Abstract：
:The prevailing hypothesis of thyroid carcinogenesis is that thyroid-stimulating hormone (TSH) is a prime factor in the growth and possibly the genesis of thyroid carcinoma. On the other hand, Graves' disease is a hyperthyroid state caused presumably by human thyroid-stimulating immunoglobulin (HTSI), not TSH. However, the literature does contain scattered reports of an association between Graves' disease and thyroid carcinoma. With this background, we retrospectively reviewed our series of 117 consecutive patients operated on for Graves' disease from 1961 through 1984. The series contains 23 male and 94 female patients, with a mean age of 26.3 years at operation (median 26 years; range 8 to 58 years). Of these patients, six (two males and four females) were found to have carcinoma, four papillary and two follicular, for an incidence of 5.1%. Four of the 117 patients had a history of head and neck irradiation; two (50%) subsequently developed carcinoma. For the six patients with carcinoma, mean follow-up has been 8.1 years (median 8 years; range 1 to 14 years). To date there have been no recurrences of carcinoma, and all six are alive and well. Thus our series shows a carcinoma rate of 5.1% in patients with Graves' disease, which is markedly higher than the 0.1% to 0.2% incidence in random autopsy series of all patients. This raises the question of a possible carcinogenic role for HTSI, similar to that hypothesized for TSH, in patients with presumably suppressed TSH.
journal_name
Surgeryjournal_title
Surgeryauthors
Farbota LM,Calandra DB,Lawrence AM,Paloyan Esubject
Has Abstractpub_date
1985-12-01 00:00:00pages
1148-53issue
6eissn
0039-6060issn
1532-7361journal_volume
98pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:Ventral abdominal wall hernias are common lesions and may be associated with life-threatening complications. The application of laparoscopic principles to the treatment of ventral hernias has reduced recurrence rates from a range of 25% to 52% to a range of 3.4% to 9%. In this study, we review our experience...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(03)00283-6
更新日期：2003-10-01 00:00:00
abstract：:Minced adult human, rat, and dog pancreatic fragments were cultured under various conditions in an attempt to selectively purify pancreatic islet tissue from exocrine digestive enzymes. Islet purification was assessed by measuring tissue insulin and amylase concentrations, proportional to islet beta cell mass and exoc...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：BACKGROUND:Follicular thyroid cancer is a heterogeneous disease including follicular and Hürthle cell and tumors with and without vascular and major capsular invasion. Analyses of prognosis and risk groups have been criticized for not taking these differences into account. METHODS:Retrospective analysis was done of 24...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:The aims of this study were to determine whether ectopic pacemakers are present after meals in the Roux limbs of dogs after vagotomy and Roux gastrectomy, whether these pacemakers slow gastric emptying of liquids or solids, and whether abolishing the pacemakers with electric pacing might speed any slow emptying that o...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:We report a case in which a large, postoperative, biliary cutaneous fistula was successfully treated by means of endoscopic insertion of two endoprostheses into the common bile duct. Twenty-four hours after the procedure, bile flow from the cutaneous fistula ceased completely. The endoprostheses were removed after 6 w...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:Twelve patients with prior episodes of alcoholic pancreatitis and hyperlipemia were admitted to a metabolic ward during a quiescent period. By lipid feeding (316 to 894 Gm. per day), significant hypertriglyceridemia (greater than 600 mg. per 100 ml.) was induced in 11 of the 12 patients. Seven of the 11 patients with ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：INTRODUCTION:End-stage renal disease (ESRD) is associated with poor medical outcomes. This study aimed to compare early outcomes of elective and emergency operation for diverticulitis among older adults with and without a diagnosis of ESRD. METHODS:Patients 65 years of age and older with a primary diagnosis of diverti...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.03.034
更新日期：2014-08-01 00:00:00
abstract：:Lipopolysaccharide increases intestinal mucosal permeability to hydrophilic compounds such as chromium 51-labeled edetate (51Cr-EDTA). We sought to determine whether this phenomenon is partly mediated by lipopolysaccharide-induced mesenteric hypoperfusion. We assessed permeability in an isolated segment of ileum by me...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Sixty patients with recurrent ulcers after vagotomy were treated by partial gastrectomy without revagotomy. One patient died after surgery. Seven others died of unrelated causes and one patient was lost to follow-up before 5 years, without rerecurrence having been diagnosed. Of the remaining 51 patients, one underwent...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：BACKGROUND:We sought to determine the long-term effects of ABO-compatible donors (ACD) in adult cardiac transplantation (OHT). METHODS:The United Network for Organ Sharing database was examined for adult OHT from 2000 to 2010. RESULTS:Of 20,353 patients undergoing OHT, 3,046 (15%) were with ACD. Recipients of ACD wer...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.04.023
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Gross vascular invasion is a well-established prognostic indicator in hepatocellular carcinoma (HCC), but the biological significance of microscopic invasion remains unclear. METHODS:Curatively resected primary HCCs were classified retrospectively into 3 groups: HCCs without vascular invasion (V0), HCCs wit...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.09.037
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Biologic mesh choice in ventral hernia repair is challenging due to lack of prospective data. This study examines long-term, single-center biologic mesh outcomes. METHODS:Prospective operative outcomes data was queried for open ventral hernia repair with biologic mesh. Univariate and multivariate analysis w...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.07.008
更新日期：2016-12-01 00:00:00
