当前位置： SCI文献检索 > SURGERY期刊下所有文献 > Effect of surgical margin width after R0 resection for intrahepatic cholangiocarcinoma: A nationwide survey of the Liver Cancer Study Group of Japan.

Effect of surgical margin width after R0 resection for intrahepatic cholangiocarcinoma: A nationwide survey of the Liver Cancer Study Group of Japan.

Abstract：

BACKGROUND:Data are inconsistent regarding the effects of a wide surgical margin for intrahepatic cholangiocarcinoma on recurrence-free survival and overall survival. This study was performed to investigate the effect of surgical margin width in patients undergoing R0 resection for intrahepatic cholangiocarcinoma, using a nationwide database in Japan. METHODS:In total, 635 patients with intrahepatic cholangiocarcinoma who were treated by an R0 resection from 2000 to 2007 were identified from the database of a Japanese nationwide survey. Patients were divided into quartiles of the surgical margin width as follows: marginal (<1 mm), narrow (1-4 mm), intermediate (5-9 mm), and wide groups (≥10 mm). Multivariable Cox regression models for recurrence-free survival and overall survival were constructed with adjustment for preoperative and postoperative clinicopathologic factors. RESULTS:Compared with the marginal group, the risk-adjusted hazard ratios (95% confidence intervals) in the narrow, intermediate, and wide groups for recurrence-free survival were 0.92 (0.62-1.37), 0.91 (0.61-1.37), and 0.81 (0.56-1.17), and those for overall survival were 0.79 (0.51-1.24), 0.93 (0.59-1.47), and 0.70 (0.46-1.08), respectively. In 398 patients without lymph node metastasis, the hazard ratios for overall survival were 0.62 (0.34-1.11), 0.63 (0.34-1.17), and 0.51 (0.29-0.90), and those of mass-forming type intrahepatic cholangiocarcinoma were 0.48 (0.21-1.08), 0.43 (0.19-0.96), and 0.40 (0.19-0.82), respectively. CONCLUSION:Surgical margin width appears to have a limited effect on the prognosis of intrahepatic cholangiocarcinoma except in patients without lymph node metastasis, where a wide surgical margin is associated with favorable outcomes. This survival benefit of a wide surgical margin is especially apparent for the mass-forming type intrahepatic cholangiocarcinoma.

journal_name

Surgery

journal_title

Surgery

authors

Watanabe Y,Matsuyama Y,Izumi N,Kubo S,Kokudo N,Sakamoto M,Shiina S,Takayama T,Nakashima O,Kudo M

doi

10.1016/j.surg.2019.12.009

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

793-802

issue

5

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(19)30827-X

journal_volume

167

pub_type

杂志文章

相关文献

SURGERY文献大全
  • Topical flurbiprofen decreases burn wound-induced hypermetabolism and systemic lipid peroxidation.

    abstract：:We studied the effect of the topical application of the nonsteroidal anti-inflammatory agent, flurbiprofen, on postburn hypermetabolism and systemic lipid peroxidation. Twelve sheep with a 15% total body surface third-degree burn were monitored over a 4-day postburn period. In six sheep, a single application of a 5% f...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： LaLonde C,Knox J,Daryani R,Zhu DG,Demling RH,Neumann M

    更新日期：1991-05-01 00:00:00

  • Surgical completeness of bilateral axillo-breast approach robotic thyroidectomy: comparison with conventional open thyroidectomy after propensity score matching.

    abstract：BACKGROUND:Bilateral axillo-breast approach (BABA) robotic thyroidectomy (RoT) has good postoperative and excellent cosmetic outcomes. To assess the surgical completeness of BABA RoT, it was compared to open thyroidectomy (OT) after propensity score matching of the cohorts. METHODS:Between 2008 and 2010, 760 patients ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2011.09.015

    authors： Lee KE,Koo do H,Im HJ,Park SK,Choi JY,Paeng JC,Chung JK,Oh SK,Youn YK

    更新日期：2011-12-01 00:00:00

  • Prospective evaluation of clinical and pathologic detection of axillary metastases in patients with carcinoma of the breast.

    abstract：:Complete axillary dissection was performed in 287 patients undergoing modified radical mastectomy between 1984 and 1987 to identify patterns of axillary node metastases, as well as discontinuous axillary node ("skip") metastases. Positive pathologic findings were compared with preoperative clinical examinations in 266...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Chevinsky AH,Ferrara J,James AG,Minton JP,Young D,Farrar WB

    更新日期：1990-10-01 00:00:00

  • The use of the Jarvik-7 total artificial heart and the Symbion ventricular assist device as a bridge to transplantation.

