Reversal of ischemic damage with amino acid substrate enhancement during reperfusion.

abstract：BACKGROUND:Seeding of vascular grafts with genetically engineered human endothelial cells (hECs) secreting antithrombogenic or fibrinolytic agents has considerable clinical potential. METHODS:An adenoviral vector was used to transfer the human tissue-type plasminogen activator (htPA) gene to hECs, and the ability of t...

journal_title：Surgery

authors： Sugawara Y,Sakata Y,Minowada S,Hamada H,Yoshida Y,Sato O,Deguchi J,Kimura H,Namba T,Makuuchi M,Miyata T

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Pelvic ring fractures (PRFs) are a major cause of morbidity and mortality in motor vehicle collisions (MVCs). Understanding the factors leading to PRFs may help improve vehicle design and safety. This study sought to determine the vehicular, crash, and occupant characteristics that contribute to PRFs. METHO...

journal_title：Surgery

authors： Rowe SA,Sochor MS,Staples KS,Wahl WL,Wang SC

更新日期：2004-10-01 00:00:00

abstract：:The use of a modified bovine collagen graft as a low-pressure conduit was investigated by implantation into the iliocaval system of dogs. In the 210 day observation period, a patency rate of 87.5% was achieved. Nearly all graft failures occured within the first 14 days following implantation; failure after that time d...

journal_title：Surgery

authors： Horsch S,Pichlmaier H,Walter P,Landes T

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND:The Hedgehog (Hh) gene family is known to regulate development of stem cells. In addition, activation is responsible for the induction of GLI1 proto-oncogene and subsequent cellular proliferation. Sonic Hedgehog (SHh), one of the Hh family members promotes carcinogenesis in airway and pancreatic epithelia, i...

journal_title：Surgery

authors： Douard R,Moutereau S,Pernet P,Chimingqi M,Allory Y,Manivet P,Conti M,Vaubourdolle M,Cugnenc PH,Loric S

更新日期：2006-05-01 00:00:00

abstract：:Complete axillary dissection was performed in 287 patients undergoing modified radical mastectomy between 1984 and 1987 to identify patterns of axillary node metastases, as well as discontinuous axillary node ("skip") metastases. Positive pathologic findings were compared with preoperative clinical examinations in 266...

journal_title：Surgery

authors： Chevinsky AH,Ferrara J,James AG,Minton JP,Young D,Farrar WB

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:To assess trainee satisfaction in their surgery residency with a validated instrument and identify the contributing factors. BACKGROUND:Currently, surgery is deemed unattractive by medical students and ignored by many candidates planning to enter an academic career. New insights on the rational for such lack...

journal_title：Surgery

authors： von Websky MW,Oberkofler CE,Rufibach K,Raptis DA,Lehmann K,Hahnloser D,Clavien PA

更新日期：2012-11-01 00:00:00

abstract：:Three cases of peripheral embolism resulting from atheromatous aortic plaques are reported. Although the majority of arterial thromboemboli are believed to have originated from mural thrombi within one of the cardiac chambers, there is reason to believe that embolism from atheromatous material within a major artery ma...

journal_title：Surgery

authors： Kwaan JH,Molen RV,Stemmer EA,Connolly JE

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:Primary hyperparathyroidism is associated with an increased cardiovascular morbidity and mortality. However, mechanisms underlying this association are currently unclear. As there is clear evidence of the independent role of aldosterone on the cardiovascular system, the aim of this study was to evaluate aldo...

journal_title：Surgery

authors： Brunaud L,Germain A,Zarnegar R,Rancier M,Alrasheedi S,Caillard C,Ayav A,Weryha G,Mirallie E,Bresler L

更新日期：2009-12-01 00:00:00

abstract：:Abdominal wall defects created in Sprague-Dawley rats were repaired with either polypropylene mesh (PPM) or expanded polytetrafluoroethylene patch (PTFE). Tensiometric studies of abdominal wall strength showed that PPM and expanded PTFE provided a strong repair in uninfected wounds. Wounds reconstructed with expanded ...

journal_title：Surgery

authors： Law NW,Ellis H

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:No reports have yet precisely determined corticotropin (ACTH) responsiveness in virilizing adrenocortical adenoma. METHODS:Five women with an androgen-secreting adrenal adenoma were reviewed. Three of them were examined by in vitro steroidogenesis. Two of these 3 patients were studied by immunohistochemistr...

