Abstract：
BACKGROUND:Liver resection is the only curative treatment offering a chance of long-term survival in patients with colorectal liver metastases (CRM). Recent data indicated that liver resection in patients with tumor progression while receiving chemotherapy was associated with poor outcome. The aim of the study was to identify risk factors for poor outcome in patients with pre-operative chemotherapy of CRM. METHODS:We analyzed 160 patients after liver resection for CRM with preoperative systemic. chemotherapy. Three groups of patients were identified: 44 patients (27.5%) had a tumor response, 20 (12.5%) showed stable disease, and 96 (60%) patients had tumor progression while on chemotherapy. Median follow-up was 2.4 years (range, 6 days-11.1 years). All available clinicopathologic variables possibly associated with outcome were evaluated. RESULTS:Survival was 88%, 53%, and 37% at 1, 3, and 5 years. Noncurative resection, carcinoembryonic antigen levels >200 ng/ml, tumor grading, size of the largest tumor >5 cm, and number of metastases were associated with poor patient outcome. In the multivariate analysis, tumor free margin and tumor grading correlated with the outcome. Tumor progression while on chemotherapy had no influence on the long-term survival. CONCLUSION:Liver resection offers a long-term survival benefit for patients with CRM, even when tumor growth proceeds during pre-operative chemotherapy.
journal_name
Surgeryjournal_title
Surgeryauthors
Neumann UP,Thelen A,Röcken C,Seehofer D,Bahra M,Riess H,Jonas S,Schmeding M,Pratschke J,Bova R,Neuhaus Pdoi
10.1016/j.surg.2009.02.004subject
Has Abstractpub_date
2009-07-01 00:00:00pages
52-9issue
1eissn
0039-6060issn
1532-7361pii
S0039-6060(09)00102-0journal_volume
146pub_type
杂志文章相关文献
SURGERY文献大全abstract：:In this study a smooth muscle cell seeding technique was developed and evaluated in biodegradable vascular grafts in rats. Cultured smooth muscle cells (3.5 to 5 X 10(6) in 0.1 ml whole blood) were seeded by means of a one-step preclotting technique in microporous, compliant, biodegradable vascular grafts (internal di...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:A case of transient cerebral and retinal ischemia caused by giant cell arteritis is reported. Because of the distribution of the disease, the patient was treated with a subclavian to carotid reversed saphenous vein graft. The clinical features of giant cell arteritis affecting the branches of the aortic arch are revie...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：BACKGROUND:With tighter constraints on health care spending, many recognize the need to identify and restrict clinical interventions that are not cost-effective. As a result, cost-effectiveness analysis is being used increasingly to assess the relative value of surgical interventions. METHODS AND RESULTS:We first pres...
journal_title：Surgery
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-01 00:00:00
abstract：:We identified 106 patients who had undergone complete resection of isolated colorectal hepatic metastases. Nine of these patients subsequently underwent repeat liver resections for isolated hepatic recurrences. The median follow-up for these patients was 21 months. One postoperative death was related to the second hep...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Although task training on virtual reality (VR) simulators has been shown to transfer to the operating room, to date no VR curricula have been described for advanced laparoscopic procedures. The purpose of this study was to develop a proficiency-based VR technical skills curriculum for laparoscopic colorectal...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.08.005
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:This study examines factors associated with the performance of orthotopic liver transplantation (OLT) without red blood cell (RBC) transfusion. METHODS:Between January 1992 and December 1994, 306 primary OLTs were performed with recipients divided into two groups: group 1 patients (61 recipients, 20% of tot...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80019-5
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:Up to 70% of children with small bowel transplantation (SBTx) experience acute cellular rejection (ACR). Allospecific CD154+ T cells predict liver ACR in children in a novel, 16-hour mixed leukocyte response (MLR) assay, but remain untested in SBTx. METHODS:The expression of CD154 was measured in 4 subsets-...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.04.006
更新日期：2009-08-01 00:00:00
abstract：:Eighteen patients with arteriovenous malformations (AVM's) involving the extremities, pelvis, or head are reported and their treatment is discussed. Our experience has led us to the following conclusions: (1) careful selective angiography is mandatory to delineate the vascular anatomy, extent, and major afferent vesse...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：INTRODUCTION:Routine, whole-body computed tomography imaging (PAN-SCAN) has been shown to identify unexpected injuries and alter the management of patients presenting with blunt trauma. We sought to characterize the changes in practice over time and the utility of PAN-SCAN imaging in elderly patients who fall and requi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.07.015
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:The effects of intestinal inflammation on the central nervous system are unknown. The dorsal motor nucleus of the vagus (DMNV) integrates peripheral and central signals and sends efferent signals to the gastrointestinal system. The purpose of this study was to determine the effects of intestinal inflammation...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.03.042
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Outcome for most abdominal wall defects is related to the presence or absence of additional anomalies or prematurity. In gastroschisis, outcome is almost as closely related to the severity of the inflammatory "peel" on bowel that is thought to result from direct contact with amniotic fluid. Improving eviscer...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:The object of this article is to assess the value of human serum albumin (HSA) in the initial resuscitation of hypotensive trauma victims. Thirty-six patients (mean age = 30 years) in shock from trauma who underwent laparotomies were randomly assigned to either Ringer's lactate solution (RL) resuscitation or 4% HSA in...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:Polypeptide growth factors have been shown to accelerate wound repair in rodent animal model systems. METHODS:In this report, insulin-like growth factor I (IGF-I) and the combination of IGF-I plus insulin-like growth factor binding protein (IGFBP-1) were applied directly to linear incisions made through dor...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Neuroendocrine tumors (NETs) are a potentially lethal component of multiple endocrine neoplasia type 1 (MEN 1). Somatostatin receptor scintigraphy (SRS) can be used to localize NETs and evaluate patients for extraduodenopancreatic disease; its utility in managing MEN 1 is undefined. METHODS:All patients wit...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1067/msy.1998.92553
