Abstract：
BACKGROUND:We wished to determine the role and significance of preoperative chemotherapy and radiotherapy in management of operable cancer of the esophagus. METHODS:Twenty-two patients with clinical stage I-II cancer of the esophagus were entered in a prospective study of preoperative chemotherapy (5-fluorouracil/cisplatin) and radiotherapy (3405 cGy) administered concomitantly during 21 days followed by restaging and total esophagectomy. RESULTS:Five patients did not complete the protocol (three had toxicity, one refused surgery, and one had interim distant metastasis). Seventeen patients underwent total esophagectomy with cervical anastomosis. Two postoperative deaths resulted from sepsis. Thirteen (76%) of 17 patients were considered to have complete clinical response (esophagoscopy and computed axial tomographic scanning) before surgery, but only 5 (29%) of 17 were free of cancer. The median survival was 18 months (median follow-up 57 months). No difference in survival was seen between complete and partial pathologic response. CONCLUSIONS:(1) Preoperative chemotherapy and radiotherapy did not result in increased survival compared with historic controls (surgery alone). (2) Preoperative chemotherapy and radiotherapy clinical staging overestimates the incidence of complete tumor response. (3) Combination chemotherapy is well tolerated, but until newly developed drugs show their efficacy for treatment, surgery should continue to be the major modality for local control and an integral part of clinical investigational trials.
journal_name
Surgeryjournal_title
Surgeryauthors
Terz JJ,Leong LA,Lipsett JA,Wagman LDsubject
Has Abstractpub_date
1993-07-01 00:00:00pages
71-5issue
1eissn
0039-6060issn
1532-7361journal_volume
114pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:The long-term outcome of bilateral adrenalectomy in the management of patients with Cushing's syndrome has not been previously well studied. METHODS:We reviewed our long-term results in 34 patients treated with bilateral adrenalectomy between 1983 and the present. Fourteen presented with occult or metastati...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Retroperitoneal sarcomas are rare tumors that can be locally aggressive with high rates of recurrence. Given that data on survival in patients with retroperitoneal sarcomas are conflicting, we sought to use a nationwide cancer database to identify factors associated with survival in patients with retroperito...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.05.041
更新日期：2016-12-01 00:00:00
abstract：:The relationship between the cyclosporine A (CSA) dose and rejection of varying lengths of small-bowel grafts was studied in a rat heterotopic microsurgical small-bowel transplantation model involving a haploidentical strain combination. When Lewis X Brown Norway F1 hybrid (LBN) small-bowel grafts were transplanted in...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND:With increasing pressure to optimize the utilization of hospital resources, it is important to identify patients who may have prolonged hospital length of stay (LOS). The purpose of this report was to identify the preoperative variables that are predictive of prolonged postoperative hospital LOS for patients...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80194-2
更新日期：1996-06-01 00:00:00
abstract：:Adenocarcinomas of the colon arise from adenomatous polyps. We hypothesized that sucrase-isomaltase (SI), a glycoprotein hydrolase, found in normal small intestine, fetal colon, and colon carcinomas is a marker associated with progression of adenomatous polyps with dysplasia to adenocarcinomas. To examine this hypothe...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Resident evaluation is highly subjective and continues to be a problem. Personality traits and characteristics account for 28% of factors considered; deficits in this area account for 22% of advanced residency terminations. Sixty-four faculty members and 51 residents in six university surgical departments were surveye...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：:A dominant belief throughout the last half of the 1970s was that operative rates in the United States continued to show steady increases. This strongly suggested that an excessive number of operations were being performed. Unsubstantiated statements regarding surgical rates have been accepted at face value, and little...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-02-01 00:00:00
abstract：BACKGROUND:The role of routine prophylactic central-neck lymph node dissection (CLND) for papillary thyroid cancer (PTC) remains controversial. We perform CLND for PTC only in patients with enlarged nodes as determined by preoperative ultrasound and intraoperative inspection and palpation. METHODS:We identified all pa...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.03.021
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Adequate surgical care is lacking in many low- and middle-income countries because of diverse barriers preventing patients from reaching providers. We sought to assess perceived difficulties to accessing surgical care in Nepal using the Surgeons OverSeas Assessment of Surgical Need tool. METHODS:Fifteen of ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.03.012
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Classic surgical treatment of upper third gastric carcinoma is based on an extended total gastrectomy, including splenectomy. The purpose of this study was to perform a prospective randomized clinical trial comparing the early and late results of total gastrectomy (TG) versus total gastrectomy plus splenecto...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1067/msy.2002.121891
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:This study was undertaken to test the hypothesis that perfluorocarbons were able to reduce myocardial infarct size in a baboon model of ischemia-reperfusion injury. Exchange transfusion of perfluorocarbons has been shown to reduce myocardial infarct size in the dog, who, unlike the baboon, has an extensive c...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(95)80011-5
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:To determine the characteristics associated with improved accuracy or reliability of estimating operative blood loss. METHODS:Operating room personnel at a tertiary care hospital evaluated 3 operative simulations and provided estimations of blood loss. The simulations utilized precise, known volumes of porc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.06.006