    abstract：:The proliferation of transplantation programs has not been paralleled by a similar increase in the availability of organ donors. Between 1984 and 1987, 104 orthotopic heart transplantations were performed at Loyola University Medical Center. During the same period, 25 patients died while awaiting a donor organ. To red...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Pifarre R,Sullivan HJ,Montoya A,Bakhos M,Grieco J,Foy BK,Blakeman B,Costanzo-Nordin MR,Altergott R,Lonchyna V

    更新日期：1990-10-01 00:00:00

  • Hepatic insufficiency after portacaval shunting is prevented by prior intraportal pancreatic islet autotransplantation.

    abstract：:The extrahepatic diversion of essential splanchnic hepatotrophic factors may cause the liver atrophy and insufficiency that follows portacaval shunting. To investigate this, control dogs with end-to-side portacaval shunts (control-PCS, n = 6) were compared with dogs shunted 1 month after intraportal pancreatic islet a...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Callery MP,Ricordi C,Scharp DW,Kamei T,Swanson CJ,Lacy PE,Flye MW

    更新日期：1989-08-01 00:00:00

  • Cost of surgery in a low-income setting in eastern Uganda.

    abstract：BACKGROUND:Operative interventions have traditionally been seen as expensive; therefore, surgery has been given low priority in global health care planning in low-income countries. A growing body of evidence indicates that surgery can also be highly cost effective in low-income settings, but our current knowledge of th...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2015.01.026

    authors： Löfgren J,Mulowooza J,Nordin P,Wladis A,Forsberg BC

    更新日期：2015-06-01 00:00:00

  • Is genetic screening indicated in apparently sporadic pheochromocytomas and paragangliomas?

    abstract：BACKGROUND:Pheochromocytoma (Pheo) is usually considered a sporadic disease. Recently, an increasing rate of genetically based tumors has been reported. However, the need for systematic screening of unsuspected germline mutations in apparently sporadic forms is still debated. This study aimed to assess the effective ra...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2011.09.024

    authors： Iacobone M,Schiavi F,Bottussi M,Taschin E,Bobisse S,Fassina A,Opocher G,Favia G

    更新日期：2011-12-01 00:00:00

  • Fluid resuscitation with deferoxamine hetastarch complex attenuates the lung and systemic response to smoke inhalation.

    abstract：BACKGROUND:We determined the effect of infusing the iron chelator deferoxamine complexed to hetastarch on the degree of lung dysfunction and systemic abnormalities produced by a severe smoke exposure. METHODS:Adult sheep were given a smoke exposure under anesthesia that produced a peak carboxyhemoglobin between 40% an...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/s0039-6060(96)80121-8

    authors： Demling R,LaLonde C,Ikegami K

    更新日期：1996-03-01 00:00:00

  • Prevention by whole pancreas transplantation of glomerular basement membrane thickening in alloxan diabetes.

    abstract：:Serial thickness measurements of the glomerular basement membrane were performed over a 24-month period in four groups of inbred male Lewis rats. Group I consisted of normal animals age-matched to the remaining experimental groups. In groups II, III, and IV, diabetes was induced by intravenous alloxan (42 to 44 mg/kg)...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Bell RH,Fernandez-Cruz L,Brimm JE,Sayers HA,Lee S,Orloff MJ

    更新日期：1980-07-01 00:00:00

  • Esophageal motility: effects of injection sclerotherapy.

    abstract：:The purpose of this project was to evaluate the acute and chronic effects of sclerotherapy on esophageal motility and function. We studied motility in eight patients before and after injection sclerotherapy of esophageal varices. We injected the varices with 5% sodium morrhuate twice during the first week and then at ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Larson GM,Vandertoll DJ,Netscher DT,Polk HC Jr

    更新日期：1984-10-01 00:00:00

  • The role of altered extrahepatic biliary function in the pathogenesis of gallstones after vagotomy.

    abstract：:Several clinical studies have documented an increased incidence of gallstones after truncal vagotomy. Previous laboratory studies, however, have failed to establish a clear mechanism for this phenomenon. Whereas lithogenic bile is a prerequisite for cholesterol cholelithiasis, gallbladder stasis has also been shown to...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Pitt HA,Doty JE,Roslyn JJ,DenBesten L

    更新日期：1981-08-01 00:00:00

  • Prognostic factors for poor survival after repeat hepatectomy in patients with colorectal liver metastases.

    abstract：BACKGROUND:The recurrence rate for colorectal liver metastases after repeat hepatic resection is high, and selection criteria for repeat hepatectomy are still controversial. METHODS:Clinical data of patients undergoing repeat hepatectomy for metastatic colon cancer were reviewed retrospectively and compared with those...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1067/msy.2003.151

    authors： Takahashi S,Inoue K,Konishi M,Nakagouri T,Kinoshita T

    更新日期：2003-06-01 00:00:00

  • Chronic extrinsic denervation after small bowel transplantation in rat jejunum: Effects and adaptation in nitrergic and non-nitrergic neuromuscular inhibitory mechanisms.

