Hypoxia of the growing liver accelerates regeneration.

Abstract:

BACKGROUND:After portal vein ligation of 1 side of the liver, the other side regenerates at a slow rate. This slow growth may be accelerated to rapid growth by adding a transection between the 2 sides, i.e., performing portal vein ligation and parenchymal transection. We found that in patients undergoing portal vein ligation and parenchymal transection, portal vein hyperflow in the regenerating liver causes a significant reduction of arterial flow due to the hepatic arterial buffer response. We postulated that the reduction of arterial flow induces hypoxia in the regenerating liver and used a rat model to assess hypoxia and its impact on kinetic growth. METHODS:A rat model of rapid (portal vein ligation and parenchymal transection) and slow regeneration (portal vein ligation) was established. Portal vein flow and pressure data were collected. Liver regeneration was assessed in rats using computed tomography, proliferation with Ki-67, and hypoxia with pimonidazole and HIF-1α staining. RESULTS:The rat model confirmed acceleration of regeneration in portal vein ligation and parenchymal transection as well as the portal vein hyperflow seen in patients. Additionally, tissue hypoxia was observed after portal vein ligation and parenchymal transection, while little hypoxia staining was detected after portal vein ligation. To determine if hypoxia is a consequence or an inciting stimulus of rapid liver regeneration, we used a prolyl-hydroxylase blocker to activate hypoxia signaling pathways in the slow model. This clearly accelerated slow to rapid liver regeneration. Inversely, abrogation of hypoxia led to a blunting of rapid growth to slow growth. The topical application of prolyl-hydroxylase inhibitors on livers in rats induced spontaneous areas of regeneration. CONCLUSION:This study shows that pharmacologically induced hypoxic signaling accelerates liver regeneration similar to portal vein ligation and parenchymal transection. Hypoxia is likely an accelerator of liver regeneration. Also, prolyl-hydroxylase inhibitors may be used to enhance liver regeneration pharmaceutically.

journal_name

Surgery

journal_title

Surgery

authors

Schadde E,Tsatsaris C,Swiderska-Syn M,Breitenstein S,Urner M,Schimmer R,Booy C,Z'graggen BR,Wenger RH,Spahn DR,Hertl M,Knechtle S,Diehl AM,Schläpfer M,Beck-Schimmer B

doi

10.1016/j.surg.2016.05.018

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

666-679

issue

3

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(16)30192-1

journal_volume

161

pub_type

杂志文章

相关文献

SURGERY文献大全
  • Consequences of preoperative cholangitis and its treatment on the outcome of operation for choledocholithiasis.

    abstract::During a 30-month period 73 patients underwent operation for choledocholithiasis. Thirty-three of these patients (45%) had cholangitis preoperatively. When compared to patients with common duct stones who had no preoperative cholangitis, patients with cholangitis were older (P less than 0.001), more likely to present ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Pitt HA,Postier RG,Cameron JL

    更新日期:1983-09-01 00:00:00

  • NIFT-P: Are they indolent tumors? Results of a multi-institutional study.

    abstract:BACKGROUND:Encapsulated follicular variant of papillary thyroid carcinoma has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the basis of its highly indolent behavior, as proposed by an international group of experienced thyroid pathologists. METHODS:All p...

    journal_title:Surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.surg.2018.04.089

    authors: Chereau N,Greilsamer T,Mirallié E,Sadowski SM,Pusztaszeri M,Triponez F,Baud G,Pattou F,Christou N,Mathonnet M,Brunaud L,Santucci N,Goudet P,Guérin C,Sebag F,Donatini G,Kraimps JL,Tissier F,Lussey-Lepoutre C,Leenhard

    更新日期:2019-01-01 00:00:00

  • Physicians and the Navy Cross: a treatise on courage.

    abstract::Heroism among military physicians has been heralded throughout our history. Four Navy trauma surgeons who received the Navy Cross for extraordinary service during the Vietnam War were studied with reference to their early lives, the events leading to the act for which they received the Navy Cross, and their later live...

    journal_title:Surgery

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Mavroudis C

    更新日期:1991-11-01 00:00:00

  • Calorie-nitrogen interactions in the parenterally fed primate.

    abstract::To test the hypothesis that nonprotein calorie intake and nitrogen intake are equally important in establishing positive nitrogen balance, weight gain, and serum protein response in the depleted primate treated with total parenteral nutrition (TPN), 10 adult male chair-adapted primates (Macaque fascicularis) were stud...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Dempsey DT,Mullen JL,Crosby LO,Hurwitz S

    更新日期:1988-01-01 00:00:00

  • Evolution of the surgical approach for replacement of degenerated mitral bioprostheses.

