Abstract:
BACKGROUND:The current study was designed to determine the effects of antibody blockade of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) on the proinflammatory activity of mesenteric lymph after hemorrhagic shock and resuscitation (HS/R). METHODS:Rats were subjected to HS/R with or without treatment with MAdCAM-1 polyclonal antibody. MAdCAM-1 expression and lymphocyte infiltration in rats were examined. Post-shock mesenteric lymph was collected, filtered to remove lymphocytes, and transfused into recipient mice to induce systemic inflammation and intestinal injury. The proinflammatory activity of post-shock lymph in mice was determined by examining intestinal permeability, enterocyte apoptosis, intestinal lactate levels, lung myeloperoxidase (MPO) activity, and serum cytokine levels. Survival of recipient mice was determined over a 1-week time period. RESULTS:Rats subjected to HS/R had increased MAdCAM-1 expression and lymphocyte infiltration in the intestine. Antibody blockade of MAdCAM-1 attenuated the increased lymphocyte infiltration after HS/R (P < .05). Post-shock mesenteric lymph transfusion significantly increased mortality accompanied by increases in gut permeability, enterocyte apoptosis, intestinal lactate levels, lung MPO activity, and serum levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, IL-10, and transforming growth factor-β (all P < .05). Antibody blockade of MAdCAM-1 in rats subjected to HS/R attenuated the proinflammatory activity of post-shock mesenteric lymph, with abrogation of lymph transfusion-induced increases in mortality, gut permeability, epithelial cell apoptosis, intestinal lactate levels, lung MPO activity, and serum levels of IL-1β, IL-6, and TNF-α (all P < .05). CONCLUSION:These findings demonstrate that antibody blockade of MAdCAM-1 attenuates the proinflammatory activity of mesenteric lymph after HS/R.
journal_name
Surgeryjournal_title
Surgeryauthors
Zhang HY,Besner GE,Feng JXdoi
10.1016/j.surg.2015.12.013subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1449-60issue
5eissn
0039-6060issn
1532-7361pii
S0039-6060(15)01051-Xjournal_volume
159pub_type
杂志文章相关文献
SURGERY文献大全abstract::We studied 28 patients who had undergone 30 operations for pheochromocytoma since 1964. The tumor types included bilateral, extra-adrenal, malignant, recurrent, and multiple endocrine neoplasia, with 20 tumors confined to the adrenal gland. The preoperative studies used to localize the tumor included ultrasonography, ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Colonoscopy has had a major impact on the incidence and survival of colon cancer for patients who are screened, usually beginning at the age of 50. Meanwhile, the incidence rate of colon cancer is actually increasing in the patients younger than 50 while no routine screening is implemented for this age group...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.07.018
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Lung contusion (LC) is a unique direct and focal insult that is considered a major risk factor for the initiation of acute lung injury and acute respiratory distress syndrome. We have shown recently that consumption of nitric oxide (due to excess superoxide) resulting in peroxynitrite formation leads to decr...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.05.023
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:After portal vein ligation of 1 side of the liver, the other side regenerates at a slow rate. This slow growth may be accelerated to rapid growth by adding a transection between the 2 sides, i.e., performing portal vein ligation and parenchymal transection. We found that in patients undergoing portal vein li...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.05.018
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Studies of risk factors after pancreatoduodenectomy are few: some concern restricted populations and others are based on administrative data. METHODS:Multicenter clinical data were collected for 300 patients undergoing pancreatoduodenectomy to determine (by univariate and multivariate analysis) preoperative...
journal_title:Surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.surg.2005.08.012
更新日期:2006-05-01 00:00:00
abstract::An evaluation of double isotope subtraction scanning with 201Tl and 99mTc was performed in 14 patients with primary hyperparathyroidism. Twelve of 13 adenomas and seven of seven hyperplastic glands were localized correctly by preoperative scanning. The technique appears useful for the identification of abnormal parath...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Thromboprophylaxis aims to reduce venous thromboembolism but has the potential to increase bleeding. We sought to evaluate the risk of venous thromboembolism and transfusion after major abdominopelvic procedures and to quantify the association of the procedure with venous thromboembolism. METHODS:The Americ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.05.050
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Statewide trauma systems are implemented by health care policy makers whose intent is to improve the process of care delivered to seriously injured patients. In Oregon, Advanced Trauma Life Support (ATLS) training was mandated for all physicians employed in the emergency department of trauma centers. The pur...
