Abstract:
:Little is known about the response of surface cells and glandular cells of the gastric mucosa to various injurious agents. This study examines the effects of bile acid and salicylate on oxygen consumption and membraneolysis of isolated gastric mucosal surface cells and compares these responses to those of cells constituting the gastric glands. The effects of salicylate and bile acid on oxygen consumption by surface cells are similar to previous observations for intact gastric glands and isolated mitochondria, indicating alterations of oxidative phosphorylation. Salicylate does not appreciably alter lipid release from either surface or glandular cells. However, bile acid causes a profound increase in lipid release from both surface and glandular cells. Salicylate does not alter the number of visibly intact surface or glandular cells, but 1 mM of taurocholic acid decreases the number of surface cells by 45% without altering the glandular cells. In contrast, 5 mM of taurocholic acid completely destroys the surface cells and reduces the number of gastric glandular cells by 51%. These data suggest that surface cells are more susceptible to membraneolytic effects of bile acid than are gastric glandular cells. This may account for the superficial nature of bile acid-induced injury to the gastric mucosa. Although both bile acid and salicylate interfere with oxidative metabolism, this effect alone does not appear to account for cellular destruction.
journal_name
Surgeryjournal_title
Surgeryauthors
Tanaka K,Fromm Dsubject
Has Abstractpub_date
1983-05-01 00:00:00pages
660-3issue
5eissn
0039-6060issn
1532-7361pii
0039-6060(83)90265-9journal_volume
93pub_type
杂志文章相关文献
SURGERY文献大全abstract::During a 30-month period 73 patients underwent operation for choledocholithiasis. Thirty-three of these patients (45%) had cholangitis preoperatively. When compared to patients with common duct stones who had no preoperative cholangitis, patients with cholangitis were older (P less than 0.001), more likely to present ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract::Serial determinations of human thymus-dependent (T) and bone marrow-dependent (B) peripheral blood lymphocytes were performed to detect changes in activity of these rosette-forming cells in five groups of patients: controls; chronic renal failure (CRF) patients; dialysis patients receiving pretransplant splenectomy; 5...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract::Advances in radiation techniques and increased dosage have improved the cure rate of patients with cancer of the cervix to 65 percent. Associated with this increased dosage (betatron, 5,250 r and intracavitary 137-cesium, 4,000 r at point A) has been a serious complication incidence of 10 percent. Major intestinal com...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND:Patient-reported outcomes are measured in chronic disease states to inform intervention and management decisions while minimizing negative outcomes. We hypothesized that health-related quality of life in patients with multiple endocrine neoplasia type 2A would be worse than the general US population but simi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.04.036
更新日期:2018-09-01 00:00:00
abstract::Two granular cell tumors of the biliary tree are described, one in a 37-year-old black woman with obstructive jaundice and the other in a 26-year-old white woman with abdominal pain. These are rare soft tissue tumors that have an excellent prognosis when surgically excised. Almost all reported cases have been in young...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Many aspects of the management of perforated appendicitis in children remain controversial. The objective of this study was to define risk factors associated with the development of postoperative complications in children undergoing treatment for perforated appendicitis. METHODS:We reviewed all children (ag...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.1998.91484
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Our aim was to examine the outcomes of patients with tertiary hyperparathyroidism (3-HPT) who had limited resection of 1 or 2 parathyroids. METHODS:We reviewed 140 patients with 3-HPT who underwent parathyroidectomy (PTX) at a single institution. Patients were analyzed according to their operation-limited P...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.09.026
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NACT) has been frequently used for locally advanced esophageal squamous cell cancer (ESCC). It is therefore important to establish criteria for evaluating the response to NACT based on survival analysis. METHODS:This study analyzed 100 patients with ESCC (cT1, 2/3/4:25/57/18, cN0/1...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.02.016
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Gross vascular invasion is a well-established prognostic indicator in hepatocellular carcinoma (HCC), but the biological significance of microscopic invasion remains unclear. METHODS:Curatively resected primary HCCs were classified retrospectively into 3 groups: HCCs without vascular invasion (V0), HCCs wit...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.09.037
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:In patients with esophageal cancer and a history of gastric surgery, colonic interposition is the treatment of choice. Our aim was to review our experience with this technique and to identify possible predictors of the clinical outcome. METHODS:Between 1986 and 2006, 43 patients underwent esophageal reconst...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.10.045
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Postoperative cervical hemorrhage is a rare but life-threatening complication that can cause severe morbidity. Different mechanisms leading to asphyxia have been described based only on clinical observation. METHODS:We performed a series of in vivo animal studies simulating post-thyroidectomy hemorrhage and...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.05.022
更新日期:2018-09-01 00:00:00
abstract::Recently, serum was shown to contain a factor that increased expression of the complement receptor CR3 on neutrophil membranes. This factor was localized to platelet granules and was released during coagulation. This study was undertaken to identify this factor in platelet granules. Platelet supernatants containing gr...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine if systemic acidosis induced by peritoneal absorption of carbon dioxide (CO2 ) during laparoscopy plays a role in CO2 pneumoperitoneum-mediated attenuation of the acute phase inflammatory response associated with perioperative sepsis. The influence of hepatic polymo...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.01.005
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Results of the conservative treatment of renal cell carcinomas arising in functional renal transplants are unknown compared to transplant nephrectomy. Only small series or case reports have been reported. METHODS:Data were collected from 32 transplantation centers nationwide on cases of de novo tumors in fu...
