Abstract：
:Several clinical studies have documented an increased incidence of gallstones after truncal vagotomy. Previous laboratory studies, however, have failed to establish a clear mechanism for this phenomenon. Whereas lithogenic bile is a prerequisite for cholesterol cholelithiasis, gallbladder stasis has also been shown to be a critical factor in stone formation. We tested the hypothesis that truncal vagotomy alters extrahepatic biliary function by performing either sham laparotomy or truncal vagotomy and pyloroplasty in the prairie dog. After operation, animals were fed a trace-cholesterol (nonlithogenic) diet for 3 months. In acute terminal experiments gallbladder bile was collected for determination of lithogenic index (LI). Resistance to flow through the sphincter of Oddi and cystic duct as well as gallbladder compliance were then determined. Sphincter of Oddi resistance was significantly elevated at 3 months after vagotomy (P less than 0.03). Cystic duct resistance, however, did not change significantly after vagotomy and pyloroplasty. Gallbladder compliance was significantly reduced in vagotomized animals (P less than 0.03). Gallbladder bile was unsaturated in both sham (LI = 0.47 +/- 0.09) and vagotomized animals (LI = 0.52 +/- 0.12), and gallstones did not develop in either group. Increased resistance to flow through the sphincter of Oddi after truncal vagotomy may represent the initial step leading to a gallbladder dilatation, bile stasis, and, ultimately, gallstone formation.
journal_name
Surgeryjournal_title
Surgeryauthors
Pitt HA,Doty JE,Roslyn JJ,DenBesten Lsubject
Has Abstractpub_date
1981-08-01 00:00:00pages
418-25issue
2eissn
0039-6060issn
1532-7361journal_volume
90pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:The aim of this study was to evaluate the incidence of complications in the upper limbs as a new event after radial artery (RA) harvesting for coronary artery bypass grafting (CABG). METHODS:From June 1997 to August 2001, the RA graft was used in 271 patients who underwent cardiac surgery at our department....
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2003.43
更新日期：2003-03-01 00:00:00
abstract：UNLABELLED:In patients undergoing pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PC), conversion to total pancreatectomy (TP) may be necessary to achieve R0 resection. HYPOTHESIS:We sought to examine the oncologic benefit of conversion of PD to TP to achieve an R0 resection in patients with an isolated po...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.07.016
更新日期：2007-10-01 00:00:00
abstract：:Nelson's syndrome--progressive cutaneous hyperpigmentation with x-ray film evidence of an expanding pituitary tumor--is now a well-recognized sequela of bilateral adrenalectomy for Cushing's disease. It is estimated to occur in 8% to 38% of adults. Because Cushing's disease is rare in children, a higher incidence of N...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:Discussion of the volume-outcome relationship in pancreatic surgery has gained increasing interest. Currently, no data describe the situation in Germany. Pursuant to a recent legislative reform, a threshold of 10 operations per year was introduced for pancreatic surgery in 2006. This study describes the situ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.05.011
更新日期：2012-09-01 00:00:00
abstract：:Human platelets suspended in autologous plasma do not respond to nonspecific immune complexes as do platelet suspensions from rabbits and dogs. However, platelets of all three species do undergo aggregation and the release reaction when exposed to antibodies directed against platelets. Antithymocyte globulin (ATG) con...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-04-01 00:00:00
abstract：:We studied the effect of the topical application of the nonsteroidal anti-inflammatory agent, flurbiprofen, on postburn hypermetabolism and systemic lipid peroxidation. Twelve sheep with a 15% total body surface third-degree burn were monitored over a 4-day postburn period. In six sheep, a single application of a 5% f...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:Certain behavioral traits and inadequate social support are known risk factors for complications after cancer surgery. Despite their importance, it is unclear whether conventional patient preoperative evaluation captures them. This study was conducted to assess concordance between documentation and patient s...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.04.015
更新日期：2019-08-01 00:00:00
abstract：:The utility of fine-needle aspiration biopsy to detect carcinoma in thyroid nodules was evaluated by a decision-analysis approach in 102 patients. The procedure caused no morbidity. Cytologic diagnoses were categorized as unsatisfactory (4), no abnormality detected (61), atypical (13), suspicious for malignancy (14), ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:This study examines the appropriateness of incidental appendectomy in the elderly. By examining the incidences of appendicitis and incidental appendectomy in 1977 in Wisconsin's elderly, this study calculated the chances that a citizen undergoing incidental appendectomy would have required otherwise an operation for a...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1980-08-01 00:00:00
abstract：:Diffuse compensatory extramedullary hematopoiesis is well known to involve the spleen and liver in certain hematologic disorders. Hematopoietic tumor masses occasionally form and usually occur paraspinally in the posterior mediastinum. A 31-year-old patient with thalassemia is described with a massive, solitary, intra...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:The mesoatrial shunt is performed in patients with the Budd-Chiari syndrome when the inferior vena cava is occluded and not available for a conventional portosystemic shunt. Computed tomography (CT), with injection of contrast media, was used to evaluate mesoatrial shunt patency with five examinations in four patients...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Although systems of 3-dimensional image-guided surgery are a valuable adjunct across numerous procedures, differences in organ shape between that reflected in the preoperative image data and the intraoperative state can compromise the fidelity of such guidance based on the image. In this work, we assessed in...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2017.04.020
更新日期：2017-09-01 00:00:00
abstract：:We investigated the active enhancement of liver allografts in 44 pairs of beagle dogs by pretreatment with semisoluble and soluble donor-specific spleen antigens. If the antigen were administered together with prednisolone, time of survival was significantly prolonged--with soluble antigen by 36.8 +/- 5.9 days and wit...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-11-01 00:00:00
