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The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation.

Abstract：

BACKGROUND:The goal of this study was to determine, in lung transplant patients, if laparoscopic antireflux surgery (LARS) is an effective means to prevent aspiration as defined by the presence of pepsin in the bronchoalveolar lavage fluid (BALF). METHODS:Between September 2009 and November 2010, we collected BALF from 64 lung transplant patients at multiple routine surveillance assessments for acute cellular rejection, or when clinically indicated for diagnostic purposes. The BALF was tested for pepsin by enzyme-linked immunosorbent assay (ELISA). We then compared pepsin concentrations in the BALF of healthy controls (n = 11) and lung transplant patients with and without gastroesophageal reflux disease (GERD) on pH-monitoring (n = 8 and n = 12, respectively), and after treatment of GERD by LARS (n = 19). Time to the development of bronchiolitis obliterans syndrome was contrasted between groups based on GERD status or the presence of pepsin in the BALF. RESULTS:We found that lung transplant patients with GERD had more pepsin in their BALF than lung transplant patients who underwent LARS (P = .029), and that pepsin was undetectable in the BALF of controls. Moreover, those with more pepsin had quicker progression to BOS and more acute rejection episodes. CONCLUSION:This study compared pepsin in the BALF from lung transplant patients with and without LARS. Our data show that: (1) the detection of pepsin in the BALF proves aspiration because it is not present in healthy volunteers, and (2) LARS appears effective as a measure to prevent the aspiration of gastroesophageal refluxate in the lung transplant population. We believe that these findings provide a mechanism for those studies suggesting that LARS may prevent nonallogenic injury to the transplanted lungs from aspiration of gastroesophageal contents.

journal_name

Surgery

journal_title

Surgery

authors

Fisichella PM,Davis CS,Lundberg PW,Lowery E,Burnham EL,Alex CG,Ramirez L,Pelletiere K,Love RB,Kuo PC,Kovacs EJ

doi

10.1016/j.surg.2011.07.053

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

598-606

issue

4

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(11)00404-1

journal_volume

150

pub_type

杂志文章

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