    abstract：BACKGROUND:Extrinsic denervation of the transplanted small bowel could play a substantial role in motor dysfunction of the transplanted gut. We attempted to determine the effect of chronic extrinsic denervation on intestinal contractility. METHODS:Jejunal longitudinal muscle strips were obtained from rats 1 week and 8...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1067/msy.2001.112070

    authors： Balsiger BM,Ohtani N,Anding WJ,Duenes JA,Sarr MG

    更新日期：2001-04-01 00:00:00

  • Vascular graft infection: an analysis of sixty-two graft infections in 2411 consecutively implanted synthetic vascular grafts.

    abstract：:Among 2411 consecutive arterial reconstructions performed with synthetic prosthetic material in Denmark during a 4-year period, 62 patients (2.6%) developed graft infection. Graft infection occurred only when the groin had been incised. The incidence of infection and the spread of infection along the graft did not rel...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Lorentzen JE,Nielsen OM,Arendrup H,Kimose HH,Bille S,Andersen J,Jensen CH,Jacobsen F,Røder OC

    更新日期：1985-07-01 00:00:00

  • Age, poverty, acculturation, and gastric cancer.

    abstract：BACKGROUND:Gastric cancer is an aggressive disease, and overall changes in incidence rates have been noted. There are conflicting data on whether young patients have worse outcomes than older patients; the roles of tumor biology and access to care are critical to answering this question. Our objectives were to explore ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2013.05.017

    authors： Nguyen DK,Maggard-Gibbons M

    更新日期：2013-09-01 00:00:00

  • A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer.

    abstract：BACKGROUND:The role of routine central lymph node dissection (CLND) for papillary thyroid cancer (PTC) remains controversial. The aim of this study was to evaluate the impact of routine CLND after total thyroidectomy (TTx) in the management of patients with PTC who were clinically node negative at presentation with emp...

    journal_title：Surgery

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.surg.2011.09.003

    authors： Popadich A,Levin O,Lee JC,Smooke-Praw S,Ro K,Fazel M,Arora A,Tolley NS,Palazzo F,Learoyd DL,Sidhu S,Delbridge L,Sywak M,Yeh MW

    更新日期：2011-12-01 00:00:00

  • Development of reproducible histologic injury severity scores: skeletal muscle reperfusion injury.

    abstract：BACKGROUND:Ischemia-reperfusion injury of skeletal muscle is a common clinical and experimental problem. To date, there has been no uniform and reproducible method to assess the extent of histologic injury. In this study, we developed a novel statistical methodology for evaluating injury in individual myocytes and 3 di...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2007.06.005

    authors： McCormack MC,Kwon E,Eberlin KR,Randolph M,Friend DS,Thomas AC,Watkins MT,Austen WG Jr

    更新日期：2008-01-01 00:00:00

  • Practicality of using galvanic skin response to measure intraoperative physiologic autonomic activation in operating room team members.

    abstract：BACKGROUND:Physiologic and psychological stress are commonly experienced by operating room (OR) personnel, yet there is little research about the stress levels in OR teams and their impact on performance. Previously published procedures to measure physiologic activation are invasive and impractical for the OR. The purp...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2015.04.009

    authors： Phitayakorn R,Minehart RD,Pian-Smith MC,Hemingway MW,Petrusa ER

    更新日期：2015-11-01 00:00:00

  • The surgical treatment of superficial thrombophlebitis.

    abstract：:Of 3,941 patients who underwent varicose vein surgery from 1968 through 1978, 163 had superficial thrombophlebitis, a common complication of varicose veins. Superficial thrombophlebitis was more frequently found in the older age groups. The incidence of occurrence (three women to one man) was identical to that of the ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Lofgren EP,Lofgren KA

    更新日期：1981-07-01 00:00:00

  • Reverse electrical pacing improves intestinal absorption and transit time.

    abstract：:This study evaluates the effect of reverse electrical pacing on intestinal absorption and transit time in an enterostomy model. Twenty-five male Sprague-Dawley rats (148 to 208 gm) underwent division and anastomosis of the proximal jejunum to eliminate the proximal gastroduodenal pacemaker. A 30.0 cm loop ileostomy wa...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Sawchuk A,Nogami W,Goto S,Yount J,Grosfeld JA,Lohmuller J,Grosfeld MD,Grosfeld JL

    更新日期：1986-08-01 00:00:00

  • Interventions in atherosclerosis: a review for surgeons.

    abstract：:For the surgeon, atherosclerosis is defined by a variety of aneurysmal, occlusive, or ulcerated lesions in major arteries. These end-stage lesions often require operative treatment. However, just as advanced atherosclerosis presents complex clinical phenomena, so its earlier stages display many underlying mechanisms p...

