当前位置： SCI文献检索 > SURGERY期刊下所有文献 > NIFT-P: Are they indolent tumors? Results of a multi-institutional study.

NIFT-P: Are they indolent tumors? Results of a multi-institutional study.

Abstract：

BACKGROUND:Encapsulated follicular variant of papillary thyroid carcinoma has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the basis of its highly indolent behavior, as proposed by an international group of experienced thyroid pathologists. METHODS:All patients from 9 high-volume endocrine surgery departments who underwent surgery between 2005 and 2015 and whose final surgical pathology revealed noninvasive follicular thyroid neoplasm with papillary-like nuclear features (>10 mm) were included in this study. The primary outcome was to determine the potential for recurrent disease in these patients. RESULTS:Among the 363 patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features, 76% were female with a median age of 50 years (5-86 years); 345 patients (95%) underwent total thyroidectomy. A total of 65 patients had an associated micropapillary thyroid carcinoma. In the group of 133 patients who underwent prophylactic lymph node dissection (37%), 1 patient had a micrometastasis but with an associated micropapillary thyroid carcinoma. Over a median follow-up period of 5 years, 1 patient with an associated micropapillary thyroid carcinoma had recurrent disease at 6 years. All patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features without micropapillary thyroid carcinoma had no lymph node metastasis or recurrent disease. CONCLUSION:We found that noninvasive follicular thyroid neoplasm with papillary-like nuclear features presents with indolent behavior. However, the identification of an associated micropapillary thyroid carcinoma should be carefully evaluated because it could be a factor for lymph node metastasis and/or of recurrence.

journal_name

Surgery

journal_title

Surgery

authors

Chereau N,Greilsamer T,Mirallié E,Sadowski SM,Pusztaszeri M,Triponez F,Baud G,Pattou F,Christou N,Mathonnet M,Brunaud L,Santucci N,Goudet P,Guérin C,Sebag F,Donatini G,Kraimps JL,Tissier F,Lussey-Lepoutre C,Leenhard

doi

10.1016/j.surg.2018.04.089

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

12-16

issue

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(18)30624-X

journal_volume

165

pub_type

杂志文章,多中心研究

在线工具

NIFT-P: Are they indolent tumors? Results of a multi-institutional study.