure. This study evaluated the effect of CO(2) neck insufflation on intracranial pressure (ICP) and hemodynamic parameters. METHO...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.110238
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:We determined whether hepatic intra-arterial infusion of 5-fluorouracil (5-FU) in patients with synchronous hepatic metastases from colorectal cancer, in whom the primary lesion was resectable but hepatic metastatic lesions were non-resectable helped improve survival time when administered on the basis of the...
journal_title:Surgery
pub_type: 临床试验,杂志文章
doi:10.1016/j.surg.2006.03.001
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The relationship between myopenia, nutritional status, and long-term oncologic outcomes remains poorly characterized in patients with clinically resectable pancreatic cancer. We sought to reliably quantify prognostic indicators of preoperative cachexia in a manner applicable to any clinical setting. METHODS...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.09.038
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:Policies that mandate colorectal screening coverage by private insurers are associated with increased use of screening procedures. We seek to understand whether such mandates have improved access to care and short-term operative outcomes for patients undergoing operations of the colon and rectum (OCR). ME...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.04.037
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Routine, whole-body computed tomography imaging (PAN-SCAN) has been shown to identify unexpected injuries and alter the management of patients presenting with blunt trauma. We sought to characterize the changes in practice over time and the utility of PAN-SCAN imaging in elderly patients who fall and requi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.07.015
更新日期:2013-10-01 00:00:00
abstract::We estimated ambulatory venous pressure (AVP) noninvasively with a new technique of quantitative photoplethysmography (PPG). Postural changes of hydrostatic pressure permitted in vivo calibration of the PPG. We recorded quantitative PPG and AVP in 14 normal subjects and 14 patients with postthrombotic chronic venous i...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::Surgical education has been exposed to increasing challenges as students have moved from the highly structured environment of a university hospital into a variety of clinical settings within the community. Presented with a general surgical service that uses ten relatively autonomous teaching services in seven hospital...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:We have demonstrated that gastrin-releasing peptide (GRP) binds specifically to its cell surface receptor, GRP-R, to act as an autocrine/paracrine growth factor for neuroblastomas (NBs); an increased expression of GRP-R was found in more advanced-stage NBs. Ets family proteins are nuclear targets for intrace...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.05.030
更新日期:2004-08-01 00:00:00
abstract::Forty-seven patients with 50 clinically occult injuries of major arteries were studied prospectively to determine the natural history of these lesions and the safety of nonoperative management. Penetrating trauma was the predominant mechanism and lower extremity arteries were most commonly involved. The morphology of ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Duodenobronchial fistulas are an extremely rare subgroup of abdominobronchial fistulas, which include bronchobiliary, gastrobronchial, enterobronchial, colobronchial, and splenobronchial fistulas. Only one case of a duodenobronchial fistula has been previously reported. Duodenobronchial fistulas occur as a complicatio...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract::Palliative care has long been described in medical literature but only recently is being discussed in the surgical domain. Mounting evidence suggests that early integration of palliative care improves patient outcomes and this is especially true of oncology patients. Thus, the pendulum is swinging toward recognizing t...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.10.001
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Hilar resection, especially in combination with liver resection, results in substantial morbidity and mortality, which clearly influences the overall outcome. In the present study, patients who underwent resection of a proximal bile duct tumor were analyzed with the aim of identifying risk factors for morbid...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.104250
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:A left hepatic graft in living donor liver transplantation (LDLT) often has 2 thin and short hepatic arterial stumps, which makes hepatic artery (HA) reconstructions much more difficult to perform. Consequently, some investigators regard using a left graft as a contraindication to LDLT, whereas others report...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.06.028
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the incidence of complications in the upper limbs as a new event after radial artery (RA) harvesting for coronary artery bypass grafting (CABG). METHODS:From June 1997 to August 2001, the RA graft was used in 271 patients who underwent cardiac surgery at our department....
