Abstract：
BACKGROUND:Adenosine released by cells during ischemia typically serves as a feedback inhibitor of further organ work. However, in ischemic intestine, adenosine appears to act via stimulatory A2b receptors to increase work in the form of chloride ion (Cl-) secretion. This unusual response may contribute to luminal fluid sequestration in intestinal ischemia. In nonischemic cells feed-forward activation of Cl- secretion does not occur despite the fact that adenosine may be continuously generated during normal cell metabolism. Thus we postulated that intestinal epithelia normally control the disposition of adenosine to prevent inappropriate activation of secretion. METHODS:Model T84 intestinal epithelia were studied by means of electrophysiologic and isotopic techniques. RESULTS:Dipyridamole and nitrobenzylthioinosine (inhibitors of nucleoside transport) and iodotubercidin (an inhibitor of adenosine kinase) caused adenosine to accumulate extracellularly and induced a Cl- secretory response that was prevented by adenosine receptor blockade. Uptake of exogenous adenosine was restricted to the basolateral compartment and was blocked by nucleoside transport inhibitors. CONCLUSIONS:Adenosine released from nonischemic intestinal epithelial cells is scavenged by a basolaterally restricted adenosine transporter. This system maintains extracellular adenosine levels below the prosecretory threshold and thus limits adenosine-elicited activation of Cl- secretion (and hence diarrhea) under normal conditions).
journal_name
Surgeryjournal_title
Surgeryauthors
Tally KJ,Hrnjez BJ,Smith JA,Mun EC,Matthews JBdoi
10.1016/s0039-6060(96)80295-9subject
Has Abstractpub_date
1996-08-01 00:00:00pages
248-54issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(96)80295-9journal_volume
120pub_type
杂志文章相关文献
SURGERY文献大全abstract：:From 1960 to 1988, 266 patients underwent resection of colorectal secondaries to the liver with curative intent. All patients were followed until April 1, 1990, or death, with a median follow-up time of 52 months. Nine patients with minimal macroscopic residual disease and 38 patients with all gross tumor removed but ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Little is known about the response of surface cells and glandular cells of the gastric mucosa to various injurious agents. This study examines the effects of bile acid and salicylate on oxygen consumption and membraneolysis of isolated gastric mucosal surface cells and compares these responses to those of cells consti...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
abstract：:From 1979 to 1990, 33 children required operative treatment for pancreatitis. Causes included ductal abnormalities (12 children), trauma (10 children), idiopathic (four children), gallstones (three children), drug-induced (three children), and tumor (one child). This study reviews the characteristics and outcome of th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:The emergence of both absorbable and nonabsorbable synthetic materials has been primary among the many new developments in suture materials. This is a study of 16 types of natural and synthetic suture materials and their resistance to both gram-positive and gram-negative infections. Four hundred and twenty suture inpl...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The shear stress resistance of cultured human endothelium was investigated on 6 mm polytetrafluoroethylene vascular grafts. Endothelial cell attachment was promoted by precoating the grafts with fibrin glue, which contained human fibronectin and inhibitors of fibrinolysis (aprotinin and tranexam acid). To evaluate the...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:Diaphragm pacing (DP) can replace mechanical ventilation in tetraplegics and in trials has assisted respiration in amyotrophic lateral sclerosis patients. This report describes results of DP in patients with cardiac pacemakers. METHODS:Prospective, single-center and multicenter, nonrandomized, controlled, i...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.surg.2010.07.008
更新日期：2010-10-01 00:00:00
abstract：:The incidence of fascial disruption after major abdominal operations is 1% to 3%, and dehiscence is associated with a mortality rate of 15% to 20%. Although several systemic factors (e.g., malnutrition, increased age, male sex, and chronic treatment with steroids) have been associated with an increased risk of wound d...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：BACKGROUND:Epistemic Network Analysis (ENA) is a technique for modeling and comparing the structure of connections between elements in coded data. We hypothesized that connections among team discourse elements as modeled by ENA would predict the quality of team performance in trauma simulation. METHODS:The Modified No...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.11.009
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Necrotizing Clostridium septicum infections (CSI) have a strong association with malignancy or immunosuppression. To clarify this relationship and determine how it impacted mortality, the experience with CSI at a single institution was reviewed. METHODS:Records of all patients admitted to our hospital with ...
journal_title：Surgery
pub_type： 杂志文章,评审
doi：10.1016/s0039-6060(05)80023-6
更新日期：1995-10-01 00:00:00
abstract：:We studied 28 patients who had undergone 30 operations for pheochromocytoma since 1964. The tumor types included bilateral, extra-adrenal, malignant, recurrent, and multiple endocrine neoplasia, with 20 tumors confined to the adrenal gland. The preoperative studies used to localize the tumor included ultrasonography, ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine whether nitric oxide regulates insulin secretion in the isolated perfused human pancreas. METHODS:Single-pass perfusion was performed in four pancreata with a modified Krebs medium. Sequential 10-minute infusions (separated by 10-minute basal periods) of (1) 25 nmo...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80305-9
更新日期：1996-08-01 00:00:00
abstract：:Extensive calcification of a pancreatic pseudocyst that permits visualization on plain abdominal radiographs is unusual. When such x-ray findings are encountered, a broad differential diagnosis can be made, which includes tumors, cysts, abscesses, or malformations of the adjacent structures. Two cases of calcified pan...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:To study the role of antibodies in promoting survival during gram-negative bacterial sepsis, we have developed several murine monoclonal antibodies (MAbs). One MAb (5B10) reacted in an enzyme-linked immunosorbent assay with only a single organism (Escherichia coli 0111:B4), while the other (8A1) reacted to all gram-ne...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：BACKGROUND:Hypoparathyroidism is the most frequent permanent complication of thyroid surgery. Our hypothesis is that human precursor cells in culture can be differentiated into parathyroid cells and used to reconstitute function. Human embryonic stem cells (hESCs) are a stable model to study differentiation into parath...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.09.021
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Studies of risk factors after pancreatoduodenectomy are few: some concern restricted populations and others are based on administrative data. METHODS:Multicenter clinical data were collected for 300 patients undergoing pancreatoduodenectomy to determine (by univariate and multivariate analysis) preoperative...
