Abstract:
BACKGROUND:Primary hyperparathyroidism is associated with an increased cardiovascular morbidity and mortality. However, mechanisms underlying this association are currently unclear. As there is clear evidence of the independent role of aldosterone on the cardiovascular system, the aim of this study was to evaluate aldosterone levels in patients with primary hyperparathyroidism. METHODS:A prospective study of 134 consecutive patients with primary hyperparathyroidism before and 3 months after parathyroidectomy. RESULTS:Pre-operative serum aldosterone and parathyroid hormone (PTH) levels were correlated positively in all patients (.238; P = .005). In the 62 patients (46%) that were not on antihypertensive medications, this correlation was stronger (.441; P = .0003). In the 72 patients (54%) treated with at least 1 antihypertensive medication, no correlation between preoperative aldosterone and PTH serum levels was observed. By multivariate analysis, pre-operative PTH level (.409; P = .005) was an independent predictor of aldosterone. Pre-operative PTH level >100 ng/L was an independent predictor of abnormally elevated plasma aldosterone level (odds ratio 3.5; P = .01). At 3 months after parathyroidectomy, no correlation was observed between postoperative PTH and aldosterone levels. CONCLUSION:Aldosterone is correlated positively to preoperative PTH levels in patients with primary hyperparathyroidism. Aldosterone might be a key mediator of cardiovascular symptoms in patients with primary hyperparathyroidism.
journal_name
Surgeryjournal_title
Surgeryauthors
Brunaud L,Germain A,Zarnegar R,Rancier M,Alrasheedi S,Caillard C,Ayav A,Weryha G,Mirallie E,Bresler Ldoi
10.1016/j.surg.2009.09.041subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1035-41issue
6eissn
0039-6060issn
1532-7361pii
S0039-6060(09)00693-Xjournal_volume
146pub_type
杂志文章相关文献
SURGERY文献大全abstract::To determine the relative value of carotid phonoangiography (CPA), oculoplethysmography-Kartchner (OPG-K), and Doppler ultrasonic arteriography (UA), 90 vessels undergoing carotid endarterectomy were prospectively examined. By analyzing the data on receiver operator characteristic curves, the dynamic relationship betw...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Tumor-associated lymphatic networks are the primary routes for tumor cell dissemination and metastasis. Behind the background of possible lymphangiogenesis-associated therapies, the clinical impact of lymphangiogenesis (measured by lymphatic microvessel density [LMVD]) and specific lymphovascular invasion (L...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.10.007
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:Rapid thrombelastography (rTEG) has been advocated as a point-of-care test to manage trauma-induced coagulopathy. rTEG activated clotting time (T-ACT) results become available much sooner than other rTEG values, thus offering an attractive tool to guide blood component transfusion in a hemorrhagic shock. W...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.04.017
更新日期:2014-09-01 00:00:00
abstract::Patients with chronic renal failure and total diversion of the lower urinary tract have been considered poor transplant candidates, and post-transplant urinary diversion, i.e., Bricker loop, has been thought to be necessary. Our experience with nine patients clearly indicates that these patients are actually excellent...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::Postendarterectomy platelet deposition and thrombus formation may play an important role not only in vessel wall healing but also in the small incidence of postoperative cerebral ischemia and postoperative stenosis. A study has been performed using a canine model to investigate the healing response to carotid endarter...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Routine central lymph node dissection (CLND) for papillary thyroid cancer (PTC) at the time of initial thyroidectomy has been advocated with a demonstrated decrease in post-ablation serum thyroglobulin compared to total thyroidectomy alone. Patients now present with central compartment metastatic disease aft...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.01.013
更新日期:2009-05-01 00:00:00
abstract::The smuggling of illicit drugs by concealing them within the human body has become a widespread practice. Those individuals who transport packaged drugs are commonly known as "body packers" or "mules". "Body stuffers," on the other hand, are individuals who emergently place the contraband in a body orifice when they s...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared wi...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Common anastomotic complications after pancreatoduodenectomy (PD) are leakage from the pancreaticojejunostomy or hepaticojejunostomy. Leakage from the gastroenteric anastomosis has rarely been described. We evaluated the incidence of gastroenteric leakage after PD and described its presentation, treatment, a...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.03.044
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Parathyroidectomy has a success rate of greater than 95% in the hands of experienced surgeons. To maintain this result in a more cost-effective way, intraoperative monitoring of intact parathyroid hormone (iPTH) has been used to decrease operative times. This technique signals when all hyperfunctioning tissu...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80040-7
更新日期:1996-12-01 00:00:00
abstract::Treatment of rat allograft recipients before grafting with donor spleen cells and whole, pooled antidonor alloimmune serum results in indefinite renal allograft survival. The enhancement is immunologically specific. In these experiments a monoclonal, homogenous anti-BN antibody was produced by a hybridoma clone create...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:The goal of this study was to determine, in lung transplant patients, if laparoscopic antireflux surgery (LARS) is an effective means to prevent aspiration as defined by the presence of pepsin in the bronchoalveolar lavage fluid (BALF). METHODS:Between September 2009 and November 2010, we collected BALF fro...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.07.053
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Minority-serving hospitals have greater readmission rates after operative procedures including colectomy; however, little is known about the contribution of hospital factors to readmission risk and mortality in this setting. This study evaluated the impact of hospital factors on readmissions and inpatient mo...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.08.041
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Somatostatin analogues inhibit peptide release and cell growth through multiple postreceptor signal transduction mechanisms (PRSTM), including G proteins (GP), cyclic adenosine monophosphate (cAMP), calcium, protein kinase C (PKC), and tyrosine phosphatase (TP). Octreotide acetate (OA), a somatostatin analog...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::We report a patient with malignant melanoma metastatic to the supraampullar portion of the common bile duct. The unique aspects of this case include its clinical presentation masquerading as obstructive jaundice caused by a bile duct tumor and the finding of an isolated solitary recurrence metastatic to the bile duct....