abstract：:Radiation for benign problems of the head and neck area has been uniformly recognized as unacceptable practice. This includes epilation for facial hirsutism. Twelve such patients, recently encountered, have characteristic radiodermatitis facies and have demonstrated multisite neoplastic involvement--including skin, th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Salvage liver transplantation (SLT) has been proposed for recurrent hepatocellular carcinoma (HCC) after hepatectomy; however, it is unclear how the time interval to tumor recurrence from previous hepatectomy affects prognosis. METHODS:We analyzed retrospectively the outcomes of 62 patients who underwent SL...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.09.018
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Carcinoid tumors of the duodenum are rare, and their natural history has not been defined. Consequently, there is no consensus on the optimal extent of surgical treatment. METHODS:The authors reviewed the records of all patients with primary carcinoid tumors of the duodenum treated at their institution from...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.09.016
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Stress adaptation requires interactions between the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system, and a family of intracellular stress response proteins termed heat shock proteins (HSPs). These HSPs are present in every living organism and are selectively induced in the adrenal cortex ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:To assess the relative importance of cardiac versus peripheral vascular failure in patients dying of septic shock, a series of 42 patients with documented septic shock was retrospectively evaluated. Patients were included in the study if serial hemodynamic and metabolic studies had been performed: the first one within...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:A follow-up study was conducted to evaluate the late results of the operation that we have performed for ulcerative colitis and polyposis during the past 25 years. METHODS:Sixty-seven consecutive patients less than 21 years of age who underwent a standard operation for ulcerative colitis or polyposis perfor...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:Dynamic musculoplasty is increasingly being used to replace severely damaged muscle. Electrical stimulation induces a change in muscle composition from type II to type I muscle fibers. The aim of this study was to assess the optimal time to start stimulation and the beneficial effect of a vascular delay. ME...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90310-x
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND:Seeding of vascular grafts with genetically engineered human endothelial cells (hECs) secreting antithrombogenic or fibrinolytic agents has considerable clinical potential. METHODS:An adenoviral vector was used to transfer the human tissue-type plasminogen activator (htPA) gene to hECs, and the ability of t...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90269-5
更新日期：1997-07-01 00:00:00
abstract：:Ten cases of vascular compression of the duodenum are presented, and 125 cases in the literature since 1962 are reviewed. More common in women than in men, the lesion may result from supine immobilization, wearing body cast, or a rapid weight loss. In about one third of the patients, no predisposing factor can be foun...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：:A 20-year-old man underwent a 9-hour operation in a left lateral position for the removal of an osteoblastoma involving the pedicles of thoracic vertebrae T-11 and T-12 and for fixation with bond grafting. Immediately after the operation, extensive swelling of the left shoulder area was noted. The radial pulse on the ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:Gram-negative infections are a major cause of morbidity and death. Bactericidal permeability-increasing protein (BPI) is an endotoxin-neutralizing protein that also exhibits potent bactericidal activity. This study compared the efficacy of a 23 kd recombinant N-terminal fragment of BPI (rBPI23) with that of ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:Recent evidence suggests that gadolinium ethoxybenzyl diethylenetriamine penta acetic acid-enhanced (Gd-EOB-DTPA) magnetic resonance imaging may be used to evaluate liver function. The aim of this study was to assess whether the signal intensity of Gd-EOB-DTPA magnetic resonance imaging may be used to predic...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.04.041
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Successful parathyroidectomy for sporadic primary hyperparathyroidism (pHPT) is predicted by a 50% drop in PTH intra-operatively. Vitamin D is a known inhibitor of PTH secretion and is associated with secondary HPT following adenoma resection. This study examined the impact of 25-hydroxyvitamin D (25OHD) def...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.09.026
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Epithelialization of cutaneous ulcers is a long-lasting process. To study the pathomechanism of impaired epithelialization, we evaluated the role of cell cycle- and apoptosis-related proteins in the regenerating epidermis. We characterized immunohistochemically the expression of cell cycle regulators p63, CD...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2003.223
更新日期：2003-08-01 00:00:00
abstract：:In 112 patients with severe ischemia of the lower limb and without a suitable saphenous vein, 99 femoropopliteal and 22 femorodistal bypass procedures were performed with the modified human umbilical vein (Biograft, Meadox Medicals Inc., Oakland, N.J.). Seventy-eight percent of the operations were performed for limb s...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:This prospective study evaluates the use of intraoperative flexible choledochoscopy in the detection and removal of additional stones after conventional bile duct exploration. The biliary system of 109 patients was examined with an Olympus CHF-B4 choledochoscope after conventional methods of exploration. Sixty-five pa...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
abstract：BACKGROUND:Intraoperative parathyroid hormone (IOPTH) monitoring in parathyroidectomy for multigland disease is less clear than for single-gland disease. This study assesses the role of IOPTH for hyperplasia. METHODS:A prospective database revealed 45 patients with hyperplasia undergoing parathyroidectomy utilizing IO...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.05.060
更新日期：2004-12-01 00:00:00
abstract：:Myocardial high-energy phosphate and glucose-6-phosphate levels were determined in the in vivo pig heart model during ischemic arrest and reperfusion to determine the effectiveness of potassium cardioplegia in myocardial protection. Thirty-five pigs were divided into six experimental groups consisting of 2-hour normot...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