journal_title：Surgery
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.surg.2005.08.012
更新日期：2006-05-01 00:00:00
abstract：:The influence of cimetidine on blood flow to the gastric corpus and antrum of the dog was studied using the double isotope microsphere distribution technique. This H2 receptor antagonist caused no changes in blood flow to any portion of the stomach nor did it alter systemic circulatory parameters. The therapeutic effe...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:Expendable autologous nerve available for repair of nerve injuries is limited. Cadaveric allografts could provide adequate nerve for grafting but are susceptible to rejection and currently require chronic systemic immunosuppression. METHODS:Age-matched Buffalo (RT1B) rats randomly assigned to 7 experimental...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Managed care organizations use a variety of payment strategies to contract for high-end tertiary services with academic healthcare centers. We assessed the financial outcome of these strategies and attempted to identify those that maintain a balance between cost and reimbursement. METHODS:Patients admitted ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(03)00329-5
更新日期：2003-10-01 00:00:00
abstract：:Direct measurement of the femoral artery pressure before operation has been used to predict the postoperative change in ankle and toe pressure in 102 limbs (83 patients) that underwent aortoiliac surgery for the treatment of atherosclerotic occlusion or stenosis affecting both the aortoiliac and femoral artery segment...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：BACKGROUND:Operative time often has been cited as an important factor for postoperative outcomes. Despite this belief, most efforts to improve liver transplant outcomes have largely focused on only patient and donor factors, and little attention has been paid on operative time. The primary objective of this project was...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.05.010
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:To avoid the complications associated with overfeeding or underfeeding, the energy requirements of patients receiving total parenteral nutrition (TPN) must be accurately prescribed. However, until recently it has not been possible to directly measure the rates of total energy expenditure (TEE) in surgical pa...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0039-6060(05)80010-8
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:von Hippel-Lindau disease is an autosomal dominant disorder characterized by the development of hemangioblastomas in the cerebellum, spinal cord, and retina, renal cell carcinoma and cysts, pancreatic cysts, and pheochromocytoma. METHODS:We have studied a series of 36 French patients affected with von Hippe...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:Surgical residents have traditionally been evaluated by ward evaluations and multiple-choice testing; overall resident performance has seldom been objectively evaluated. We developed a comprehensive evaluation program for senior residents. The purpose of this study was to determine whether the several differ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:Wound complications after lower extremity arterial reconstruction can range from a minor lymphatic leak that causes minimal disability to a severe infection that jeopardizes the limb and life of the affected patient. This study was designed to define more clearly the incidence, severity, and the cost of thes...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80135-8
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:Adrenal cortical carcinoma (ACC) is a rare disease in which recurrence after surgery is common. Mitotane is the primary systemic treatment for recurrent ACC; data are limited regarding the impact of mitotane on recurrent ACC. METHODS:We reviewed the records of all patients who underwent surgery for ACC eval...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.09.006
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Congenital extrahepatic portosystemic shunt (CEPS) is a rare venous malformation in which mesenteric venous blood drains directly into the systemic circulation. It is still a matter of debate whether conservative or operative strategies should be used to treat symptomatic CEPS. The aim of this study...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.07.035
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Patients with primary hyperparathyroidism often lack classic symptoms but can have reductions in bone mineral density and increased fracture risk. We sought to determine bone mineral density improvement after successful surgery and associated factors. METHODS:A review of patients with osteopenia or osteopor...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.08.015
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:The hypothesis of this study was that differences exist among patients with private insurance compared with patients with Medicaid or no insurance, regarding access to the timely treatment of abdominal aortic aneurysms (AAAs) and the outcomes of AAA repair. METHODS:The study comprised 5363 patients aged les...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2003.214
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Effective cytoprotection to xenoislets would circumvent the major tissue limitation for pancreatic islet transplantation (PIT). Cell-surface engineering with poly[ethylene glycol] (PEG) derivatives can successfully prevent antibody binding to the surface antigens. Gene transfer of the antiapoptotic Bcl-2 gen...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.05.031
更新日期：2004-09-01 00:00:00
abstract：:A model for the vascular steal phenomenon was designed and evaluated in 10 mongrel dogs in which the aortic bifurcation was used to represent a parent artery with two distal vascular beds. Right lower extremity flow was increased with a femoral arteriovenous fistula, and progressively greater stenoses were applied to ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
