Abstract：
:A rat gastric chamber preparation was used to determine the interrelations between H+ back diffusion, mucosal blood flow, the area of mucosa treated with bile salts and ulcer formation. The rate of H+ back diffusion was found to be dependent on both mucosal blood flow and the area of mucosa exposed to bile salts. It is concluded that, although H+ back diffusion is a convenient measure of barrier permeability under conditions of normal mucosal blood flow, during mucosal ischemia this parameter fails to reflect permeability because of decreased mucosal clearance of H+. These findings would explain apparent controversy whereby ulceration occurs under shock conditions in the absence of apparent H+ back diffusion.
journal_name
Surgeryjournal_title
Surgeryauthors
Mersereau WA,Hinchey EJsubject
Has Abstractpub_date
1978-03-01 00:00:00pages
248-51issue
3eissn
0039-6060issn
1532-7361pii
0039-6060(78)90222-2journal_volume
83pub_type
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