Abstract：
:The results of a 5-year experience with use of intraoperative radiation therapy (IORT) in the management of locally advanced bile duct carcinoma are presented. Fifteen patients received IORT doses between 5 and 20 Gy for localized disease, which was either primary and resected with microscopic residual (2 patients), primary and unresected (10 patients), or recurrent (3 patients). Thirteen patients also received postoperative radiation therapy. The median survival of the 12 patients with primary disease was 14 months, with disease controlled in the porta hepatis in 5 of 10 evaluable patients. The three patients with recurrent disease survived 2, 9, and 11 months. There were two operative deaths, for an operative mortality of 13%. Acute and chronic complications are reviewed. Cholangitis is the most frequent in both categories. This aggressive approach in the therapy for advanced disease has an acceptable level of morbidity and may warrant the use of IORT as part of the management of biliary tract cancer.
journal_name
Surgeryjournal_title
Surgeryauthors
Busse PM,Stone MD,Sheldon TA,Chaffey JT,Cady B,McDermott WV,Bothe A Jr,Jenkins R,Steele G Jrsubject
Has Abstractpub_date
1989-06-01 00:00:00pages
724-33issue
6eissn
0039-6060issn
1532-7361pii
0039-6060(89)90331-0journal_volume
105pub_type
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