abstract：:This is a report of a patient with a thrombosed Warren shunt and recurrent variceal hemorrhage who demonstrated compartmentalized venous hypertension in the mesenteric and gastrosplenic systems. Although the mesenteric presssure was normalized by the construction of a mesocaval interposition shunt, the gastrosplenic v...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:Vaccination of tumor-bearing animals with tumor cells genetically engineered to secrete cytokines including interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) has been shown to induce effective tumor-specific immune responses capable of inhibiting local and metastatic disease. Previous unsuccessful attemp...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80285-6
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to elucidate the mechanism of reduced intestinal transit rate in the ileum as compared with the jejunum. METHODS:Twenty-one dogs were each instrumented with 12 strain gauge transducers, 2 collection cannulas, and an infusion catheter defining a 100 cm study in the midjejunum (n...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90288-9
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Patients in the accelerated or blastic phases of chronic myelogenous leukemia (CML) often have painful splenomegaly and secondary thrombocytopenia. We tested the hypothesis that splenectomy can be performed with minimal complications in advanced CML, thereby alleviating pain, reversing thrombocytopenia, and ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90259-2
更新日期：1997-07-01 00:00:00
abstract：:The prevailing hypothesis of thyroid carcinogenesis is that thyroid-stimulating hormone (TSH) is a prime factor in the growth and possibly the genesis of thyroid carcinoma. On the other hand, Graves' disease is a hyperthyroid state caused presumably by human thyroid-stimulating immunoglobulin (HTSI), not TSH. However,...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:Ischemia and reperfusion lead to eicosanoid- and neutrophil (PMN)-dependent injury. This study tests the role of ischemia-induced lipoxygenase activity in mediating PMN activation and diapedesis. Anesthetized rabbits (n = 8) underwent 3 hours of bilateral hindlimb ischemia. At 10 minutes of reperfusion, leukotriene B4...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Between 1978 and 1985, 88 patients underwent insertion of the Greenfield vena cava filter. In 21 of the 88 patients (23.9%) the filter was inserted prophylactically. Sixteen of the 21 prophylactic insertions were performed before total joint replacement in patients with a history of venous thromboembolism. Operative m...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Burn-induced compartment syndrome is a severe sequela after circumferential burns of the extremities and is avoidable by immediate release of the underlying pressure under the eschar. Although the current gold standard is operative escharotomy, this procedure carries considerable morbidity. Our study evaluat...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.11.019
更新日期：2019-06-01 00:00:00
abstract：:The effectiveness of prosthetic femoropopliteal bypass grafts to salvage limbs and maintain long-term patency in lower extremities with a limited outflow tract is controversial. To evaluate the results of prosthetic grafts and compare them with the results of vein bypass grafts in limbs with a limited outflow tract, w...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-04-01 00:00:00
abstract：BACKGROUND:Associating liver partition and portal vein ligation for staged hepatectomy induces an unprecedented liver hypertrophy and enables resection of otherwise unresectable liver tumors. The effect of associating liver partition and portal vein ligation for staged hepatectomy on tumor proliferation, however, remai...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.10.036
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Routine central lymph node dissection (CLND) for papillary thyroid cancer (PTC) at the time of initial thyroidectomy has been advocated with a demonstrated decrease in post-ablation serum thyroglobulin compared to total thyroidectomy alone. Patients now present with central compartment metastatic disease aft...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.01.013
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Age-related loss of muscle mass and function (sarcopenia) is linked to poor outcomes after operation and trauma. Here we evaluate computed tomography measured psoas muscle density and area using quick and simple tools available to the bedside clinician. We hypothesize these measures will predict poor outcome...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.03.014
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Major operative injury initiates immunologic changes that may result in a systemic inflammatory response, leading to organ dysfunction/sepsis. Catecholamines seem to be key mediators. The effects of beta(2) receptor blockade in vitro and in vivo before and after operative injury were studied to clarify their...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.09.013
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:The aim of this prospective randomized controlled study was to investigate the effects of continuous venovenous hemofiltration on the hemodynamics and respiratory function of critically ill trauma patients with multiple organ dysfunction syndrome. METHODS:Thirty consecutive critically ill, mechanically vent...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0039-6060(97)90331-7
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:The long-term outcome of bilateral adrenalectomy in the management of patients with Cushing's syndrome has not been previously well studied. METHODS:We reviewed our long-term results in 34 patients treated with bilateral adrenalectomy between 1983 and the present. Fourteen presented with occult or metastati...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Successful parathyroidectomy for sporadic primary hyperparathyroidism (pHPT) is predicted by a 50% drop in PTH intra-operatively. Vitamin D is a known inhibitor of PTH secretion and is associated with secondary HPT following adenoma resection. This study examined the impact of 25-hydroxyvitamin D (25OHD) def...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.09.026
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:In living donor liver transplantation, variations in donor vascular anatomy, recipient portal vein thrombosis, short donor vessel length, and reconstitution of the anterior sector outflow in right lobe grafts often make complex and innovative vascular reconstructions necessary, which require the use of exten...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.10.008
更新日期：2008-07-01 00:00:00