journal_title:Surgery
pub_type: 杂志文章,多中心研究
doi:10.1067/msy.2001.115898
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:The goal of this study was to determine, in lung transplant patients, if laparoscopic antireflux surgery (LARS) is an effective means to prevent aspiration as defined by the presence of pepsin in the bronchoalveolar lavage fluid (BALF). METHODS:Between September 2009 and November 2010, we collected BALF fro...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.07.053
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Several studies have reported that the triangulating stapling method decreases the incidence of anastomotic stricture after esophagectomy, but no randomized, controlled trial has confirmed the efficacy of the triangulating stapling method for cervical esophagogastrostomy. We compared triangulating stapling a...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.01.013
更新日期:2017-07-01 00:00:00
abstract::To assess the role of portal hemodynamics in the development of postshunt encephalopathy, we studied 19 patients after small-diameter portacaval H grafting (SD-PCHG). We used contrast studies as well as technetium-labeled macroaggregated albumin injected into the portal vein to assess direction of portal flow. We then...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract::The optimal stimulus which produced the maximum increase in blood velocity in the femoral vein during compression of the lower limb with a sequential compression device (six chambers) was determined using Doppler ultrasound in 10 normal limbs. Pressures of 35, 30, and 20 mm Hg at the ankle, calf, and thigh, respective...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:In sepsis red blood cells (RBCs) have been shown to be less deformable (i.e., more rigid) and have been implicated in decreasing nutrient blood supply and possibly leading to organ dysfunction. However, no studies have demonstrated an association between organ dysfunction and rigid RBCs. This study examined ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::A case of celiac trunk aneurysm treated by excision and direct reanastomosis with restoration of arterial continuity, and a description of a new technique for selective visualization of the celiac artery are reported. A review of the literature with tabulation of all surgically treated cases is included. Significance ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract::The intestinal phase of gastric acid secretion is mediated by the putative hormone entero-oxyntin. The release of the hormone has been demonstrated in both dog and rat models during an intestinal meal of liver extract. The maximal gastric acid response to pentagastrin is augmented by the presence of liver extract in t...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::The influence of cimetidine on blood flow to the gastric corpus and antrum of the dog was studied using the double isotope microsphere distribution technique. This H2 receptor antagonist caused no changes in blood flow to any portion of the stomach nor did it alter systemic circulatory parameters. The therapeutic effe...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Polymorphonuclear neutrophil (PMN) sequestration in the lung is a hallmark of acute respiratory distress syndrome (ARDS). We have shown that 25% Albumin (A25) resuscitation attenuates lung injury after hemorrhagic shock and lipopolysaccharide (LPS) exposure by reducing lung leukosequestration. We hypothesize...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2002.126508
更新日期:2002-08-01 00:00:00
abstract::Infusion phlebitis is the most common complication of intravenous therapy. Six methods of reducing the incidence of infusion phlebitis including inline final filtration, buffers, heparin, hydrocortisone, heparin-hydrocortisone combinations, and frequent set changes were tested in a two part randomized prospective doub...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1979-04-01 00:00:00
abstract::In this study we investigated the effect of splenectomy in combination with cyclosporine (CsA) on survival of heterotopic cardiac xenografts from hamster to rat. A 12-fold prolongation of mean cardiac xenograft survival, to 41 days, was accomplished with the combined therapy. In both untreated controls and CsA-treated...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Alternative methods for abdominal wall closure may be necessary after emergency laparotomy. The purpose of this study was to determine the morbidity and outcome of emergency fascial closure with polypropylene mesh. METHODS:A retrospective review was performed of all patients undergoing emergency fascial clo...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:10.1016/s0039-6060(05)80043-1
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Peptide receptor radionuclide therapy is a valid therapeutic option for pancreatic neuroendocrine neoplasms. The aim of this study was to describe an initial experience with the use of peptide receptor radionuclide therapy as a neoadjuvant agent for resectable or potentially resectable pancreatic neuroendocr...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.11.007
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to clarify the still poorly understood dynamics of peritoneal inflammatory cells (PICs) in acute pancreatitis. METHODS:Acute pancreatitis of 3 different degrees of severity was induced in male Wistar rats. Peritoneal lavage was performed at 1, 6, 12, and 24 hours after the indu...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2002.125171
更新日期:2002-07-01 00:00:00
abstract::Serial determinations of human thymus-dependent (T) and bone marrow-dependent (B) peripheral blood lymphocytes were performed to detect changes in activity of these rosette-forming cells in five groups of patients: controls; chronic renal failure (CRF) patients; dialysis patients receiving pretransplant splenectomy; 5...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract:BACKGROUND:After sphincter-saving operation for rectal cancer, the impact of anastomotic leakage on function has been well studied. The purpose of the present work was to assess the influence of symptomatic and asymptomatic anastomotic leakage on bowel function and health-related quality of life using the Low Anterior ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.09.037
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Laparoscopic Nissen fundoplication (LNF) is gaining popularity. Although the hemodynamic effects of the typical pneumoperitoneum have been studied, the additional consequences of the hiatal dissection necessary for LNF have not. METHODS:Seven female pigs were anesthetized, intubated, and ventilated with a v...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90026-x
更新日期:1997-08-01 00:00:00
abstract::John Syng Dorsey is one of the unsung heroes of American surgery. In 1811 he performed this country's first successful ligation of the external iliac artery, for a massive aneurysm in the right groin. Two years later he wrote America's first systematic textbook of surgery. In addition, he held the professorial chairs ...
journal_title:Surgery
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Little is known about the clinical significance and risk factors for incomplete liver restoration after partial hepatectomy, which is defined by a liver volume restoration of less than 100% of the original volume. METHODS:We retrospectively analyzed patients who underwent hepatic resection for liver tumors ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.02.022
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:In a dynamic health care system, strong leadership has never been more important for surgeons. Little is known about how to design and conduct effectively a leadership program specifically for surgeons. We sought to evaluate critically a Leadership Development Program for practicing surgeons by exploring how...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.03.011
更新日期:2016-08-01 00:00:00
abstract::The term big data has been popularized over the past decade and is often used to refer to data sets that are too large or complex to be analyzed by traditional means. Although the term has been utilized for some time in business and engineering, the concept of big data is relatively new to medicine. The reception from...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.06.022
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Pelvic ring fractures (PRFs) are a major cause of morbidity and mortality in motor vehicle collisions (MVCs). Understanding the factors leading to PRFs may help improve vehicle design and safety. This study sought to determine the vehicular, crash, and occupant characteristics that contribute to PRFs. METHO...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.07.003
更新日期:2004-10-01 00:00:00