Abstract:
BACKGROUND:There is not enough evidence to establish an appropriate surveillance strategy after operative resection for intraductal papillary mucinous neoplasm. METHODS:This study included 257 consecutive intraductal papillary mucinous neoplasm patients who underwent operative resection between July 1999 and March 2014. The frequencies, patterns, time-to-event, and risk factors for postoperative recurrence in intraductal papillary mucinous neoplasm were analyzed. RESULTS:Fifty-six intraductal papillary mucinous neoplasm patients (21.8%) had recurrence after the operation, including those with remnant pancreatic recurrence (n = 14) and extrapancreatic recurrence (n = 42). Remnant pancreatic recurrence had no influence on the overall survival, whereas patients with extrapancreatic recurrence had significantly worse overall survival (P < .001). Furthermore, the overall survival of intraductal papillary mucinous neoplasm patients with extrapancreatic recurrence was shorter than that for patients with remnant pancreatic recurrence (median overall survival: 21.8 versus 110.6 months; P < .001). Five patients experienced remnant pancreatic recurrence >5 years after the operation. All extrapancreatic recurrences occurred within 5 years. We found that the positive pancreatic transection margin was the only independent risk factor for remnant pancreatic recurrence (P < .001), whereas the risk factors for extrapancreatic recurrence were invasive intraductal papillary mucinous neoplasm (P < .001), mixed-type (P = .008), elevated serum CA19-9 (P = .019), and intraoperative transfusion (P = .025) in the multivariate analysis. CONCLUSION:Our data suggest that all intraductal papillary mucinous neoplasm patients should be subject to continual surveillance every 6 months for >5 years after operation to evaluate the remnant pancreatic recurrence; furthermore, the data indicate that strict 5-year surveillance, including every 3 months for 1 year after the operation and every 6 months thereafter, is necessary for intraductal papillary mucinous neoplasm patients at risk for extrapancreatic recurrence.
journal_name
Surgeryjournal_title
Surgeryauthors
Hirono S,Kawai M,Okada K,Miyazawa M,Shimizu A,Kitahata Y,Ueno M,Yanagisawa A,Yamaue Hdoi
10.1016/j.surg.2016.04.007subject
Has Abstractpub_date
2016-08-01 00:00:00pages
306-17issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(16)30038-1journal_volume
160pub_type
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