Abstract：
BACKGROUND:The direct impact of burn injury on liver metabolism was studied in a rat liver perfusion system to remove the influence of systemic factors that modulate liver metabolism. METHODS:Seven animals received a burn injury covering 20% of the total body surface area, and seven were sham burned. The in situ liver perfusion studies were carried out in these animals after 3 days of isonitrogenous-isocaloric enteral feeding. In each study oxygen consumption and the rates of uptake and release of glucose, urea, and various amino acids were measured. RESULTS:Burn injury significantly increased urea production (18.5 +/- 0.4 versus 12.2 +/- 0.6 micromol/gm liver/hr and oxygen consumption (3.23 +/- 0.17 versus 1.21 +/- 0.03 micromol/gm liver/min) in the liver but did not alter the rate of gluconeogenesis. The change in amino acid concentrations in the perfusion medium implies an increased net protein breakdown. CONCLUSIONS:Our study indicates that (1) burn injury induces a hypermetabolic state in the liver, (2) the observed enhancement of gluconeogenesis in vivo after burn in probably regulated by factors outside the liver, and (3) the liver itself plays an active role in up-regulating urea production in burn injury. Identifying intrahepatic factors that up-regulate urea production may provide an "intrahepatic approach" to ameliorate the severe nitrogen loss after burn injury.
journal_name
Surgeryjournal_title
Surgeryauthors
Yamaguchi Y,Yu YM,Zupke C,Yarmush DM,Berthiaume F,Tompkins RG,Yarmush MLdoi
10.1016/s0039-6060(97)90358-5subject
Has Abstractpub_date
1997-03-01 00:00:00pages
295-303issue
3eissn
0039-6060issn
1532-7361pii
S0039-6060(97)90358-5journal_volume
121pub_type
杂志文章相关文献
SURGERY文献大全abstract：:The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared wi...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：:An abdominal operation combines a somatic abdominal wall wound with a second autonomic wound to the peritoneal cavity and viscera and little attention has been paid the autonomic/peritoneal wound that communicates directly to the brain by the vagus nerve. Moreover, vagal input originating from the peritoneum modulates...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.10.020
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:A diverting stoma is often performed at the time of low anterior resection (LAR) for rectal cancer after neoadjuvant chemoradiation (nCRT) to protect the anastomosis. The aim of this study was to compare surgical outcomes in large cohorts of mid-high rectal cancer patients undergoing LAR after nCRT with an...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.02.026
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Our ability to predict respiratory compromise during general anesthesia in a child with an anterior mediastinal mass is limited. Two prior reports have found a correlation between adequacy of ventilation during general anesthesia and the tracheal cross-sectional area obtained from computed tomograms (compute...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80360-5
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:The traditional tools to assess surgical capacity in low-income countries require significant amounts of time and resources, and have thus not been utilized systematically in this context. Proxy indicators have been suggested as a simpler tool to estimate surgical volume. The aim of this study was to assess ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.12.014
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Measuring patient work of breathing (WOBpt) has been suggested to provide safe, aggressive weaning from mechanical ventilation. We compared WOBpt and pressure-time-product (PTP) to routine weaning parameters [breath rate (f), tidal volume (VT), frequency/tidal volume ratio (f/VT)] at different levels of pres...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0039-6060(97)90081-7
更新日期：1997-10-01 00:00:00
abstract：:Eleven patients wtih gallstone-related acute pancreatitis underwent urgent duodenoscopy and diathermy sphincterotomy; six had stones impacted at the papilla of Vater, and the remainder had stones in the bile duct. One patient had a gallstone in the pancreatic duct. Endoscopic removal of the duct stones resulted in a p...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:We present the largest single-center study to date of surgical and quality-of-life outcomes among patients treated with laparoscopic antireflux surgery for reflux-associated chronic cough. Extraesophageal manifestations of chronic gastroesophageal reflux are increasingly recognized, among which chronic cough...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.01.036
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Approximately 10% of patients taking lithium for manic-depressive disorders become hypercalcemic. It remains unclear whether lithium initiates disease or promotes underlying hyperparathyroidism. We have previously demonstrated that at therapeutic concentrations lithium stimulates in vitro incorporation of bo...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80258-2
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:A left hepatic graft in living donor liver transplantation (LDLT) often has 2 thin and short hepatic arterial stumps, which makes hepatic artery (HA) reconstructions much more difficult to perform. Consequently, some investigators regard using a left graft as a contraindication to LDLT, whereas others report...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.06.028
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Occasionally, lung transplant candidates improve to the point where they are removed from the transplant list. We sought to determine the characteristics and outcomes of lung transplant candidates who improved to delisting both before and after implementation of the lung allocation score. METHODS:Using the ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.07.009
更新日期：2019-12-01 00:00:00
abstract：:The central venous dialysis catheter has gained wide acceptance for short-term hemodialysis with the realization of the need to spare peripheral extremity vessels for the creation of more durable internal arteriovenous fistulas. The Hemocath (Quinton Instrument Co., Seattle, Wash.), a soft, silicone rubber, double-lum...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:In a 2-year period 30 patients with persistent hyperparathyroidism following 59 prior unsuccessful procedures underwent reoperation. Preoperative arteriography was useful in planning the surgical approach in 56%, and retrospectively was correct in 63%. Selective venous catheterization gave localizing information in 83...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