journal_title:Surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.surg.2016.01.022
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:We hypothesized that acetylation of the Stat1 regulates interferon-gamma (IFN-gamma) mediated macrophage expression of inducible nitric oxide synthase (iNOS). METHODS:RAW 264.7 iNOS expression was induced with IFN-gamma. Deacetylase inhibitors trichostatin A (TSA) or valproic acid (VPA) were added. Stat1 an...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.02.016
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Salvage liver transplantation (SLT) has been proposed for recurrent hepatocellular carcinoma (HCC) after hepatectomy; however, it is unclear how the time interval to tumor recurrence from previous hepatectomy affects prognosis. METHODS:We analyzed retrospectively the outcomes of 62 patients who underwent SL...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.09.018
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The presence or absence of lymph node metastases is known to be an important prognostic factor for patients with pancreatic cancer. Few studies have investigated the ratio of the number of lymph nodes harboring metastatic cancer to the total number of lymph nodes examined (lymph node ratio [LNR]) with regard...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2006.12.013
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:The gastrointestinal mucosa is an important route of entry for microbial pathogens. The immune cells of Peyer's patch (PP) compartments contribute to the active immune response against infection. Although local anesthetics are widely used in clinical practice, it remains unclear whether local anesthetics suc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.03.024
更新日期:2011-01-01 00:00:00
abstract::The purpose of this project was to evaluate the acute and chronic effects of sclerotherapy on esophageal motility and function. We studied motility in eight patients before and after injection sclerotherapy of esophageal varices. We injected the varices with 5% sodium morrhuate twice during the first week and then at ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract::One hundred thirty-three patients with familial adenomatous polyposis undergoing colectomy and ileorectal anastomosis have been reviewed for the occurrence of cancer in the rectal stump. Ten patients developed rectal cancer (Actuarial survivorship rate of 88% for those patients free of rectal cancer at 20 years). Pote...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::The hydrogen gas clearance technique was evaluated to estimate regional hepatic blood flow. Initially, the H2 gas method was compared to the indocyanine green clearance in mini pigs. The blood flow measured by the H2 gas method (0.49 +/- 0.03 ml/min/gm) was only 39% of the calculated blood flow by the indocyanine gree...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:Growth hormone supplementation has been shown to stimulate muscle protein synthesis and to improve nitrogen balance in a variety of catabolic states. The role of growth hormone to support the tumor-bearing host is complicated by the risk that growth hormone or its intermediaries may stimulate tumor growth. T...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80199-0
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Epithelialization of cutaneous ulcers is a long-lasting process. To study the pathomechanism of impaired epithelialization, we evaluated the role of cell cycle- and apoptosis-related proteins in the regenerating epidermis. We characterized immunohistochemically the expression of cell cycle regulators p63, CD...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2003.223
更新日期:2003-08-01 00:00:00
abstract::We have reported on a patient with isolated metachronous renal artery emboli. The second embolus was treated successfully surgically 12 hours after the onset of symptoms. A review of the literature shows that emboli to the renal arteries occur more frequently than realized and that late embolectomy often is successful...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1976-01-01 00:00:00
abstract::Lymphokines, the soluble molecules produced by cells of the immune system, regulate cell-cell interactions and, consequently, the functional status of the immune system. Altering immunoregulatory pathways with lymphokines in vivo may provide a mechanism for controlling a variety of immunologic disorders. Although norm...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract::In this study we evaluated the capacity of selective angiography to reduce the number of exploratory procedures with negative results for suspected peripheral vascular injury. During the 4-year period ending December 1982, 316 trauma patients were evaluated for possible vascular injuries of the extremities. Exploratio...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:The aim of this prospective randomized controlled study was to investigate the effects of continuous venovenous hemofiltration on the hemodynamics and respiratory function of critically ill trauma patients with multiple organ dysfunction syndrome. METHODS:Thirty consecutive critically ill, mechanically vent...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0039-6060(97)90331-7
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Bilateral axillo-breast approach (BABA) robotic thyroidectomy (RoT) has good postoperative and excellent cosmetic outcomes. To assess the surgical completeness of BABA RoT, it was compared to open thyroidectomy (OT) after propensity score matching of the cohorts. METHODS:Between 2008 and 2010, 760 patients ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.09.015
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The world's poorest 2 billion people, benefit from no more than about 3.5% of the world's operative procedures. The burden of surgical disease is greatest in Africa, where operations could save many lives. Previous facility-based studies have described operative procedure caseloads, but prospective studies i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.03.022
更新日期:2015-07-01 00:00:00
abstract::Pancreatic polypeptide (PP) deficiency has been associated with impaired hepatic sensitivity to insulin and pancreatogenic diabetes in chronic pancreatitis. Since pancreatic resection might also result in PP deficiency, hepatic responses to insulin infusion (0.25 mU/kg/min) were determined by the euglycemic glucose cl...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00