Abstract：
:Peripheral parenteral nutrition avoids the use of central lines and is a useful means of nutritional support for selected patients. Amino acids alone have been used for peripheral parenteral nutrition and have been shown to give near nitrogen equilibrium. The addition of small amounts of dextrose to amino acids further improves nitrogen balance, but at the expense of making the solutions unsterilizable and unstable by standard techniques. Glycerol is a nonprotein calorie source that can be autoclaved with amino acids and stored. Fasting patients about to undergo major abdominal surgery were randomly allocated to receive 3% amino acids with or without 3% glycerol. The solution was infused by peripheral vein for 5 days, starting the morning following surgery. Routine monitoring, blood tests, and nitrogen balance tests were performed during this time. No adverse reactions to either solution were encountered. Liver function tests, electrolytes, and hematologic values were similar in both groups. The cumulative nitrogen balance was better in the amino acid plus glycerol group (+5 +/- 3.3 gm) than in the amino acid group (-9.7 +/- 3 gm) (P less than 0.02). Serum insulin levels were higher and serum free fatty acids lower in the amino acid plus glycerol group. Glycerol levels rose and plateaued by the third day in the amino acid plus glycerol patients. Amino acids plus glycerol is safe solution to administer by peripheral vein. The addition of glycerol improves nitrogen balance as compared to amino acids alone.
journal_name
Surgeryjournal_title
Surgeryauthors
Fairfull-Smith RJ,Stoski D,Freeman JBsubject
Has Abstractpub_date
1982-10-01 00:00:00pages
728-32issue
4eissn
0039-6060issn
1532-7361journal_volume
92pub_type
临床试验,杂志文章,随机对照试验相关文献
SURGERY文献大全abstract：BACKGROUND:Intraoperative parathyroid hormone (IOPTH) monitoring is well-established in operation for primary hyperparathyroidism (HPT). In diseases where total parathyroidectomy (tPx) is a treatment option its reliability to predict postoperative residual parathyroid hormone (PTH) remains in question. METHODS:Thirty-...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.02.003
更新日期：2007-07-01 00:00:00
abstract：:To clarify the physiopathologic mechanism leading to a marked increase in aromatic amino acids (AAA) in acute hepatic failure (AHF), we compared two experimental models of AHF. Ten pigs were submitted to one-stage hepatic devascularization (group A); in eight other pigs total hepatectomy was performed (group B). The a...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：BACKGROUND:In this study of laparoscopic splenectomy (LS), we evaluate prospectively gathered perioperative patient data and review lessons learned in the evolution of this procedure. METHODS:At 2 university medical centers between November 1993 and March 2000, there were 203 patients (122 female patients and 81 male ...
journal_title：Surgery
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1067/msy.2000.109065
更新日期：2000-10-01 00:00:00
abstract：CONTEXT:The rate and the extent of bone remineralization at cancellous versus cortical sites after treatment of hyperthyroidism is unclear. Few studies have examined the effect of operative management of hyperthyroidism on recovery of bone mass. OBJECTIVE:To evaluate prospectively the bone mineral density (BMD), bone ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.10.002
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Laparoscopy has become an increasingly important diagnostic tool for the staging of intraabdominal malignancies. Some investigators have suggested laparoscopy to be of questionable value in the preoperative staging of gastric cancer because many patients may require palliative surgery despite laparoscopic fi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80184-x
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:Portal vein reconstruction is a crucial factor affecting the outcome of a successful living-related liver transplantation. We describe here our experience with portal vein reconstruction in 314 cases of living-related liver transplantation with use of novel surgical modalities to enable the transplant surgeo...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:Management of <2-cm pancreatic neuroendocrine tumors is controversial. Although often indolent, the oncologic heterogeneity of these tumors particularly related to lymph node metastases poses challenges when deciding between resection versus surveillance. METHODS:We analyzed all patients who underwent resec...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.03.008
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Evidence indicates that sentinel node (SN) biopsy can accurately predict axillary nodal status. Debate exists as to the optimal method of SN identification. METHODS:Patients with clinical T1 or T2 tumors and negative axillae were randomized to SN localization with blue dye (B) alone (n = 50) or blue dye plu...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Liver resection (LR) for hilar cholangiocarcinoma (HCA) remains challenging because of the occurrence of unanticipated vascular and longitudinal bile duct invasion. Operative strategies to achieve negative resection margins vary, and the benefit of routine portal vein resection (PVR) is discussed controversi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.04.032
更新日期：2015-11-01 00:00:00
abstract：:In this study we describe the investigation and treatment of 14 patients with primary hepatocellular carcinoma. Patients were treated with intra-arterial infusion of iodized oil and doxorubicin hydrochloride. Five of these patients were alive after 1 year. Twelve patients showed a fall in alpha-fetoprotein, and in sev...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:The shear stress resistance of cultured human endothelium was investigated on 6 mm polytetrafluoroethylene vascular grafts. Endothelial cell attachment was promoted by precoating the grafts with fibrin glue, which contained human fibronectin and inhibitors of fibrinolysis (aprotinin and tranexam acid). To evaluate the...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:We wished to determine the role and significance of preoperative chemotherapy and radiotherapy in management of operable cancer of the esophagus. METHODS:Twenty-two patients with clinical stage I-II cancer of the esophagus were entered in a prospective study of preoperative chemotherapy (5-fluorouracil/cisp...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:The recent surge in enthusiasm for laparoscopic surgery has created concern that abdominal insufflation with carbon dioxide produces a respiratory acidosis. This may be because of both transperitoneal gas absorption and impaired ventilation with increased dead space from elevated intraabdominal pressure. To examine th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：INTRODUCTION:Hepatocyte cell transplantation can be life-saving in patients with acute liver failure (ALF); however, primary human hepatocyte transplantation is limited by the scarcity of donor hepatocytes. We investigated the effect of stem cell-derived, hepatocyte-like cells in an animal xenotransplant model of ALF. ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.04.014
更新日期：2015-08-01 00:00:00
abstract：:Thromboxane (Tx) inhibition prevents pulmonary leukostasis after acid aspiration. This observation prompted study of polymorphonuclear leukocyte (PMN) accumulations and products of cyclooxygenase. Experiments were conducted with a skin abrasion preparation. Five groups of six rabbits were pretreated intravenously with...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:The influence of diabetic therapies on myocardial substrate selection during cardiac surgery is unknown but may be important to ensure optimal surgical outcomes. We hypothesized that metformin and insulin alter myocardial substrate selection during cardiac surgery and may affect reperfusion cardiac function....
