Abstract:
BACKGROUND:An altered immune microenvironment may contribute to papillary thyroid cancer development, as immune infiltrates are identified postoperatively in many papillary thyroid cancer cases with or without diagnosed thyroiditis. Oxygen radicals, endogenous or inflammation-induced, can generate DNA damage, which causes mutations when repaired incorrectly. We hypothesized that infiltrating immune cells might promote aberrant DNA repair, predisposing thyrocytes to papillary thyroid cancer. METHODS:Quantitative reverse-transcriptase polymerase chain reaction assays measured gene expression in fresh-frozen samples (n = 55). RNA-seq data was obtained for papillary thyroid cancer and normal thyroid samples from the Cancer Genome Atlas (n = 564), and Hashimoto's-affected and normal thyroids from the Genotype-Tissue Expression project (n = 279). Immune cell marker expression levels were compared to histological estimates and to selected DNA repair genes. Immunohistochemistry localized gene expression to specific cell types. RESULTS:DNA polymerase theta expression by quantitative reverse-transcriptase Polymerase chain reaction was higher in papillary thyroid cancer and papillary thyroid cancer-adjacent samples than in benign normal thyroid (P < .001). Immune markers including CD4 correlated with DNA polymerase theta expression (r = 0.50) but not other DNA repair genes examined. Benign tissue with Hashimoto's exhibited increased DNA polymerase theta (P < .0001) and CD3E (P < .0001) expression. DNA polymerase theta localized to thyrocytes, not lymphocytes. CONCLUSION:We identified a strong correlation between immune cell infiltrate and dysregulated thyrocyte DNA repair genes, likely reflecting a pathway to papillary thyroid cancer development.
journal_name
Surgeryjournal_title
Surgeryauthors
Nicolson NG,Brown TC,Korah R,Carling Tdoi
10.1016/j.surg.2019.02.024subject
Has Abstractpub_date
2020-01-01 00:00:00pages
66-72issue
1eissn
0039-6060issn
1532-7361pii
S0039-6060(19)30459-3journal_volume
167pub_type
杂志文章相关文献
SURGERY文献大全abstract::Ten patients who had a cricopharyngeal myotomy and diverticulum suspension for pharyngoesophageal diverticulum have been studied clinically, radiologically, and manometrically. There were no deaths or morbidity and all patients have achieved marked improvement of their symptoms. Before operation all patients but one h...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to review and discuss our observations on 33 patients who underwent surgical treatment for Caroli's disease (CD), focusing on diagnosis, current surgical management, and long-term outcome. METHODS:Between May 1993 and June 2004, 642 liver resections and 286 liver transplantations i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.05.002
更新日期:2005-11-01 00:00:00
abstract::The records of patients with carcinoma of the extrahepatic bile ducts, including the ampulla of Vater, operated on at the University of Rochester Medical Center between 1960 and 1980 were reviewed. All 47 patients had similar manifestations and laboratory findings; percutaneous transhepatic cholangiography and endosco...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Although pentoxifylline has been shown to improve tissue oxygenation and restore hepatocellular function after hemorrhagic shock, its effect on hepatic ischemia and reperfusion injury has not been fully clarified. The purpose of this study was to determine whether pentoxifylline exerted beneficial effects on...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90106-9
更新日期:1997-05-01 00:00:00
abstract::Dr McCarthy is a fellow in cardiothoracic surgery at the University of Washington. During his general surgery training at Northwestern University, he completed a research fellowship in surgical innovation and obtained masters' degrees with a focus on health enterprise management, entrepreneurship, and innovation. ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.08.035
更新日期:2017-04-01 00:00:00
abstract::Arteriosclerotic aneurysm of the innominate artery is an unusual lesion. A review of the literature has revealed many approaches to this problem in the past, but the mortality rate has remained significant and serious complications have been frequent. Computerized axial tomography and noninvasive cerebrovascular metho...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:Data from a US multicenter longitudinal study of bariatric surgery were used to compare weight change (primary outcome) and comorbidities (secondary outcome) in patients who underwent sleeve gastrectomy versus Roux-en-Y gastric bypass. METHODS:This study includes participants who underwent sleeve gastrectom...