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2003.43
更新日期:2003-03-01 00:00:00
abstract::Although associated primarily with the cardiovascular system, atrial natriuretic factor (ANF) has been found to increase the magnitude of duodenal contractions and may play a role in salt and water absorption across gastrointestinal epithelium. Because secretory diarrhea and increased peristalsis are commonly associat...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::The release of oxygen radicals, in particular the hydroxyl radical, from sequestered neutrophils produces acute lung injury after a number of insults. Our purpose was to determine whether hydroxyl radical, OH., is responsible for the lung injury from endotoxin characterized by (1) pulmonary leukostasis, (2) increased ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::We have treated 13 patients with limb-threatening ischemia caused by acute arterial thrombosis with selective arterial infusion of streptokinase. The indications for thrombolytic therapy included medical contraindication to surgery, surgically inaccessible thrombi, arterial thrombosis following percutaneous translumin...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:There are few population-based studies addressing the survival after resection for esophageal cancer. This study represents an update of a nationwide Swedish cohort initiated in 1987. METHODS:Based on data from the Swedish Patient Register, Swedish Cancer Register, and histopathologic records, 1,008 patient...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.03.025
更新日期:2012-11-01 00:00:00
abstract::Transplant renal artery stenosis occurred in 17 of 142 consecutive transplants (12 percent). All stenoses were in the renal artery distal to the anastomosis and two separate forms are recognized: angulation and segmental stenosis. Successful surgical correction in 12 of 17 patients relieved the hypertension and result...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:The relationship among bile duct (BD), portal vein (PV), and/or hepatic artery (HA) anatomy is controversial, but no investigation has previously compared left and right liver graft transplantation in terms of variant vasculobiliary anatomy. Therefore, in this study, we explored whether variant BD anatomy ca...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.06.017
更新日期:2010-01-01 00:00:00
abstract::Insulin-glucose homeostasis was examined in 62 patients with chronic pancreatitis (CP). All patients were graded on the basis of test results from five studies: (1) endoscopic retrograde cholangiopancreatography, (2) fat-stimulated release of pancreatic polypeptide (PP), (3) NBT-bentiromide PABA test, (4) 72-hour feca...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::We measured transcutaneous oxygen tension (TcPo2) at a skin temperature of 44 degrees C on 319 limbs in an approximately equal number of nondiabetic and diabetic patients with peripheral vascular disease. Measurements were made above the knee, below the knee (BK), and on the dorsum of the foot. Nondiabetic limbs with ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Ex situ liver surgery allows liver resection and vascular reconstruction in patients who have liver tumors located at critical sites. Only a small series of studies about ex situ liver surgery is available in the literature. No long-term results have been published. METHODS:Twenty-four patients were conside...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.105500
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVES:Outpatient thyroid surgery is becoming increasingly common. The aim of this study was to clarify the principles for safe outpatient thyroid surgery and review our outcomes with the use of a protocol for outpatient thyroidectomy in a large patient cohort. STUDY DESIGN:A systematic analysis of a prospectively...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.08.007
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:This study analyzes trends in hospitalization and outcome for adult, elderly, and pediatric trauma victims in the Florida Trauma System (FTS) from 1991 to 2003, during which time the number of centers nearly doubled from 11 to 20. METHODS:Administrative data was queried for all admissions with at least one ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2006.01.012
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor (TNF) is rapidly gaining recognition as one of the early, critical mediators of several inflammatory conditions, most notably endotoxic shock. The purposes of this study were to determine whether TNF levels are raised in severe acute pancreatitis, thus pointing to its role as a potentia...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Twenty Dacron grafts (10 crimped and 10 noncrimped) were studied with light microscopy, scanning electron microscopy, and transmission electron microscopy (TEM) 1 to 10 months after insertion into the canine thoracoabdominal aorta. Fibroblast-derived pseudointima maintained a smooth luminal lining that approximated th...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Adenosine released by cells during ischemia typically serves as a feedback inhibitor of further organ work. However, in ischemic intestine, adenosine appears to act via stimulatory A2b receptors to increase work in the form of chloride ion (Cl-) secretion. This unusual response may contribute to luminal flui...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80295-9
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to clarify whether the types of portal vein (PV) occlusion during hepatectomy affect the long-term outcome in patients with hepatocellular carcinoma (HCC). METHODS:Eighty-six patients who had undergone curative hepatic resection for HCC were divided on the basis of the type of PV o...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.02.008
更新日期:2005-06-01 00:00:00