journal_title：Surgery

authors： Imai T,Tobinaga J,Morita-Matsuyama T,Kikumori T,Sasano H,Seo H,Funahashi H

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Gram-negative infections are a major cause of morbidity and death. Bactericidal permeability-increasing protein (BPI) is an endotoxin-neutralizing protein that also exhibits potent bactericidal activity. This study compared the efficacy of a 23 kd recombinant N-terminal fragment of BPI (rBPI23) with that of ...

journal_title：Surgery

authors： Kelly CJ,Cech AC,Argenteanu M,Gallagher H,Shou J,Minnard E,Daly JM

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Our aim was to identify differential expression of genes in hepatocellular carcinoma (HCC) with the ultimate goal of discovering novel diagnostic and therapeutic targets. METHODS:We examined differences in gene expression between HCC and noncancerous liver tissue using a cDNA array with probes for 15,843 ge...

journal_title：Surgery

authors： Hua Z,Chen J,Sun B,Zhao G,Zhang Y,Fong Y,Jia Z,Yao L

更新日期：2011-06-01 00:00:00

abstract：:Peripheral parenteral nutrition avoids the use of central lines and is a useful means of nutritional support for selected patients. Amino acids alone have been used for peripheral parenteral nutrition and have been shown to give near nitrogen equilibrium. The addition of small amounts of dextrose to amino acids furthe...

journal_title：Surgery

authors： Fairfull-Smith RJ,Stoski D,Freeman JB

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether nitric oxide regulates insulin secretion in the isolated perfused human pancreas. METHODS:Single-pass perfusion was performed in four pancreata with a modified Krebs medium. Sequential 10-minute infusions (separated by 10-minute basal periods) of (1) 25 nmo...

journal_title：Surgery

authors： Atiya A,Cohen G,Ignarro L,Brunicardi FC

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Obesity is known as a risk factor for intra- and postoperative complications in pancreatic operation. However, the operative outcomes in obese patients undergoing laparoscopic distal pancreatectomy remain unclear. METHODS:A total number of 423 patients underwent laparoscopic distal pancreatectomy at Oslo Un...

journal_title：Surgery

authors： Sahakyan MA,Røsok BI,Kazaryan AM,Barkhatov L,Lai X,Kleive D,Ignjatovic D,Labori KJ,Edwin B

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Pathways critical for neuroblastoma cancer stem cell function are targeted by 4,19,27-triacetyl withalongolide A (WGA-TA). Because neuroblastoma cells and their cancer stem cells highly overexpress the scavenger receptor class B type 1 receptor that binds to synthetic high-density lipoprotein, we hypothesize...

journal_title：Surgery

authors： Subramanian C,White PT,Kuai R,Kalidindi A,Castle VP,Moon JJ,Timmermann BN,Schwendeman A,Cohen MS

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Thermal ablation by radiofrequency or laser is used increasingly for the treatment of colorectal liver metastases. Recurrence after thermal ablation is common and occurs both locally and at distant sites. One possible cause of this recurrence may be a result of growth stimulation of micrometastases in the re...

journal_title：Surgery

authors： Nikfarjam M,Muralidharan V,Christophi C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The management of pancreaticoduodenal endocrine tumors (PETs) remains controversial in multiple endocrine neoplasia type 1 (MEN 1). METHODS:Twenty-one patients with MEN 1 and PETs were analyzed for outcome of surgery and surveillance with special regard to the genotype based on MEN1 gene mutation analysis. ...

journal_title：Surgery

authors： Bartsch DK,Langer P,Wild A,Schilling T,Celik I,Rothmund M,Nies C

更新日期：2000-12-01 00:00:00

abstract：:A rat gastric chamber preparation was used to determine the interrelations between H+ back diffusion, mucosal blood flow, the area of mucosa treated with bile salts and ulcer formation. The rate of H+ back diffusion was found to be dependent on both mucosal blood flow and the area of mucosa exposed to bile salts. It i...

journal_title：Surgery

authors： Mersereau WA,Hinchey EJ

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:Carotid endarterectomy (CEA) reduces the risk of stroke in selected patients with symptomatic and asymptomatic carotid disease, but its beneficial influence on cognitive performance in the elderly remains debatable. This prospective study sought to determine early and long-term neurocognitive outcomes after ...

