Abstract：
:Treatment of rat allograft recipients before grafting with donor spleen cells and whole, pooled antidonor alloimmune serum results in indefinite renal allograft survival. The enhancement is immunologically specific. In these experiments a monoclonal, homogenous anti-BN antibody was produced by a hybridoma clone created by fusing the mouse-P3 myeloma with spleen cells from Lewis rats immunized with BN lymphoid cells. The hybridoma supernatent enhanced survival of LBN renal allografts in Lewis recipients as effectively as whole Lewis anti-BN antiserum. Dilution of the hybridoma supernatent by tenfold or a hundredfold abrogated the enhancement effect.
journal_name
Surgeryjournal_title
Surgeryauthors
Stuart FP,McKearn TJ,Fitch FWsubject
Has Abstractpub_date
1979-07-01 00:00:00pages
30-5issue
1eissn
0039-6060issn
1532-7361pii
0039-6060(79)90126-0journal_volume
86pub_type
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