Abstract:
BACKGROUND:The gastrointestinal mucosa is an important route of entry for microbial pathogens. The immune cells of Peyer's patch (PP) compartments contribute to the active immune response against infection. Although local anesthetics are widely used in clinical practice, it remains unclear whether local anesthetics such as lidocaine affect PP T cell functions. METHODS:The aim of this study was to examine if lidocaine has any effects on mouse PP T cell functions. To test this, freshly isolated mouse Peyer's patch T cells were incubated with lidocaine. The effects of lidocaine on concanavalin A-stimulated PP T cell proliferation and cytokine production were assessed. The effect of lidocaine on PP T cell mitogen-activated protein kinase (MAPK) activation was also assessed. RESULTS:The results indicate that lidocaine suppresses cell proliferation, cytokine production, and MAPK activation in PP T cells. Furthermore, we found that the chronic in vivo exposure to lidocaine increases bacterial accumulation in PP. CONCLUSION:The enhanced immunosuppressive effects of lidocaine on PP T cell functions could contribute to the host's enhanced susceptibility to infection.
journal_name
Surgeryjournal_title
Surgeryauthors
Kawasaki T,Kawasaki C,Sata T,Chaudry IHdoi
10.1016/j.surg.2010.03.024subject
Has Abstractpub_date
2011-01-01 00:00:00pages
106-13issue
1eissn
0039-6060issn
1532-7361pii
S0039-6060(10)00158-3journal_volume
149pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:Patients with locally advanced pancreatic cancer have historically been considered inoperable. The purpose of this report was to determine resectability rates for patients with locally advanced pancreatic cancer based on our recently described definitions of type A and type B locally advanced pancreatic canc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.09.012
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Adenosine released by cells during ischemia typically serves as a feedback inhibitor of further organ work. However, in ischemic intestine, adenosine appears to act via stimulatory A2b receptors to increase work in the form of chloride ion (Cl-) secretion. This unusual response may contribute to luminal flui...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80295-9
更新日期:1996-08-01 00:00:00
abstract::The outcome of 29 patients who underwent lung resection for treatment of metastatic malignant melanoma from January 1976 to November 1988 was studied. Twenty-two patients underwent total resection for cure of all apparent metastatic disease, whereas seven patients did not undergo total resection. Of the 22 patients wh...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Longitudinal, risk-adjusted measurement of outcomes of carotid artery (CA) surgery is necessary for the evaluation of quality performance and for the assessment of strategies of quality improvement. METHODS:Patients from quality coding hospitals who underwent CA surgery and met procedural and diagnostic cod...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.06.005
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Recurrent acute pancreatitis often leads to chronic obstructive ductal disease requiring operative decompression. METHODS:From 1983 through 1998, 124 patients with ductal obstruction underwent lateral pancreaticojejunostomy (78 patients), distal pancreatectomy with end-to-side pancreaticojejunostomy (27 pat...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::Hepatic ultrasonography (US) was performed during laparotomy in 47 patients with hepatocellular carcinomas (HCC) less than 5 cm in size. It detected more tumors than did preoperative US and other imaging modalities. In this series, 45.9% of HCCs smaller than 3 cm and 14.2% of those between 3 and 5 cm were invisible an...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:In the evaluation of patients with primary hyperparathyroidism (PHP), specific query for a personal or family history of MEN1 (Hx) is recommended widely, but responses are rarely positiv. We instituted a 6-question panel (6Q) to routinely screen for MEN1 preoperatively. METHODS:The clinical database entries...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.07.030
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Managing postoperative electrolyte imbalances often is driven by dogma. To identify areas of improvement, we assessed the practice pattern of postoperative electrolyte management among surgeons and residents. STUDY DESIGN:An online survey was distributed among attending surgeons and surgical residents at th...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.02.014
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Long-term outcomes after face transplantation are rarely reported in the scientific literature. Here we present outcome data of a partial face allograft recipient 10 years after transplantation. METHODS:Medical records were reviewed for functional and psychosocial outcomes as well as complications. Histopat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.01.010
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Obesity and type 2 diabetes are associated with renal dysfunction, which improves after Roux-en-Y gastric bypass (RYGB). During a 12-month follow-up period, we studied prospectively the changes in glomerular and tubular functions that occurred in excessively obese diabetic and non diabetic subjects after RYG...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.09.017
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the risk of recurrent laryngeal nerve palsy (RLNP) after thyroidectomy with routine identification of the recurrent laryngeal nerve (RLN) during the operation. METHODS:The present study was confined to 521 patients, 348 total lobectomies and 178 total thyroidectomies, tre...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.09.008
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Sphingosine-1-phosphate, a pleiotropic bioactive lipid mediator, is an important player in cancer progression. Previous studies suggested that sphingosine-1-phosphate produced by sphingosine kinase 1, which is activated by phosphorylation, plays important roles in the progression of disease and metastasis. T...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.11.024
更新日期:2018-06-01 00:00:00
abstract::Continuous ambulatory peritoneal dialysis (CAPD) is frequently used in the pediatric age group for reversible and end-stage renal failure. Most pediatric patients tolerate this therapy with few complications. Approximately 2% of children, however, develop massive unilateral hydrothorax. This major complication usually...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1991-04-01 00:00:00