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.10.020
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Endotoxemia stimulates tumor necrosis factor (TNF) and interleukin-1 (IL-1) production in mucosa of the small intestine, but the effect on IL-6 production is not known. Intestinal IL-6 may be especially important, considering its role in the acute phase response. We tested the influence of endotoxemia and se...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80342-3
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:In the evaluation of patients with primary hyperparathyroidism (PHP), specific query for a personal or family history of MEN1 (Hx) is recommended widely, but responses are rarely positiv. We instituted a 6-question panel (6Q) to routinely screen for MEN1 preoperatively. METHODS:The clinical database entries...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.07.030
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:In clinically node-negative patients with differentiated thyroid cancer (DTC), indications for routine central lymph node dissection (RCLD) are the subject of intensive research, and surgeons are divided between the pros and cons of this surgery. To better define the role of neck dissection in the treatment ...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.surg.2014.02.010
更新日期：2014-06-01 00:00:00
abstract：:The hemodynamic significance of stenosis was defined by intraoperative measurement of pressure and flow across 22 profunda femoris and 44 iliac artery segments. Measurements were taken at rest and during papaverine-induced vasodilation, and the mean pressure gradient across the arterial segment at double resting flow ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:Four-dimensional computed tomography (4D-CT) provides both functional and highly detailed anatomic information about parathyroid tumors. The purpose of this study was to compare 4D-CT with sestamibi imaging and ultrasonography as methods for the accurate preoperative localization of hyperfunctioning parathyr...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2006.07.028
更新日期：2006-12-01 00:00:00
abstract：:We prospectively sampled 38 large soft tissue masses in 37 patients with both core needle biopsy (CNBX) and fine-needle aspiration (FNA) to determine the diagnostic utility of these biopsy methods. In 27 cases the histologic diagnosis made from the resected specimen was compared with the diagnosis based on the biopsy....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:The results of a 5-year experience with use of intraoperative radiation therapy (IORT) in the management of locally advanced bile duct carcinoma are presented. Fifteen patients received IORT doses between 5 and 20 Gy for localized disease, which was either primary and resected with microscopic residual (2 patients), p...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND:Although the effect of preoperative biliary drainage in patients with obstructive jaundice is controversial, bacterial or endotoxin translocation is one of the main postoperative problem in jaundiced patients. Failure in gut barrier functions causes bacterial translocation; homing and distribution of T lymph...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.02.001
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Routine and radical lymph node dissection is a clinical concern for improving the surgical outcome in patients with intrahepatic cholangiocarcinoma (ICC). The therapeutic value of the procedure during hepatectomy has, however, not been evaluated. METHODS:Between January 1990 and December 2004, 104 patients ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.11.010
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:Polypeptide growth factors have been shown to accelerate wound repair in rodent animal model systems. METHODS:In this report, insulin-like growth factor I (IGF-I) and the combination of IGF-I plus insulin-like growth factor binding protein (IGFBP-1) were applied directly to linear incisions made through dor...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Effective cytoprotection to xenoislets would circumvent the major tissue limitation for pancreatic islet transplantation (PIT). Cell-surface engineering with poly[ethylene glycol] (PEG) derivatives can successfully prevent antibody binding to the surface antigens. Gene transfer of the antiapoptotic Bcl-2 gen...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.05.031
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Identification of recurrent laryngeal nerve (RLN) has decreased the rates of permanent RLN palsy during thyroid operations; however, unexpected RLN palsy still occurs, even though the visual integrity was assured and most nerve injuries were not recognized intraoperatively. The aim of this study is to determ...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2008.02.006
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:In animal models of postoperative ileus (POI), inflammation of the intestine plays an important role in the pathogenesis of POI. Changes in alpha(2)-adrenoceptors and nitrergic regulation have been proposed to be implicated. The aim of our study was to investigate the presynaptic alpha(2)-receptor-mediated c...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.05.011
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:This study was undertaken to determine the true incidence of renal impairment after aortic surgery and its association with intraoperative fluctuations in renal artery blood flow and cardiac output. METHODS:Direct measurements of renal artery blood flow were undertaken with electromagnetic flowmetry in 19 p...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
