Abstract：
:Lipopolysaccharide increases intestinal mucosal permeability to hydrophilic compounds such as chromium 51-labeled edetate (51Cr-EDTA). We sought to determine whether this phenomenon is partly mediated by lipopolysaccharide-induced mesenteric hypoperfusion. We assessed permeability in an isolated segment of ileum by measuring plasma-to-lumen clearances (C) for two probes, 51Cr-EDTA and urea, and expressing the results as a ratio (CEDTA/CUREA). In control pigs (n = 6) resuscitated with Ringer's lactate (RL), mucosal permeability was unchanged during the 210-minute period of observation. In pigs (n = 7) infused with lipopolysaccharide (50 micrograms/kg) and similarly resuscitated with RL, mesenteric perfusion (Qsma) decreased significantly and permeability increased progressively and significantly. When endotoxic pigs (n = 6) were resuscitated with a regimen (RL plus hetastarch plus dobutamine) that preserved normal Qsma, lipopolysaccharide-induced mucosal hyperpermeability was prevented. Resuscitation of endotoxic pigs (n = 6) with RL plus hetastarch provided intermediate protection against both mesenteric hypoperfusion and increased permeability. These data suggest that diminished Qsma contributes to impaired ileal mucosal barrier function in experimental endotoxicosis.
journal_name
Surgeryjournal_title
Surgeryauthors
Fink MP,Kaups KL,Wang HL,Rothschild HRsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
154-60; discussion 160-1issue
2eissn
0039-6060issn
1532-7361journal_volume
110pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:The recurrence rate for colorectal liver metastases after repeat hepatic resection is high, and selection criteria for repeat hepatectomy are still controversial. METHODS:Clinical data of patients undergoing repeat hepatectomy for metastatic colon cancer were reviewed retrospectively and compared with those...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2003.151
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Beta-cell destruction in type I diabetes mellitus results from a chronic autoimmune process. Exposure of thymic T cells to islet antigens during the prehyperglycemic phase of diabetes may alter the likelihood of autoimmune damage to beta cells in the native pancreas. Thus we evaluated whether prophylactic ma...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:An assessment was made of operative risk and outcome after parathyroidectomy for primary hyperparathyroidism. METHODS:A retrospective study was conducted in a single center university hospital in Switzerland. The 173 patients (130 women and 43 men) ranged from 17 to 89 years of age (mean, 62.0 years). No ro...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80058-3
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:This study was designed to compare the effects of hyperpolarizing versus depolarizing cardioplegic solutions on the coronary vasomotor regulation, specifically focusing on coronary myoplasmic Ca2+-myosin light chain (MLC) phosphorylation pathway and beta-adrenergic signal transduction. METHODS:With the use ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.107417
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:Surgical attempts to treat obesity began because of the discouraging results of conservative medical treatment, which successfully achieved initial weight loss but failed to maintain it. Gastric restrictive procedures, currently the most popular surgical methods for obesity therapy, have proved to be effecti...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80111-5
更新日期：1996-03-01 00:00:00
abstract：:Using software to transform magnetic resonance imaging (MRI) tomographic data into three-dimensional projections, we have produced "angiograms" of the abdominal aorta in 18 patients with occlusive (15) and aneurysmal (3) disease. This information may be displayed to demonstrate flow, cross-sectional diameter, or aorti...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:The clinical results of vascularized pancreas transplants have improved somewhat during the last 5 years, the but technical problems of handling the pancreatic duct remain difficult. Clinical isolated islet allografts have rarely if ever succeeded. Rejection appears to be a more severe problem in pancreas or islet tra...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：BACKGROUND:Preconditioning is injury-induced protection against subsequent injury and may be induced by a variety of stimuli. Both males and females may be preconditioned; however, if females are relatively protected against the initial insult, is their preconditioning threshold higher? We hypothesized that preconditio...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.03.016
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Neuroendocrine neoplasms most commonly metastasize to the liver. Operative extirpation of neuroendocrine neoplasm hepatic metastases improves symptoms and seems to improve survival, but subsequent evidence is required. The current study evaluates the progression-free survival and overall survival of patients...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.06.008
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Gastric cancer is an aggressive disease, and overall changes in incidence rates have been noted. There are conflicting data on whether young patients have worse outcomes than older patients; the roles of tumor biology and access to care are critical to answering this question. Our objectives were to explore ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.05.017
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:We report pharmacokinetic (PK) data, evaluation of modifications for increased stability, evaluation for cellular uptake, and mediation of regression of breast cancer for the aptamer OPN-R3. METHODS:The OPN-R3 aptamer was assessed for PK data in vivo with additional comparison of IV and subcutaneous dosing....