abstract::We reviewed 137 patients with colon injury and applied multiple regression analysis to determine the influence of various parameters on colon-related infection. The complications of intra-abdominal abscess, wound infection, and peristomal abscess occurred in 25% of patients. The mortality rate was 3.6%, and four of fi...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:The landscape of patients with end-stage renal disease is changing with the increasing availability of kidney transplantation. In the near future, a less aggressive approach to treat secondary hyperparathyroidism might be beneficial. We report outcomes of parathyroidectomy for end-stage renal disease-related...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.08.014
更新日期:2021-02-01 00:00:00
abstract::Forty-five patients with varying biliary pathology were injected with one gram of intramuscular cefazolin sodium prior to surgery. Serum, gallbladder bile, and common duct bile levels were measured. The type of biliary disease did not influence serum levels (mean, 29 mug per milliliter) which reached a peak one hour a...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:A breast cancer (BC) history was elicited more frequently than expected among thyroid operation patients, which prompted an investigation of risks for concurrent or subsequent nonendocrine malignancies. METHODS:Of 94,939 patients at a tertiary referral center with breast, thyroid, or parathyroid disease fro...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.07.024
更新日期:2007-12-01 00:00:00
abstract::The intravenous infusion of amino acid and carbohydrate solutions is a well-established technique for nutritional support of the pediatric surgical patient. By using peripheral veins for total parenteral nutrition (TPN), weight gain can be achieved and the complications of central venous catheters avoided. Over a 2-ye...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:We hypothesized that intraoperative parathyroid hormone monitoring (IOPTH) reliably would detect double parathyroid adenomas. METHODS:This was a retrospective study of 20 patients undergoing conventional parathyroidectomy with resection of exactly 2 abnormal glands. Full exploration was performed regardless...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2001.118385
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Common anastomotic complications after pancreatoduodenectomy (PD) are leakage from the pancreaticojejunostomy or hepaticojejunostomy. Leakage from the gastroenteric anastomosis has rarely been described. We evaluated the incidence of gastroenteric leakage after PD and described its presentation, treatment, a...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.03.044
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Discussion of the volume-outcome relationship in pancreatic surgery has gained increasing interest. Currently, no data describe the situation in Germany. Pursuant to a recent legislative reform, a threshold of 10 operations per year was introduced for pancreatic surgery in 2006. This study describes the situ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.05.011
更新日期:2012-09-01 00:00:00
abstract::Intraoperative angioscopy provides direct, in vivo, three-dimensional visualization of the interior of the blood vessels and grafts. We have shown previously that with the application of the basic principles of irrigation and with a dedicated irrigation pump that routine intraoperative angioscopy can be performed with...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::We studied parathyroid hormone (PTH) release from cell suspensions of fresh and cryopreserved human parathyroid tissue. A sensitive PTH assay with midregion specificity and adaptation of "micro" methods of cell plating permitted conservation of tissue (200 microliters aliquots) and high reproducibility (5 to 10 aliquo...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the effects of treating human thyroid cancer cell lines with demethylating agents and histone deacetylase (HDAC) inhibitors to see if they would downregulate expression and activity of the matrix metalloproteinases (MMP)-2 and MMP-9, resulting in inhibition of gro...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.10.007
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Intestinal barrier failure during acute pancreatitis (AP) is associated with translocation of luminal bacteria, resulting in infectious complications. We examined the effects of multispecies probiotics on the intestinal barrier impairment in a murine model of AP. METHODS:Mice were injected with cerulein to ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.09.011
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Laparoscopy in patients with intra-abdominal malignancy remains controversial. This study evaluates the incidence of tumor recurrence at the port site after laparoscopy in patients with intra-abdominal malignancy. METHODS:The medical records of all patients with nongynecologic malignancies who underwent lap...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Large thyroid carcinomas extending into the anterior mediastinum were removed from six patients by a transsternal surgical approach (partial median sternotomy). Transcervical mediastinal dissection offers obscure exposure and therefore entails the risk of the operation not being radical. The transsternal procedure was...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Data from a US multicenter longitudinal study of bariatric surgery were used to compare weight change (primary outcome) and comorbidities (secondary outcome) in patients who underwent sleeve gastrectomy versus Roux-en-Y gastric bypass. METHODS:This study includes participants who underwent sleeve gastrectom...
journal_title:Surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.surg.2018.06.008
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:We have developed a novel molecular method of diagnosis using the technique of transcriptase-reverse transcriptase concerted reaction (TRC) for the detection of cancer micrometastasis. This study prospectively examined the clinical importance of the TRC diagnosis with peritoneal lavage fluids collected from gas...
journal_title:Surgery
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.surg.2013.10.004
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Parathyroid autotransplantation (PTHAT) during thyroidectomy has been shown to reduce the incidence of permanent hypoparathyroidism. Although selective PTHAT is most commonly adopted, the value of routine PTHAT has not been well documented. METHODS:From January, 1998 to March, 1999, an operative strategy in...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2001.111125
更新日期:2001-03-01 00:00:00