Abstract:
:We investigated the active enhancement of liver allografts in 44 pairs of beagle dogs by pretreatment with semisoluble and soluble donor-specific spleen antigens. If the antigen were administered together with prednisolone, time of survival was significantly prolonged--with soluble antigen by 36.8 +/- 5.9 days and with semisoluble antigen by more than 3 years. Antigen pretreatment alone or antigen in combination with postoperative treatment of minimal immunosuppressive drugs had no significant effects. We found no correlation between the titer of lymphocytotoxic antibodies in the serum of recipients at the time of transplantation and survival times.
journal_name
Surgeryjournal_title
Surgeryauthors
Lie TS,Nakano H,Bumanowski W,Rommelsheim Ksubject
Has Abstractpub_date
1976-11-01 00:00:00pages
565-8issue
5eissn
0039-6060issn
1532-7361journal_volume
80pub_type
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