journal_title：Surgery

authors： Baracchini C,Mazzalai F,Gruppo M,Lorenzetti R,Ermani M,Ballotta E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The connective tissue component hyaluronan is accumulated locally in the damaged tissue during various inflammatory conditions. Owing to the strong water-binding capacity of this glycosaminoglycan, increased tissue content of hyaluronan is paralleled by the development of interstitial edema. The aim with the...

journal_title：Surgery

authors： Johnsson C,Hällgren R,Tufveson G

更新日期：2000-06-01 00:00:00

abstract：:The multiple endocrine neoplasia (MEN) IIb syndrome has been differentiated from MEN IIa by the presence of various phenotypic characteristics such as mucosal neuromas, marfanoid habitus, congenital skeletal anomalies, and prominent corneal nerves, as well as the lack of parathyroid involvement. Analysis of a kindred ...

journal_title：Surgery

authors： Talpos GB,Jackson CE,Yott JB,Van Dyke DL

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Surgical enteral access prior to multimodality treatment for esophageal cancer is controversial as dysphagia is often used for feeding tube referral. We hypothesized that enteral access before neoadjuvant chemoradiation for esophageal cancer provides no benefit compared to that placed during definitive esoph...

journal_title：Surgery

authors： Jenkins TK,Lopez AN,Sarosi GA,Ben-David K,Thomas RM

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Living-donor liver transplantation has become a legitimate alternative to cadaveric liver transplantation. However, information on the perioperative management of donors is still scarce. METHODS:Between October 1996 and May 2001, 52 consecutive living-donor liver transplantations have been performed at the ...

journal_title：Surgery

authors： Soejima Y,Harada N,Shimada M,Suehiro T,Minagawa R,Hiroshige S,Ninomiya M,Shiotani S,Nishizaki T

更新日期：2002-01-01 00:00:00

abstract：:Recent reports demonstrate that culture of thyroid allografts before transplantation results in prolonged and sometimes indefinite survival. The loss of passenger leukocytes during organ culture was discussed as a possible reason for these findings. Recent data from a genetically defined system in the mouse demonstrat...

journal_title：Surgery

authors： Sollinger HW,Burkholder PM,Rasmus WR,Bach FH

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Lung injury is a life-threatening complication in patients with liver dysfunction. We recently provided an experimental lung injury model in mouse with common bile duct ligation. In this study, we aimed to characterize the pathologic and biochemical features of lung tissues in common bile duct ligation mice ...

journal_title：Surgery

authors： Sakaue T,Shikata F,Utsunomiya K,Fukae S,Kurata M,Nakaoka H,Okazaki M,Kawanishi Y,Kojima A,Higashiyama S,Izutani H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:This study examines factors associated with the performance of orthotopic liver transplantation (OLT) without red blood cell (RBC) transfusion. METHODS:Between January 1992 and December 1994, 306 primary OLTs were performed with recipients divided into two groups: group 1 patients (61 recipients, 20% of tot...

journal_title：Surgery

authors： Cacciarelli TV,Keeffe EB,Moore DH,Burns W,Chuljian P,Busque S,Concepcion W,So SK,Esquivel CO

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:This study was conducted to identify the relevant cutoff value and to evaluate the usefulness of postoperative-stimulated serum thyroglobulin (Tg) at the time of (131)I ablation for the prediction of disease status in patients with differentiated thyroid carcinoma (DTC) who received high-dose (131)I ablation...

journal_title：Surgery

authors： Lee JI,Chung YJ,Cho BY,Chong S,Seok JW,Park SJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Little is known about the value of sequential transcatheter arterial chemoembolization and portal vein embolization compared with portal vein embolization alone before major hepatectomy for large hepatocellular carcinoma. We aimed to compare early and long-term outcomes of these two strategies. METHODS:We i...

journal_title：Surgery

authors： Terasawa M,Allard MA,Golse N,Sa Cunha A,Cherqui D,Adam R,Saiura A,Vibert E

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Polymorphonuclear leukocyte (PMN) activation after interaction with implantable surfaces has been previously reported. The purpose of this study was to examine the mechanism of PMN activation in response to expanded polytetrafluoroethylene (ePTFE). METHODS:To demonstrate PMN activation, the cumulative produ...

journal_title：Surgery

authors： Katz DA,Haimovich B,Greco RS

更新日期：1994-08-01 00:00:00