    abstract:BACKGROUND:Primary tissue failure is the most frequent indication for reoperation in patients with a mitral bioprosthetic valve (MBPV). Complete excision of the bioprosthesis is time-consuming and may be complicated by cardiac rupture at the atrioventricular junction or the posterior left ventricular wall where a strut...

    journal_title:Surgery

    pub_type: 杂志文章,评审

    doi:10.1016/s0039-6060(05)80033-9

    authors: Geha AS,Lee JH

    更新日期:1995-10-01 00:00:00

  • The "July phenomenon" and the care of the severely injured patient: fact or fiction?

    abstract:BACKGROUND:The "July phenomenon," a common belief in medical academia, refers to purported errors, inefficiency, and negative outcomes during the summertime transition of the house staff. We hypothesized that care in a trauma service is consistent throughout the year and that the July phenomenon therefore is a myth. M...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2001.116670

    authors: Claridge JA,Schulman AM,Sawyer RG,Ghezel-Ayagh A,Young JS

    更新日期:2001-08-01 00:00:00

  • Horseshoe anomaly of the appendix: a previously undescribed entity.

    abstract::Anomalies of the appendix are extremely rare. The case presented here has not been previously described and is that of a "horseshoe" appendix in a 33-year-old man with sigmoid diverticulitis. This appendiceal variant cannot be classified into any of the existing categories of appendiceal anomalies. ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Mesko TW,Lugo R,Breitholtz T

    更新日期:1989-09-01 00:00:00

  • Natural history of nonenhancing lesions incidentally detected during the diagnosis of hepatocellular carcinoma.

    abstract:BACKGROUND:Incidental detection of nonenhancing tumors during imaging studies for patients with classical hepatocellular carcinoma is not unusual. These tumors are considered to have a high potential of malignant transformation. The aim of this study was to clarify the natural history of such tumors. METHODS:In 93 pat...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2016.04.019

    authors: Ebisawa K,Midorikawa Y,Higaki T,Nakayama H,Tsuji S,Nishimaki H,Haradome H,Abe O,Sugitani M,Moriyama M,Takayama T

    更新日期:2016-09-01 00:00:00

  • Vascular and stimulation delays in dynamic musculoplasty.

    abstract:BACKGROUND:Dynamic musculoplasty is increasingly being used to replace severely damaged muscle. Electrical stimulation induces a change in muscle composition from type II to type I muscle fibers. The aim of this study was to assess the optimal time to start stimulation and the beneficial effect of a vascular delay. ME...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/s0039-6060(97)90310-x

    authors: Geerdes BP,Heineman E,Freling G,Keizer HA,Woloszko J,Baeten CG

    更新日期:1997-04-01 00:00:00

  • Use of omeprazole in the management of giant duodenal ulcer: results of a prospective study.

    abstract:BACKGROUND:Giant duodenal ulcer (GDU) is generally thought to require surgical intervention. Proton pump inhibitors have beneficial effects in peptic ulcer disease, but their role in GDU disease is unknown. We examined the use of omeprazole in GDU management. METHODS:Twenty-eight patients were diagnosed with GDU. One ...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章

    doi:

    authors: Fischer DR,Nussbaum MS,Pritts TA,Gilinsky NH,Weesner RE,Martin SP,Giannella RA

    更新日期:1999-10-01 00:00:00

  • The effect of depression on stage at diagnosis, treatment, and survival in pancreatic adenocarcinoma.

    abstract:BACKGROUND:Depression has been associated with delayed presentation, inadequate treatment, and poor survival in patients with cancer. METHODS:Using Surveillance, Epidemiology and End Results and Medicare linked data (1992-2005), we identified patients with pancreatic adenocarcinoma (N = 23,745). International classifi...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2012.06.010

    authors: Boyd CA,Benarroch-Gampel J,Sheffield KM,Han Y,Kuo YF,Riall TS

    更新日期:2012-09-01 00:00:00

  • Is a diverting ostomy needed in mid-high rectal cancer patients undergoing a low anterior resection after neoadjuvant chemoradiation? An NSQIP analysis.

    abstract:INTRODUCTION:A diverting stoma is often performed at the time of low anterior resection (LAR) for rectal cancer after neoadjuvant chemoradiation (nCRT) to protect the anastomosis. The aim of this study was to compare surgical outcomes in large cohorts of mid-high rectal cancer patients undergoing LAR after nCRT with an...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2015.02.026

    authors: Messaris E,Connelly TM,Kulaylat AN,Miller J,Gusani NJ,Ortenzi G,Wong J,Bhayani N

    更新日期:2015-09-01 00:00:00

  • Metastatic potential of metastases.