    journal_title：Surgery

    pub_type： 杂志文章,评审

    doi：

    authors： DePalma RG,Clowes AW

    更新日期：1978-08-01 00:00:00

  • Effects of lumbar sympathectomy on canine transcutaneous oxygen tension.

    abstract：:Augmentation of cutaneous blood flow by postganglionic lumbar sympathectomy may not reflect an increase in nutritive vascular supply to the dermal tissues. Transcutaneous oxygen tension (TcPO2) was compared with radionuclide microsphere determination of dermal microcirculation in a hind limb sympathectomy model in 20 ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Brothers TE,Wakefield TW,Jacobs LA,Lindenauer SM

    更新日期：1993-04-01 00:00:00

  • Role of myofibroblasts in pseudointima formation.

    abstract：:Twenty Dacron grafts (10 crimped and 10 noncrimped) were studied with light microscopy, scanning electron microscopy, and transmission electron microscopy (TEM) 1 to 10 months after insertion into the canine thoracoabdominal aorta. Fibroblast-derived pseudointima maintained a smooth luminal lining that approximated th...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Sottiurai VS,Batson RC

    更新日期：1983-11-01 00:00:00

  • Palliative care and active disease management are synergistic in modern surgical oncology.

    abstract：:Palliative care has long been described in medical literature but only recently is being discussed in the surgical domain. Mounting evidence suggests that early integration of palliative care improves patient outcomes and this is especially true of oncology patients. Thus, the pendulum is swinging toward recognizing t...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2017.10.001

    authors： Sadler EM,Hawley PH,Easson AM

    更新日期：2018-04-01 00:00:00

  • Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome.

    abstract：BACKGROUND:The development of liver failure significantly influences prognosis during the course of major septic complications. Although the underlying cause for septic liver failure is still unclear, research using animal models has demonstrated that an increased nitric oxide (NO) synthesis compromises detoxification ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2006.08.011

    authors： Novotny AR,Emmanuel K,Maier S,Westerholt A,Weighardt H,Stadler J,Bartels H,Schwaiger M,Siewert JR,Holzmann B,Heidecke CD

    更新日期：2007-03-01 00:00:00

  • Is a diverting ostomy needed in mid-high rectal cancer patients undergoing a low anterior resection after neoadjuvant chemoradiation? An NSQIP analysis.

    abstract：INTRODUCTION:A diverting stoma is often performed at the time of low anterior resection (LAR) for rectal cancer after neoadjuvant chemoradiation (nCRT) to protect the anastomosis. The aim of this study was to compare surgical outcomes in large cohorts of mid-high rectal cancer patients undergoing LAR after nCRT with an...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2015.02.026

    authors： Messaris E,Connelly TM,Kulaylat AN,Miller J,Gusani NJ,Ortenzi G,Wong J,Bhayani N

    更新日期：2015-09-01 00:00:00

  • Effects of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model.

    abstract：BACKGROUND AND AIMS:Laparoscopic surgery for colorectal cancer is currently being evaluated in humans. The aim of this study was to examine the effect of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model. We also examined the effect of combining laparotomy with laparoscopy and on inf...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1067/msy.1999.99056

    authors： Dorrance HR,Oien K,O'Dwyer PJ

    更新日期：1999-07-01 00:00:00

  • Cutaneous malignant melanoma: current views on pathogenesis, diagnosis, and surgical management.

    abstract：:Reliable cancer statistics reveal an unexplained increase in the incidence and rate of death from melanoma. Increased exposure to ultraviolet light does not seem to be a factor. Hormones may affect the incidence but do not influence survival. The recognition of the biologic evolution of different types of melanomas an...

    journal_title：Surgery

    pub_type： 杂志文章,评审

    doi：

    authors： Adam YG,Efron G

    更新日期：1983-04-01 00:00:00

  • Improved outcome of adult blunt splenic injury: a cohort analysis.

    abstract：BACKGROUND:The purpose of this study was to review our 15-year experience in the treatment of blunt splenic injury in adults. Our hypothesis was that the implementation of a change in practice, with stress on splenic preservation and splenic artery embolization for the management of splenic injury, would result in impr...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2006.07.005

    authors： Rajani RR,Claridge JA,Yowler CJ,Patrick P,Wiant A,Summers JI,McDonald AA,Como JJ,Malangoni MA

    更新日期：2006-10-01 00:00:00

  • Thyroid carcinoma in Graves' disease.

    abstract：:The prevailing hypothesis of thyroid carcinogenesis is that thyroid-stimulating hormone (TSH) is a prime factor in the growth and possibly the genesis of thyroid carcinoma. On the other hand, Graves' disease is a hyperthyroid state caused presumably by human thyroid-stimulating immunoglobulin (HTSI), not TSH. However,...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Farbota LM,Calandra DB,Lawrence AM,Paloyan E

    更新日期：1985-12-01 00:00:00