Abstract:
:Recent reports demonstrate that culture of thyroid allografts before transplantation results in prolonged and sometimes indefinite survival. The loss of passenger leukocytes during organ culture was discussed as a possible reason for these findings. Recent data from a genetically defined system in the mouse demonstrated that passenger leukocytes play an important role in providing a helper stimulus which potentiates the generation of cytotoxic T cells to serologically defined determinants. To ascertain whether this mechanism also is involved in a xenogeneic system, cultured Wistar thyroids were transplanted to DBA/2 mice. The experimental system used was described first by Lafferty and co-workers. Thyroid function was determined by 125-iodine uptake of the graft and by histology. Fresh Wistar thyroids were rejected after a short period of good function on the sixth day after transplantation. Culturing for 10 days resulted in a prolonged graft function up to the fifteenth day. However, if the thyroids were kept in culture for 27 days, no functional signs of rejection could be detected on the twenty-fifth day after transplantation by iodine uptake. The iodine uptake ratio was 47.1 (control group on day 6 was 2.4). Injection of 10(5) fresh donor cells at the time of transplantation reversed the effect of long-term organ culture.
journal_name
Surgeryjournal_title
Surgeryauthors
Sollinger HW,Burkholder PM,Rasmus WR,Bach FHsubject
Has Abstractpub_date
1977-01-01 00:00:00pages
74-9issue
1eissn
0039-6060issn
1532-7361pii
0039-6060(77)90167-2journal_volume
81pub_type
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