Serial changes in arterial endothelium following ischemia and perfusion.

Abstract:

:The acute and chronic changes produced in canine femoral arteries by ischemia and by perfusion with D10W were examined by light and by scanning electron microscopy. Mild changes of injury characterized by medial and adventitial inflammation and an increase in intimal lining cells occur following 30 minutes of perfusion with return to a normal microscopic appearance within one week. Perfusion for 6 hours produces significant injury to the entire arterial wall, as evidenced by depletion of cells and elastin from the media, replacement with collagen, and eventual fibrosis. The intimal surface is replaced by a layer of spindle cells which appear to originate in the media. The internal elastic membrane is flattened and thrombosis is prominent, particularly in areas where medial fibrosis is severe. Many of the vascular changes produced by perfusion injury may persist for 3 months and some may even by permanent. A period of 6 hours of ischemia also produces similar but less prominent alterations in vascular morphology which return to near-normal appearance within 8 weeks.

journal_name

Surgery

journal_title

Surgery

authors

Fonkalsrud EW,Sanchez M,Zerubavel R,Mahoney A

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

527-33

issue

5

eissn

0039-6060

issn

1532-7361

pii

0039-6060(77)90209-4

journal_volume

81

pub_type

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