Abstract：
:Human beta-2 microglobulin (beta-2 M) is released into body fluids as a result of cell turnover, excreted by the kidney, and catabolized in the proximal tubule. Urinary excretion rates constitute a sensitive index of renal tubular function. The beta-2 M urine-to-serum ratio was measured in 25 patients with primary hyperparathyroidism (15 preoperative and 10 treated conservatively) in addition to 20 age- and sex-matched control subjects. The ratio was found to be significantly higher in both the operative and the conservatively managed groups compared to controls (p less than 0.05, Mann-Whitney U test). After surgical excision of a single parathyroid adenoma in the 15 operative cases, the beta-2 M urine-to-serum ratio fell to normal limits. These preliminary findings indicate that the urine-to-serum beta-2 M ratio may be of value in detecting change in renal function in asymptomatic patients with hyperparathyroidism. Further studies are indicated to establish whether these subtle changes are associated with long-term morbidity.
journal_name
Surgeryjournal_title
Surgeryauthors
Goode AW,Jenkins BJ,Monson JP,Sprague DB,Donaldson PJ,Toms GCsubject
Has Abstractpub_date
1987-12-01 00:00:00pages
914-6issue
6eissn
0039-6060issn
1532-7361pii
0039-6060(87)90317-5journal_volume
102pub_type
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