    abstract::Nine cases of known metastases originating from other metastatic foci were documented at operation. The primary tumors included four melanomas, two osteosarcomas, a synovial sarcoma, an anaplastic lung carcinoma, and a rhadbomyosarcoma. Secondary metastatic sites to the regional lymph nodes were noted in the pulmonary...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Roth JA,Silverstein MJ,Morton DL

    更新日期:1976-06-01 00:00:00

  • Gastrin-dependent inhibitory effects of octreotide on the genesis of gastric ECLomas.

    abstract:BACKGROUND:The efficacy of octreotide in the regulation of endocrine tumor secretion and symptomatology has been well documented. Its effects on neuroendocrine tumor generation and cell proliferation are less well understood. The purpose of this study was to determine if blockade of somatostatin receptors by octreotide...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Modlin IM,Kumar R,Nangia A,Soroka CJ,Pasikhov D,Goldenring JR

    更新日期:1992-12-01 00:00:00

  • Enhancement of rat renal allografts with monoclonal antibody.

    abstract::Treatment of rat allograft recipients before grafting with donor spleen cells and whole, pooled antidonor alloimmune serum results in indefinite renal allograft survival. The enhancement is immunologically specific. In these experiments a monoclonal, homogenous anti-BN antibody was produced by a hybridoma clone create...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Stuart FP,McKearn TJ,Fitch FW

    更新日期:1979-07-01 00:00:00

  • Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.

    abstract:BACKGROUND:Sphingosine-1-phosphate, a pleiotropic bioactive lipid mediator, is an important player in cancer progression. Previous studies suggested that sphingosine-1-phosphate produced by sphingosine kinase 1, which is activated by phosphorylation, plays important roles in the progression of disease and metastasis. T...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2017.11.024

    authors: Hanyu T,Nagahashi M,Ichikawa H,Ishikawa T,Kobayashi T,Wakai T

    更新日期:2018-06-01 00:00:00

  • Pheochromocytoma as the first manifestation of von Hippel-Lindau disease.

    abstract:BACKGROUND:von Hippel-Lindau disease is an autosomal dominant disorder characterized by the development of hemangioblastomas in the cerebellum, spinal cord, and retina, renal cell carcinoma and cysts, pancreatic cysts, and pheochromocytoma. METHODS:We have studied a series of 36 French patients affected with von Hippe...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Richard S,Beigelman C,Duclos JM,Fendler JP,Plauchu H,Plouin PF,Resche F,Schlumberger M,Vermesse B,Proye C

    更新日期:1994-12-01 00:00:00

  • Endothelin receptor blockade in severe acute pancreatitis leads to systemic enhancement of microcirculation, stabilization of capillary permeability, and improved survival rates.

    abstract:BACKGROUND:We previously demonstrated that therapy with a new endothelin A receptor antagonist (ET-RA) significantly reduced mortality rates in severe acute pancreatitis (AP) in the rat without attenuating local signs of disease severity (intrapancreatic protease activation, acinar cell necrosis). This raised the quest...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2000.107104

    authors: Foitzik T,Eibl G,Hotz HG,Faulhaber J,Kirchengast M,Buhr HJ

    更新日期:2000-09-01 00:00:00

  • The quality of surgical clerkships.

    abstract::Many of the contours of a surgical clerkship can be designed, implemented, and evaluated with varying degrees of objectivity. The recently established Association for Surgical Education and its expanding membership have performed in an excellent fashion in addressing the objectives, content, process, and evaluation of...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Holden WD

    更新日期:1985-06-01 00:00:00

  • Patient perspectives on postoperative visits after common general operative procedures.

    abstract:BACKGROUND:Many postoperative concerns after common general operative procedures may be addressed over the phone, thereby saving time and resources for both the patient and surgeon. METHODS:Over a 6-month time period, patients who underwent laparoscopic cholecystectomy, appendectomy for uncomplicated appendicitis, and...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2013.05.005

    authors: Wright GP,Wolf AM,Ambrosi G,Dull MB,Chung MH

    更新日期:2013-10-01 00:00:00

  • Significance of the in-training examination in a surgical residency program.

    abstract::The exact role that the American Board of Surgery In-Training Examination plays in resident evaluation remains poorly defined. We have required that all residents take the In-Training Examination annually. An analysis was performed of the results of the In-Training Examination and the Qualifying Examination of the Ame...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Garvin PJ,Kaminski DL

    更新日期:1984-07-01 00:00:00

  • Aspiration pneumonia: beneficial and harmful effects of positive end-expiratory pressure.

    abstract::With an ex vivo, isolated, ventilated, perfused canine pulmonary lobe, the effects of various levels of positive end-expiratory pressure (PEEP) were evaluated following acid injury. Following intrabronchial instillation of hydrochloric acid, eight lobes were ventilated with 5 cm of H2O of PEEP, 12 lobes with 10 cm of ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Toung T,Saharia P,Permutt S,Zuidema GD,Cameron JL

