Abstract:
BACKGROUND:The existence of primary gastrinomas in lymph nodes continues to be controversial, because distinction from metastases from occult or regressed primary tumors may be difficult to exclude with certainty. If primary nodal gastrinomas do indeed occur, precursor neuroendocrine cells should be identifiable within lymph nodes. In a effort to detect these cells we undertook an immunohistochemical survey of regional pancreatic lymph nodes by using antibody against chromogranin, a highly specific marker for mature neuroendocrine cells. METHODS:We retrospectively identified consecutive cases from five surgeons in which Whipple resections had been performed for nonendocrine pathologic conditions. All formalin-fixed, paraffin-embedded lymph nodes were identified from these 106 cases, excluding lymph nodes with metastases. Immunoperoxidase staining with monoclonal antibody against chromogranin A was performed on single tissue sections. All slides were reviewed by a single pathologist; chromogranin-positive cells were identified and, when possible, further evaluated immunohistochemically with additional neuroendocrine markers, including sequential synaptophysin staining. RESULTS:A total of 1026 lymph nodes were available for review. Although well-formed intranodal chromogranin-positive nests were not identified, six nodes from three patients contained 13 strongly chromogranin-positive cells representing putative neuroendocrine cells. Mast cells showed weak nonspecific staining with chromogranin but were morphologically distinct. Perinodal adipose tissue contained a single paraganglion and several small neuroendocrine clusters. CONCLUSIONS:Putative neuroendocrine cells are rarely (less than 1%) found in regional pancreatic lymph nodes. Although these may be embryonic rests and might represent precursors of primary nodal gastrinomas, specific hormones have yet to be identified in these cells. Although these data provide support for the concept of primary nodal gastrinomas, this remains a diagnosis of exclusion.
journal_name
Surgeryjournal_title
Surgeryauthors
Perrier ND,Batts KP,Thompson GB,Grant CS,Plummer TBdoi
10.1016/s0039-6060(05)80100-xsubject
Has Abstractpub_date
1995-12-01 00:00:00pages
957-65; discussion 965-6issue
6eissn
0039-6060issn
1532-7361pii
S0039-6060(05)80100-Xjournal_volume
118pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) promotes tumor angioinvasion while VEGF-C is a potent lymphangiogenic factor. This study aims at evaluating serum VEGF (sVEGF) and sVEGF-C levels in recurrent papillary thyroid carcinoma (PTC) patients. METHODS:Serum samples were collected preoperatively from 85 pat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.07.027
更新日期:2008-12-01 00:00:00
abstract:INTRODUCTION:There is a paucity of data on outcomes for lung transplant (LT) recipients requiring general surgery procedures. This study examined outcomes after cholecystectomy in LT recipients using a large database. METHODS:The National Inpatient Sample Database (2005-2010) was queried for all LT patients requiring ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.02.021
更新日期:2015-08-01 00:00:00
abstract::An expandable intraluminal graft mounted coaxially over an angioplasty balloon catheter was used in dog arteries. The graft, a wire mesh tube that has the ability to retain its expanded shape, opposes elastic recoil of the arterial wall after maximum balloon inflation. Eighteen grafts were placed in the abdominal aort...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Several studies have demonstrated that postoperative complications after pancreatectomy for pancreatic cancer adversely affect survival. The impact on survival of a pancreatic fistula according to the classification of the International Study Group for Pancreatic Surgery has not been fully evaluated. The aim...
journal_title:Surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.surg.2016.02.032
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Activated factor X (FXa) is involved in hemostasis, thrombogenesis, inflammation, and cellular immune response. Tissue factor (TF) is an initiator of blood coagulation. We investigated whether FXa induces TF expression in human peripheral monocytes and whether treatment with FXa inhibitor reduces TF expressi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2001.116452
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:To clarify the biologic behavior of the early signet-ring cell cancers (SRCs) by comparing the clinicopathologic features and the incidence of lymph node metastasis between different histologic types of early gastric cancer (EGC) and to propose the indications of endoscopic surgery for SRCs. METHODS:Clinico...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.07.006
更新日期:2011-03-01 00:00:00
abstract::Fine-needle aspirations and cutting needle biopsies were performed on 415 patients with solitary thyroid nodules. All nodules were considered hypofunctioning by scintiscans. Specimens were adequate in 399 patients. Ten percent of these patients had thyroid cancers documented by thyroidectomies. Results from either or ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::The use of a modified bovine collagen graft as a low-pressure conduit was investigated by implantation into the iliocaval system of dogs. In the 210 day observation period, a patency rate of 87.5% was achieved. Nearly all graft failures occured within the first 14 days following implantation; failure after that time d...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Although prophylactic glucocorticoids have been used before liver resection to minimize liver dysfunction, it is unknown whether treatment with glucocorticoids will accelerates recovery from hyperbilirubinemia after liver resection. METHODS:In this open-label, randomized, controlled trial, patients with hyp...