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:The management of splenic injuries has evolved with a greater emphasis on nonoperative management. Although several institutions have demonstrated that nonoperative management of splenic injuries can be performed with an increasing degree of success, the impact of this treatment shift on outcome for all pati...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.06.032
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle al...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.01.017
更新日期：2004-07-01 00:00:00
abstract：:Lipopolysaccharide increases intestinal mucosal permeability to hydrophilic compounds such as chromium 51-labeled edetate (51Cr-EDTA). We sought to determine whether this phenomenon is partly mediated by lipopolysaccharide-induced mesenteric hypoperfusion. We assessed permeability in an isolated segment of ileum by me...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:Identification of the genes causing inflammatory bowel disease (IBD) would enhance the understanding of and the treatment options for this disease. A hyperreactive immune response toward the intestinal flora has been implicated in the pathology of IBD. The natural resistance-associated macrophage protein (NR...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90006-4
更新日期：1997-08-01 00:00:00
abstract：INTRODUCTION:Resident operative autonomy and case volume is associated with posttraining confidence and practice plans. Accreditation Council for Graduate Medical Education requirements for graduating general surgery residents are four liver and three pancreas cases. We sought to evaluate trends in resident experience ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.03.006
更新日期：2014-08-01 00:00:00
abstract：:Two patient groups were studied to determine the need to preserve the greater saphenous vein during femoral outflow reconstruction for later aortocoronary bypass procedures. First, 74 patients were followed to the time of death or to a minimum of 5 years after femoral outflow reconstruction was performed. Only four pa...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:We reviewed 137 patients with colon injury and applied multiple regression analysis to determine the influence of various parameters on colon-related infection. The complications of intra-abdominal abscess, wound infection, and peristomal abscess occurred in 25% of patients. The mortality rate was 3.6%, and four of fi...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
abstract：BACKGROUND:Management of critically ill patients is a challenge in low resource settings where there is a paucity of trained staff, infrastructure, resources, and drugs. We aimed to study the characteristics of surgical patients admitted in intensive care unit in a limited resource setting and determine factors associa...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.04.010
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Colonoscopy has had a major impact on the incidence and survival of colon cancer for patients who are screened, usually beginning at the age of 50. Meanwhile, the incidence rate of colon cancer is actually increasing in the patients younger than 50 while no routine screening is implemented for this age group...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.07.018
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The long-term consequences of in-hospital complications remain largely unknown. We sought to study the effect of complications on the long-term functional outcome of trauma patients. METHODS:Patients with an Injury Severity Score ≥ 9 admitted to 3, level I trauma centers between 2015 and 2017 were contacted...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.surg.2019.04.026
更新日期：2019-09-01 00:00:00
abstract：:The relationship of leukocytes, platelets, and thromboxane A2 (TxA2) to endotoxin-induced lung injury was studied by use of chronic pulmonary lymph fistula in 12 adult female sheep. Endotoxin-induced lung injury in sheep was characterized by an early pulmonary hypertensive phase followed by a phase of increased capill...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：PURPOSE:We have developed a novel molecular method of diagnosis using the technique of transcriptase-reverse transcriptase concerted reaction (TRC) for the detection of cancer micrometastasis. This study prospectively examined the clinical importance of the TRC diagnosis with peritoneal lavage fluids collected from gas...
journal_title：Surgery
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.surg.2013.10.004
更新日期：2014-03-01 00:00:00
abstract：:Early graft loss almost always occurs when recipients of a renal allograft develop antibody directed against antigens specific for donor vascular endothelial cells (VECs) and peripheral blood monocytes. In studies involving recipients of human leukocyte antigen identical, living-related grafts exhibiting preformed ant...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：BACKGROUND:Many aspects of the management of perforated appendicitis in children remain controversial. The objective of this study was to define risk factors associated with the development of postoperative complications in children undergoing treatment for perforated appendicitis. METHODS:We reviewed all children (ag...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.1998.91484
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:In patients with esophageal cancer and a history of gastric surgery, colonic interposition is the treatment of choice. Our aim was to review our experience with this technique and to identify possible predictors of the clinical outcome. METHODS:Between 1986 and 2006, 43 patients underwent esophageal reconst...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.10.045
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Operative interventions have traditionally been seen as expensive; therefore, surgery has been given low priority in global health care planning in low-income countries. A growing body of evidence indicates that surgery can also be highly cost effective in low-income settings, but our current knowledge of th...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.01.026
更新日期：2015-06-01 00:00:00