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Laparoscopic adrenalectomy (LA) is a safe minimally invasive approach for treatment of pheochromocytoma (PHEO). Posterior retroperitoneoscopic adrenalectomy (PRA) is an alternative minimally invasive technique; however, there is a lack of data regarding the appropriateness of this approach in patients with...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.07.004
更新日期：2011-09-01 00:00:00
abstract：:The splanchnic and total body oxygen exchange and flow dynamics for injured patients (n = 7) and patients with sepsis and stable vital signs (n = 12) were studied. All patients were judged to be in the hyperdynamic phase of the stress response. In both patient groups 27% to 28% of the cardiac index was directed to the...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Ten patients who had a cricopharyngeal myotomy and diverticulum suspension for pharyngoesophageal diverticulum have been studied clinically, radiologically, and manometrically. There were no deaths or morbidity and all patients have achieved marked improvement of their symptoms. Before operation all patients but one h...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：BACKGROUND:Despite successful revascularization of ischemic extremities, multiorgan dysfunction syndrome develops in some patients. Mechanisms responsible for this are not known; however, the gastrointestinal tract has been implicated as a possible mediator. Our objective was to demonstrate increased intestinal mucosal...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80076-6
更新日期：1996-09-01 00:00:00
abstract：:We studied 28 patients who had undergone 30 operations for pheochromocytoma since 1964. The tumor types included bilateral, extra-adrenal, malignant, recurrent, and multiple endocrine neoplasia, with 20 tumors confined to the adrenal gland. The preoperative studies used to localize the tumor included ultrasonography, ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:This investigation documented the effect of protamine sulfate pretreatment on the adverse hemodynamic and hematologic sequela of rapid intravenous protamine administration in heparinized dogs having undergone prior implantation of aortic prostheses. Fourteen dogs underwent infrarenal aortic replacement with 6 mm inner...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：BACKGROUND:Medullary carcinoma of the thyroid gland (MCT) is a disease commonly associated with regional metastases. Apart from surgical resection, there are limited therapeutic options for such patients. Given the variable and often prolonged survival of such patients, the benefit of surgical resection is difficult to...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Extrinsic denervation of the transplanted small bowel could play a substantial role in motor dysfunction of the transplanted gut. We attempted to determine the effect of chronic extrinsic denervation on intestinal contractility. METHODS:Jejunal longitudinal muscle strips were obtained from rats 1 week and 8...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.112070
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:With the large amounts of data on patient, tumor, and treatment factors available to clinicians, it has become critically important to harness this information to guide clinicians in discussing a patient's prognosis. However, no widely accepted survival calculator is available that uses national data and inc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.08.006
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Up to 70% of children with small bowel transplantation (SBTx) experience acute cellular rejection (ACR). Allospecific CD154+ T cells predict liver ACR in children in a novel, 16-hour mixed leukocyte response (MLR) assay, but remain untested in SBTx. METHODS:The expression of CD154 was measured in 4 subsets-...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.04.006
更新日期：2009-08-01 00:00:00
abstract：:An occlusion of the superior vena cava by a tumor thrombus extending into the right atrium was diagnosed in three patients with a follicular thyroid cancer. All patients showed the typical clinical picture of the superior vena cava syndrome. A right parasternal thoracotomy was performed for preparation of the major ve...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND:The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle al...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.01.017
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Small intestinal submucosa (SIS) represents a novel bio-scaffolding material that may be used to repair hollow-organ defects. However, it is unclear whether neurophysiologic responses return to SIS-grafted areas in the gut. We evaluated the functional recovery of a stomach defect grafted with the porcine-der...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.04.019
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Although various suture techniques for murine pancreas transplantation have been described, severe limitations have limited their widespread use. We therefore designed a surgical model for cervical heterotopic pancreas transplantation using a cuff technique. METHODS:C57BL6 mice were used as donor and recipi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.07.037
更新日期：2007-05-01 00:00:00
abstract：:One hundred thirty-three patients with familial adenomatous polyposis undergoing colectomy and ileorectal anastomosis have been reviewed for the occurrence of cancer in the rectal stump. Ten patients developed rectal cancer (Actuarial survivorship rate of 88% for those patients free of rectal cancer at 20 years). Pote...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:The benefit of utilizing surgical safety checklists has been recently questioned. We evaluated our checklist performance after implementing a program that includes checklist-related good catches. METHODS:Multifaceted interventions aimed at the preincision checklist and 5 prospective audits were conducted fr...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.04.038
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:An altered immune microenvironment may contribute to papillary thyroid cancer development, as immune infiltrates are identified postoperatively in many papillary thyroid cancer cases with or without diagnosed thyroiditis. Oxygen radicals, endogenous or inflammation-induced, can generate DNA damage, which cau...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.02.024
更新日期：2020-01-01 00:00:00
abstract：:A patient with an uncommon cause of portal venous hypertension, pancreatitis, is depicted. The patient had an equally uncommon pattern of symptoms and signs consisting of abdominal pain and lower gastrointestinal hemorrhage caused by colonic varices. A unique treatment, with angiographic placement of an expandable int...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