    更新日期:1977-08-01 00:00:00

  • Follicular carcinoma of the thyroid gland: trends and treatment.

    abstract::Pure follicular carcinoma of the thyroid gland has become a relatively uncommon type of primary thyroid neoplasm in the United States. During a 20-year period (1962 to 1982) 37 cases of pure follicular carcinoma were treated at the University of Michigan Medical Center. Cases of the follicular variant of papillary car...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Harness JK,Thompson NW,McLeod MK,Eckhauser FE,Lloyd RV

    更新日期:1984-12-01 00:00:00

  • Growth hormone together with glutamine-containing total parenteral nutrition maintains muscle glutamine levels and results in a less negative nitrogen balance after surgical trauma.

    abstract:BACKGROUND:Muscle protein catabolism, reflected by a decrease in glutamine (GLN), a decrease in muscle protein synthesis, and a negative nitrogen balance can be reduced by either administration of GLN or growth hormone (GH). In this study, the effects of a combination of GH and GLH were studied. METHODS:Patients (n = ...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/msy.2001.112593

    authors: Hammarqvist F,Sandgren A,Andersson K,Essén P,McNurlan MA,Garlick PJ,Wernerman J

    更新日期:2001-05-01 00:00:00

  • Regression of intimal hyperplasia with restoration of endothelium-dependent relaxing factor-mediated relaxation in experimental vein grafts.

    abstract:BACKGROUND:The reversibility of the morphologic and functional alterations that occur in veins transplanted into the arterial circulation was examined in this study. METHODS:Common carotid vein bypass grafts (VG) were performed in 20 male New Zealand White rabbits. Ten VG and jugular veins (CV) were harvested after 14...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Davies MG,Klyachkin ML,Dalen H,Svendsen E,Hagen PO

    更新日期:1993-08-01 00:00:00

  • Polyadenylic-polyuridylic acid enhances the natural cell-mediated cytotoxicity in patients with breast cancer undergoing mastectomy.

    abstract:BACKGROUND:Surgical procedures suppress host antitumor defense mechanisms, which may increase the risk of metastatic tumor dissemination. We have evaluated the effects of the biologic response modifier polyadenylic-polyuridylic acid (PAPU) on natural cytotoxicity in patients with breast cancer undergoing operation. ME...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0039-6060(05)80370-8

    authors: Khan AL,Richardson S,Drew J,Larsen F,Campbell M,Heys SD,Ah-See AK,Eremin O

    更新日期:1995-09-01 00:00:00

  • Escalation of care and failure to rescue: a multicenter, multiprofessional qualitative study.

    abstract:BACKGROUND:The escalation of care process has not been explored in surgery, despite the role of communication failures in adverse events. This study aimed to develop a conceptual framework of the influences on escalation of care in surgery allowing solutions to facilitate management of sick patients to be developed. M...

    journal_title:Surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.surg.2014.01.016

    authors: Johnston M,Arora S,King D,Stroman L,Darzi A

    更新日期:2014-06-01 00:00:00

  • Laparoscopic distal pancreatectomy employing radical en bloc procedure for adenocarcinoma: Technical details and outcomes.

    abstract:BACKGROUND:Although laparoscopic distal pancreatectomy (LDP) has increasingly gained popularity, there are only a few reports mentioning application and outcomes of LDP for adenocarcinoma of the body and tail of the pancreas. The aim of our study is to demonstrate technical details of LDP employing radical en bloc proc...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2014.12.015

    authors: Kawaguchi Y,Fuks D,Nomi T,Levard H,Gayet B

    更新日期:2015-06-01 00:00:00

  • Neuroendocrine tumors of the pancreas: Degree of cystic component predicts prognosis.

    abstract:BACKGROUND:Although most pancreatic neuroendocrine tumors are solid, approximately 10% are cystic. Some studies have suggested that cystic pancreatic neuroendocrine tumors are associated with a more favorable prognosis. METHODS:A retrospective review of all patients with pancreatic neuroendocrine tumors who underwent ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2016.04.005

    authors: Cloyd JM,Kopecky KE,Norton JA,Kunz PL,Fisher GA,Visser BC,Dua MM,Park WG,Poultsides GA

    更新日期:2016-09-01 00:00:00

  • Central venous dialysis access: experience with a dual-lumen, silicone rubber catheter.

    abstract::The central venous dialysis catheter has gained wide acceptance for short-term hemodialysis with the realization of the need to spare peripheral extremity vessels for the creation of more durable internal arteriovenous fistulas. The Hemocath (Quinton Instrument Co., Seattle, Wash.), a soft, silicone rubber, double-lum...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Dunn J,Nylander W,Richie R

    更新日期:1987-11-01 00:00:00