当前位置： SCI文献检索 > SURGERY期刊下所有文献 > Pretransplant malignancy among lung transplant recipients in the modern era.

Pretransplant malignancy among lung transplant recipients in the modern era.

Abstract：

BACKGROUND:Malignancy is a relative contraindication in transplant candidates, given the increased neoplastic risk accompanying posttransplant immunosuppression. However, the number of patients receiving a lung transplant despite pretransplant malignancy is rising, and their outcomes remain unclear. Our purpose was to examine the outcomes of lung transplant recipients with pretransplant malignancy in the modern era. METHODS:We evaluated the United Network for Organ Sharing registry for adult lung transplants that were completed between June 2005 and September 2016. Transplant recipients were stratified by pretransplant malignancy, with subgroup analysis by sex and active malignancy. The primary outcome was 5-year survival and the secondary outcome was cause of death. Kaplan-Meier estimates illustrated 5-year survival and multivariable Cox proportional hazards regressions controlled for demographics and comorbidities. RESULTS:Of 18,032 transplant patients, 1,321 transplant recipients (7.3%) possessed a pretransplant malignancy. Patients with pretransplant malignancy faced significantly greater mortality within 5 years (36.0% vs 32.8%, P = .017), an effect greatest in men with pretransplant malignancy (39.2% vs 33.7%, P = .002). Patients with pretransplant malignancy also faced greater risk of death from posttransplant malignancy (15.6% vs 9.4%, P < .001), particularly for those with active malignancy at transplant (34.8% vs 9.8%, P < .001). Pretransplant malignancy remained a significant predictor of 5-year mortality in adjusted Cox regressions (hazard ratio: 1.16 [1.05-1.27], P = .003). CONCLUSION:Patients with pretransplant malignancy, and particularly men with pretransplant malignancy and those with active malignancy at transplant, are at an increased risk of 5-year mortality and posttransplant death from malignancy. Balancing individual risk of posttransplant malignancy with immunosuppressive care is necessary to optimize outcomes for pretransplant malignancy patients.

journal_name

Surgery

journal_title

Surgery

authors

Rudasill SE,Iyengar A,Sanaiha Y,Khoury H,Mardock AL,Xing H,Kwon MH,Hunter C,Benharash P

doi

10.1016/j.surg.2019.01.008

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1228-1233

issue

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(19)30039-X

journal_volume

165

pub_type

杂志文章

在线工具

Pretransplant malignancy among lung transplant recipients in the modern era.