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.05.015
更新日期：2011-08-01 00:00:00
abstract：:The utility of fine-needle aspiration biopsy to detect carcinoma in thyroid nodules was evaluated by a decision-analysis approach in 102 patients. The procedure caused no morbidity. Cytologic diagnoses were categorized as unsatisfactory (4), no abnormality detected (61), atypical (13), suspicious for malignancy (14), ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:Operative resection is the only curative treatment for patients with pheochromocytomas, paragangliomas, and other catecholamine-producing neoplasms. Activation of glycogen synthase kinase 3beta (GSK3beta) is thought to promote tumor growth and neuroendocrine (NE) peptide secretion in NE neoplasms. Thus, we h...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.12.005
更新日期：2007-02-01 00:00:00
abstract：:Human beta-2 microglobulin (beta-2 M) is released into body fluids as a result of cell turnover, excreted by the kidney, and catabolized in the proximal tubule. Urinary excretion rates constitute a sensitive index of renal tubular function. The beta-2 M urine-to-serum ratio was measured in 25 patients with primary hyp...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:The acute and chronic changes produced in canine femoral arteries by ischemia and by perfusion with D10W were examined by light and by scanning electron microscopy. Mild changes of injury characterized by medial and adventitial inflammation and an increase in intimal lining cells occur following 30 minutes of perfusio...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1977-05-01 00:00:00
abstract：BACKGROUND:The gastrointestinal mucosa is an important route of entry for microbial pathogens. The immune cells of Peyer's patch (PP) compartments contribute to the active immune response against infection. Although local anesthetics are widely used in clinical practice, it remains unclear whether local anesthetics suc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.03.024
更新日期：2011-01-01 00:00:00
abstract：:Complete axillary dissection was performed in 287 patients undergoing modified radical mastectomy between 1984 and 1987 to identify patterns of axillary node metastases, as well as discontinuous axillary node ("skip") metastases. Positive pathologic findings were compared with preoperative clinical examinations in 266...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:We report a patient with malignant melanoma metastatic to the supraampullar portion of the common bile duct. The unique aspects of this case include its clinical presentation masquerading as obstructive jaundice caused by a bile duct tumor and the finding of an isolated solitary recurrence metastatic to the bile duct....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:The relationship between the cyclosporine A (CSA) dose and rejection of varying lengths of small-bowel grafts was studied in a rat heterotopic microsurgical small-bowel transplantation model involving a haploidentical strain combination. When Lewis X Brown Norway F1 hybrid (LBN) small-bowel grafts were transplanted in...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND:Right portal vein embolization has become popular in preparation for right hepatic lobectomy. However, right trisegment portal vein embolization (R3PE) is not well established. METHODS:We performed R3PE in 15 patients with biliary tract carcinoma and 1 patient with primary sclerosing cholangitis. We used 2 ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.101273
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Individual trials of small-volume resuscitation of 7.5% NaCl (HS) with and without 6% dextran 70 (HSD) for the treatment of trauma have failed to provide convincing evidence of efficacy. We performed a meta-analysis to evaluate the effects of HS and HSD on survival until discharge or for 30 days. We identifi...
journal_title：Surgery
pub_type： 杂志文章,meta分析
doi：10.1016/s0039-6060(97)90135-5
更新日期：1997-09-01 00:00:00
abstract：:From 1960 to 1988, 266 patients underwent resection of colorectal secondaries to the liver with curative intent. All patients were followed until April 1, 1990, or death, with a median follow-up time of 52 months. Nine patients with minimal macroscopic residual disease and 38 patients with all gross tumor removed but ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:We have previously shown that in a randomized comparison of laparoscopic (LC) versus small incision (SC) cholecystectomy, postoperative hospital stay is comparable. This randomized prospective study compares the postoperative pain, analgesic and antiemetic consumption, perceived health, and metabolic and res...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1067/msy.1998.87552
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:The long-term outcome of bilateral adrenalectomy in the management of patients with Cushing's syndrome has not been previously well studied. METHODS:We reviewed our long-term results in 34 patients treated with bilateral adrenalectomy between 1983 and the present. Fourteen presented with occult or metastati...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Venous thromboembolism, presenting as deep vein thrombosis or pulmonary embolism, can be associated with considerable morbidity after major abdominal and pelvic surgery. Perioperative thromboprophylaxis with low-molecular-weight heparin is well established, but the duration of treatment remains debated. We a...
journal_title：Surgery
pub_type： 杂志文章,meta分析
doi：10.1016/j.surg.2018.05.028
更新日期：2018-12-01 00:00:00
abstract：:An increase in the left ventricular end-diastolic pressure (LVEDP), resulting from the intravenous administration of blood, a colloid solution, or a crystalloid solution, was accompanied by an increase in both the inner:outer left ventricular wall flow ratio and the diastolic myocardial tissue pressure gradient. With ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-06-01 00:00:00
abstract：BACKGROUND:Benign thyroid cysts have been successfully treated with nonoperative sclerotherapy. Although OK-432 is a safe and effective sclerosing agent used to treat benign cystic lesions, little is known about its effectiveness in thyroid cysts. This study tested the efficacy of OK-432 sclerotherapy for thyroid cysts...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2008.06.014
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:In sepsis red blood cells (RBCs) have been shown to be less deformable (i.e., more rigid) and have been implicated in decreasing nutrient blood supply and possibly leading to organ dysfunction. However, no studies have demonstrated an association between organ dysfunction and rigid RBCs. This study examined ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:Eleven patients wtih gallstone-related acute pancreatitis underwent urgent duodenoscopy and diathermy sphincterotomy; six had stones impacted at the papilla of Vater, and the remainder had stones in the bile duct. One patient had a gallstone in the pancreatic duct. Endoscopic removal of the duct stones resulted in a p...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:The direct impact of burn injury on liver metabolism was studied in a rat liver perfusion system to remove the influence of systemic factors that modulate liver metabolism. METHODS:Seven animals received a burn injury covering 20% of the total body surface area, and seven were sham burned. The in situ liver...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90358-5
更新日期：1997-03-01 00:00:00
