Abstract：
:Solid tumors constantly require a vascular supply for their progression and metastasis. Hepatocellular carcinoma (HCC) is known to gain its hypervascularity during the process of dedifferentiation and progression. Various angiogenic growth factors and inhibitors regulate this angiogenic switch of HCC. The known endothelial cell-specific growth factors and their receptors can be classified into the vascular endothelial growth factor and angiopoietin families. Both vascular endothelial growth factors and angiopoietins have been found to work cooperatively, and both are essential for HCC angiogenesis. Because small and ill-vascularized HCCs slowly progress and only rarely metastasize, antiangiogenic therapy could therefore be a promising anticancer strategy for HCC.
journal_name
Surgeryjournal_title
Surgeryauthors
Sugimachi K,Tanaka S,Terashi T,Taguchi K,Rikimaru T,Sugimachi Kdoi
10.1067/msy.2002.119365subject
Has Abstractpub_date
2002-01-01 00:00:00pages
S135-41issue
1 Suppleissn
0039-6060issn
1532-7361pii
S0039-6060(02)08518-5journal_volume
131pub_type
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