abstract：BACKGROUND:Aggressive screening for blunt cerebrovascular injury (BCVI) and prompt anticoagulation for documented injuries has resulted in a significant reduction in ischemic neurologic events. An association between vertebral artery injuries (VAIs) and specific cervical spine fracture patterns has been suggested; howe...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.04.005
更新日期：2007-01-01 00:00:00
abstract：:Deficiencies in the immune system that lead to increased morbidity and mortality from infectious complications have been well documented in patients suffering from trauma, malnutrition, sepsis, and thermal injuries. We investigated the potential benefit of immune stimulation for preventing infection in such conditions...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:A patient's condition was initially diagnosed as constrictive pericarditis, but an echocardiogram revealed the presence of an intracardiac tumor. The tumor was a slow-growing leiomyosarcoma that originated in the left internal iliac vein, extended into the inferior vena cava, and reached the right ventricle. This tumo...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：BACKGROUND:The most common cause of noncurative resection and recurrence is gastric cancer is peritoneal seeding. However, the results of treatment of peritoneal dissemination with chemotherapy have been poor with 5-year survival rates of 0%. METHODS:A new in vitro thermochemosensitivity test was performed on gastric ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80145-0
更新日期：1996-04-01 00:00:00
abstract：:We report a case in which a large, postoperative, biliary cutaneous fistula was successfully treated by means of endoscopic insertion of two endoprostheses into the common bile duct. Twenty-four hours after the procedure, bile flow from the cutaneous fistula ceased completely. The endoprostheses were removed after 6 w...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:We prospectively sampled 38 large soft tissue masses in 37 patients with both core needle biopsy (CNBX) and fine-needle aspiration (FNA) to determine the diagnostic utility of these biopsy methods. In 27 cases the histologic diagnosis made from the resected specimen was compared with the diagnosis based on the biopsy....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:Twenty dogs underwent 15 minutes of normothermic ischemic arrest and 30 minutes of reperfusion while on cardiopulmonary bypass. In 10 control dogs, the reperfusate blood was not modified. In 10 other dogs, the aorta was reclamped and the heart reperfused for 5 minutes with blood containing L-glutamate (0.026M). We mea...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
abstract：:A patient with an uncommon cause of portal venous hypertension, pancreatitis, is depicted. The patient had an equally uncommon pattern of symptoms and signs consisting of abdominal pain and lower gastrointestinal hemorrhage caused by colonic varices. A unique treatment, with angiographic placement of an expandable int...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Giant duodenal ulcer (GDU) is generally thought to require surgical intervention. Proton pump inhibitors have beneficial effects in peptic ulcer disease, but their role in GDU disease is unknown. We examined the use of omeprazole in GDU management. METHODS:Twenty-eight patients were diagnosed with GDU. One ...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Statewide trauma systems are implemented by health care policy makers whose intent is to improve the process of care delivered to seriously injured patients. In Oregon, Advanced Trauma Life Support (ATLS) training was mandated for all physicians employed in the emergency department of trauma centers. The pur...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1067/msy.2001.115898
更新日期：2001-08-01 00:00:00
abstract：:The effect of a new extracorporeal system combining direct hemoperfusion (DHP) with venovenous bypass was evaluated in the elimination of anticancer drugs in hepatic artery infusion. Adriamycin (3 mg/kg) and mitomycin C (1 mg/kg) were given to mongrel dogs through the hepatic artery with three different durations of 1...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:We previously demonstrated that therapy with a new endothelin A receptor antagonist (ET-RA) significantly reduced mortality rates in severe acute pancreatitis (AP) in the rat without attenuating local signs of disease severity (intrapancreatic protease activation, acinar cell necrosis). This raised the quest...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.107104
更新日期：2000-09-01 00:00:00
abstract：:The smuggling of illicit drugs by concealing them within the human body has become a widespread practice. Those individuals who transport packaged drugs are commonly known as "body packers" or "mules". "Body stuffers," on the other hand, are individuals who emergently place the contraband in a body orifice when they s...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:Obese patients can develop a large lower abdominal panniculus (worsened by significant weight loss). Patients with advanced chronic kidney disease (CKD) affected by this obesity-related sequela are not infrequently declined for kidney transplantation because of the high risk for serious wound-healing complic...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.12.001
更新日期：2016-06-01 00:00:00
abstract：CONTEXT:The rate and the extent of bone remineralization at cancellous versus cortical sites after treatment of hyperthyroidism is unclear. Few studies have examined the effect of operative management of hyperthyroidism on recovery of bone mass. OBJECTIVE:To evaluate prospectively the bone mineral density (BMD), bone ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.10.002
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:"Take the Volume Pledge" proposes restricting pancreatectomies to hospitals that perform ≥20 per year. Our purpose was to identify those factors that characterize patients at risk for loss of access to pancreatic cancer care with enforcement of volume standards. METHODS:Using the Healthcare Cost and Utiliza...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.07.017
更新日期：2017-03-01 00:00:00
abstract：:Myocardial high-energy phosphate and glucose-6-phosphate levels were determined in the in vivo pig heart model during ischemic arrest and reperfusion to determine the effectiveness of potassium cardioplegia in myocardial protection. Thirty-five pigs were divided into six experimental groups consisting of 2-hour normot...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