journal_title:Surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.surg.2018.09.002
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Medullary carcinoma of the thyroid gland (MCT) is a disease commonly associated with regional metastases. Apart from surgical resection, there are limited therapeutic options for such patients. Given the variable and often prolonged survival of such patients, the benefit of surgical resection is difficult to...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::A case report of a patient with Marfan's syndrome who developed acute supravalvular aortic stenosis following aortic valve replacement and reconstruction of the ascending aorta is presented. Early recognition of this complication permitted reoperation and successful repair. One similar case has been reported previousl...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Measuring patient work of breathing (WOBpt) has been suggested to provide safe, aggressive weaning from mechanical ventilation. We compared WOBpt and pressure-time-product (PTP) to routine weaning parameters [breath rate (f), tidal volume (VT), frequency/tidal volume ratio (f/VT)] at different levels of pres...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0039-6060(97)90081-7
更新日期:1997-10-01 00:00:00
abstract::In pigs subtotal ischemic liver cell necrosis was induced 4 days after auxiliary transplantation of 60% of the liver of an MLC-compatible donor (ATPL group, n = 13). In control animals (n = 14) temporary liver ischemia was preceded by division of the hepatic ligaments and creation of an end-to-side portacaval shunt. I...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Since November 1992, operative repair in neonates with congenital diaphragmatic hernia (CDH) at this institution was delayed until respiratory insufficiency had resolved. METHODS:A retrospective analysis was performed (n = 33) comparing delayed repair with our previously reported institutional experience wi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80029-8
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Limited data exist regarding the downstream effects of surgical transitional care programs. We explored the impact of such programs on patient satisfaction and fiscal metrics. METHODS:A telephone-based surgical transitional care program enrolled patients undergoing complex abdominal surgery between 2015 to ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.09.015
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Sclerotherapy is usually effective in controlling acutely bleeding esophageal varices. It may not be as effective as shunt surgery for prevention of rebleeding; therefore we undertook a prospective study comparing interposition mesocaval shunt (MCS) and repeated sclerotherapy. METHODS:Forty-five patients (m...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0039-6060(05)80248-x
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Ischemia and reperfusion (I/R) injury is a major determinant of early graft dysfunction and long-term graft survival in small intestinal transplantation. The cavitary two-layer method (TLM) has been reported to be superior to the University of Wisconsin cold storage method (UWM) in long-term preservation of ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2003.10.013
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:It has been shown that vagal nerve stimulation (VNS) can affect body mass. The aim of this study was to evaluate effect of VNS on body mass, body composition, metabolic rate, and plasma leptin and IGF-I levels. METHODS:Eight female pigs were included in the study. Under general anesthesia, a bipolar electro...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.06.025
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Ventral abdominal wall hernias are common lesions and may be associated with life-threatening complications. The application of laparoscopic principles to the treatment of ventral hernias has reduced recurrence rates from a range of 25% to 52% to a range of 3.4% to 9%. In this study, we review our experience...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(03)00283-6
更新日期:2003-10-01 00:00:00
abstract::Bupivacaine wound infiltration together with efficient esophagogastric decompression and immediate elemental feeding in 43 consecutive, well-instructed patients who had undergone cholecystectomy reduced their postoperative analgesia requirements to an average of 17 (+/- 46, SD) mg of meperidine during the initial 24 h...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract::We reviewed 137 patients with colon injury and applied multiple regression analysis to determine the influence of various parameters on colon-related infection. The complications of intra-abdominal abscess, wound infection, and peristomal abscess occurred in 25% of patients. The mortality rate was 3.6%, and four of fi...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::Using software to transform magnetic resonance imaging (MRI) tomographic data into three-dimensional projections, we have produced "angiograms" of the abdominal aorta in 18 patients with occlusive (15) and aneurysmal (3) disease. This information may be displayed to demonstrate flow, cross-sectional diameter, or aorti...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Nosocomial pneumonia (NP) in injured patients is a significant clinical problem. We hypothesize that the pathogenesis of NP in injured patients involves an imbalanced cytokine response within the alveolar airspace that may inhibit effector cell function. METHODS:Proinflammatory (IL-8) and anti-inflammatory ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2001.117105
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:The long-term outcome of bilateral adrenalectomy in the management of patients with Cushing's syndrome has not been previously well studied. METHODS:We reviewed our long-term results in 34 patients treated with bilateral adrenalectomy between 1983 and the present. Fourteen presented with occult or metastati...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. METHODS:Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Orga...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.04.039
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Surgery for pancreatic necrosis is associated with a high morbidity and mortality. The aim of this study was to review the incidence of early and late complications after pancreatic necrosectomy in a large contemporary series of patients. METHODS:The clinical outcomes of 88 patients who underwent pancreatic...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.01.003
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Encapsulated follicular variant of papillary thyroid carcinoma has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the basis of its highly indolent behavior, as proposed by an international group of experienced thyroid pathologists. METHODS:All p...
journal_title:Surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.surg.2018.04.089
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The process of extrinsic reinnervation after small bowel transplantation is poorly understood. METHODS:Jejunal and ileal specimens, obtained from the dogs that underwent intestinal autotransplantation by an end-to end (E-E) or end-to-side arterial reconstruction, were analyzed at 1 (n = 7), 3 (n = 6), 6 (n ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The hydrogen gas clearance technique was evaluated to estimate regional hepatic blood flow. Initially, the H2 gas method was compared to the indocyanine green clearance in mini pigs. The blood flow measured by the H2 gas method (0.49 +/- 0.03 ml/min/gm) was only 39% of the calculated blood flow by the indocyanine gree...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract::Endothelial cell (EC) seeding has been proposed as a method to improve the performance of small-caliber synthetic vascular prostheses. Seeding experiments to date have all been carried out in the dog. This study investigates EC seeding of small-caliber Dacron carotid interposition grafts compared with contralateral co...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00