Abstract：
BACKGROUND:Evidence indicates that sentinel node (SN) biopsy can accurately predict axillary nodal status. Debate exists as to the optimal method of SN identification. METHODS:Patients with clinical T1 or T2 tumors and negative axillae were randomized to SN localization with blue dye (B) alone (n = 50) or blue dye plus radioactivity (B+R) (n = 42). Patients undergoing needle localization (n = 47) were assigned to blue dye. RESULTS:The SN was identified in 110 patients (79%) and contained metastases in 28. The SN predicted the axillary nodal status in 96% of cases. The SN identification rate did not differ between B (88%) or B+R (86%) but was significantly lower in patients requiring localization (64%). The time to SN identification also did not differ between B and B+R. The number of cases done by an individual surgeon was a significant predictor of SN identification. A stepwise logistic regression analysis of factors influencing the success of SN identification identified tumor location, needle localization, number of operations, and body mass index as significant predictors. CONCLUSIONS:Our study does not identify any advantage for the use of the more expensive and complex method of SN identification using B+R compared with B alone, even for surgeons learning the techniques.
journal_name
Surgeryjournal_title
Surgeryauthors
Morrow M,Rademaker AW,Bethke KP,Talamonti MS,Dawes LG,Clauson J,Hansen Nsubject
Has Abstractpub_date
1999-10-01 00:00:00pages
714-20; discussion 720-2issue
4eissn
0039-6060issn
1532-7361pii
S0039-6060(99)70127-3journal_volume
126pub_type
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