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::We studied the role of hypoproteinemia, induced by a major burn injury, on the edema process in burned and nonburned tissues including the lung in the adult sheep. We used lymph flow (QL) and the lymph-plasma (L/P) protein ratio as indicators of the rate of fluid and protein flux across the microcirculation and into t...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-02-01 00:00:00
abstract::Interleukin-2 (IL-2) mediates the regression of metastatic cancer, but clinical application has been limited by the induction of dose-dependent toxicities in normal tissues. The most clinically significant toxicities occur secondary to a vascular leak syndrome and include acute respiratory failure and hemodynamic inst...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:In an attempt to prevent overly aggressive treatment of low-risk thyroid cancers, the American Thyroid Association changed guideline recommendations in late 2015 to state that either hemithyroidectomy or total thyroidectomy are acceptable operations for these patients. We hypothesized that surgeons would inc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.03.002
更新日期:2019-09-01 00:00:00
abstract::Infusion phlebitis is the most common complication of intravenous therapy. Six methods of reducing the incidence of infusion phlebitis including inline final filtration, buffers, heparin, hydrocortisone, heparin-hydrocortisone combinations, and frequent set changes were tested in a two part randomized prospective doub...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1979-04-01 00:00:00
abstract::Eighteen patients with arteriovenous malformations (AVM's) involving the extremities, pelvis, or head are reported and their treatment is discussed. Our experience has led us to the following conclusions: (1) careful selective angiography is mandatory to delineate the vascular anatomy, extent, and major afferent vesse...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Malignant intra-abdominal neuroendocrine tumors are rare; consequently, a standard chemotherapeutic protocol for patients with unresectable disease has not been established. This prompted a review of our experience with dimethyltriazeno imidazole carboxamide (dacarbazine) (DTIC) treatment for these tumors. From 1976 t...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:The existence of primary gastrinomas in lymph nodes continues to be controversial, because distinction from metastases from occult or regressed primary tumors may be difficult to exclude with certainty. If primary nodal gastrinomas do indeed occur, precursor neuroendocrine cells should be identifiable within...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80100-x
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:The role of histocompatibility between donor and recipient in liver transplant rejection is unclear because of a paucity of data. The influence of human leukocyte antigen (HLA) type on immunologic graft loss was examined for primary liver transplantations performed at this center. METHODS:Immunologic graft ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Pancreatic endocrine tumors (PETs) may secrete a variety of peptide hormones, either alone or in combination, and intravenously administered provocative agents have been used to stimulate hormone release to aid in the diagnosis and localization in suspected cases. These features of PETs led us to perform det...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the genotype-phenotype relationship of pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 treated at our institution. METHODS:We conducted a retrospective chart review of all patients with multiple endocrine neoplasia type 1 treated...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.04.044
更新日期:2018-01-01 00:00:00
abstract::Two patient groups were studied to determine the need to preserve the greater saphenous vein during femoral outflow reconstruction for later aortocoronary bypass procedures. First, 74 patients were followed to the time of death or to a minimum of 5 years after femoral outflow reconstruction was performed. Only four pa...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Clinical parameters influencing the effect of preoperative portal vein embolization (PVE) in hypertrophying the nonembolized lobe of patients with either normal or abnormal liver parenchyma and its effect upon portal pressure were examined to identify the patient population for whom this approach is most sui...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2002.118259
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the risk of recurrent laryngeal nerve palsy (RLNP) after thyroidectomy with routine identification of the recurrent laryngeal nerve (RLN) during the operation. METHODS:The present study was confined to 521 patients, 348 total lobectomies and 178 total thyroidectomies, tre...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.09.008
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Very late activation-2 (VLA-2) is an integrin receptor for laminin that consists of an alpha 2- and a beta 1-subunit. In human breast cancer, down-regulation of VLA-2 expression is related to positive nodal status. The functional significance of altered integrin expression in individual patients has never be...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80330-7
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Laparoscopic techniques are being used increasingly in the repair of ventral hernias and offer the potential benefits of a shorter hospital stay, decreased wound complications, and possibly a lower recurrence rate. Despite good results from high-volume centers, significant complications may occur with this a...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.06.054
更新日期:2005-10-01 00:00:00