journal_title:Surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.surg.2018.06.008
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Postoperative cervical hemorrhage is a rare but life-threatening complication that can cause severe morbidity. Different mechanisms leading to asphyxia have been described based only on clinical observation. METHODS:We performed a series of in vivo animal studies simulating post-thyroidectomy hemorrhage and...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.05.022
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Gastroparesis is characterized by delayed gastric emptying in the absence of obstruction. Common symptoms include nausea, vomiting, and abdominal pain. Severe gastroparesis can result in recurrent hospitalizations, malnutrition, and even death. Gastric electrical stimulation (GES) is a low morbidity treatmen...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.06.024
更新日期:2008-10-01 00:00:00
abstract::Nelson's syndrome--progressive cutaneous hyperpigmentation with x-ray film evidence of an expanding pituitary tumor--is now a well-recognized sequela of bilateral adrenalectomy for Cushing's disease. It is estimated to occur in 8% to 38% of adults. Because Cushing's disease is rare in children, a higher incidence of N...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Apoptosis, a mechanism of cell death prominent in critical illnesses including disseminated inflammation and multiorgan dysfunction syndrome, is characterized by morphologic changes including cell shrinkage, condensation of organelles, blebbing, and chromatin fragmentation. These phenomena suggest substantia...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::A 5 MHz continuous-wave Doppler probe was used intraoperatively to evaluate 25 in situ saphenous vein bypass grafts. At least one arteriovenous fistula per case and five retained competent posterior valvular leaflets were identified before completion angiography. The Doppler was able to distinguish a retained valve fr...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Adhesions to polypropylene mesh used for abdominal wall hernia repair may eventuate in intestinal obstruction or enterocutaneous fistula. A Seprafilm Bioresorbable Membrane translucent adhesion barrier has been shown to inhibit adhesions. This investigation was designed to determine if Seprafilm alters abdom...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.106810
更新日期:2000-07-01 00:00:00
abstract:CONTEXT:The rate and the extent of bone remineralization at cancellous versus cortical sites after treatment of hyperthyroidism is unclear. Few studies have examined the effect of operative management of hyperthyroidism on recovery of bone mass. OBJECTIVE:To evaluate prospectively the bone mineral density (BMD), bone ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.10.002
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Gender differences have been noted in acute ischemia/reperfusion injury. Estrogen and the estrogen receptors (ER) appear to play a critical role in cardiovascular gender differences, given that females have improved myocardial functional recovery associated with decreased tissue inflammation. It has been sug...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.03.009
更新日期:2008-08-01 00:00:00
abstract::Cadaver allograft skin, porcine xenograft skin, and amniotic membranes have been proved to be adequate temporary thermal wound coverings in four clinical situations: coverage of shallow wounds while awaiting epithelialization (SW), coverage of deep wounds after eschar excision (DEW), coverage of widely meshed autograf...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::Multifocal colonic carcinoma occurred in a 65-year-old man with a 13 year history of colonic Crohn's disease. The relationship between solitary and multiple colonic cancer and Crohn's disease is discussed. ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract::To reevaluate the validity of our policy of mandatory surgical exploration of penetrating zone II neck injuries, the charts of 110 patients who underwent surgical exploration for such injuries were reviewed. Fifty-three percent of the patients had normal findings at exploration, whereas 33% had injuries involving vasc...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:The effects of intestinal inflammation on the central nervous system are unknown. The dorsal motor nucleus of the vagus (DMNV) integrates peripheral and central signals and sends efferent signals to the gastrointestinal system. The purpose of this study was to determine the effects of intestinal inflammation...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.03.042
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Major postoperative complications are associated with a substantial increase in hospital costs. Trauma patients are known to have a higher rate of complications than the general surgery population. We used the National Surgical Quality Improvement Program (NSQIP) methodology to evaluate hospital costs, durat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.05.003
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Patients with primary mediastinal lymphomas frequently present with a residual mass after completion of first-line therapy. Although a positron emission tomography scan is usually recommended, it fails to distinguish between persistent lymphoma and inflammation. Although percutaneous biopsy may have a high d...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.05.039
更新日期:2018-10-01 00:00:00
abstract::In an experimental canine model of isolated and tandem arterial stenoses, noninvasive thigh and calf pressure measurements were evaluated against direct intra-arterial pressures. Under control circumstances, proximal iliac arterial stenosis, and high superficial femoral artery stenosis, the noninvasive measurements we...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::A retrospective study was performed on 65 patients with intractable angina and subtotal coronary occlusions undergoing aortocoronary artery bypass (ACB) to determine whether the local occlusion (L.O.) or the ischemic arrest (I.A.) technique was perferable in performing the distal coronary artery bypass. In 23 patients...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:Burn-induced compartment syndrome is a severe sequela after circumferential burns of the extremities and is avoidable by immediate release of the underlying pressure under the eschar. Although the current gold standard is operative escharotomy, this procedure carries considerable morbidity. Our study evaluat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.11.019
更新日期:2019-06-01 00:00:00
abstract::The deep inferior epigastric artery and vein may be satisfactorily utilized for chronic hemodialysis in patients who have no extremity vessels available. ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-11-01 00:00:00
abstract:BACKGROUND:The gastrointestinal mucosa is an important route of entry for microbial pathogens. The immune cells of Peyer's patch (PP) compartments contribute to the active immune response against infection. Although local anesthetics are widely used in clinical practice, it remains unclear whether local anesthetics suc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.03.024
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Cholecystosteatosis is the accumulation of gallbladder wall fats leading to decreased gallbladder emptying. Ezetimibe inhibits intestinal fat absorption and prevents murine gallstone formation. However, the influence of ezetimibe on gallbladder emptying and cholecystosteatosis has not been studied. Therefore...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.04.007
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Depression has been associated with delayed presentation, inadequate treatment, and poor survival in patients with cancer. METHODS:Using Surveillance, Epidemiology and End Results and Medicare linked data (1992-2005), we identified patients with pancreatic adenocarcinoma (N = 23,745). International classifi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.06.010
更新日期:2012-09-01 00:00:00
abstract::In a prospective study the accuracy of B-mode ultrasound imaging alone was compared with its use in conjunction with bidirectional Doppler ultrasound, carotid phonoangiography, and oculoplethysmography to independently assess contrast arteriograms of carotid arteries studied for presumed extracranial vascular disease....
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:This study examines factors associated with the performance of orthotopic liver transplantation (OLT) without red blood cell (RBC) transfusion. METHODS:Between January 1992 and December 1994, 306 primary OLTs were performed with recipients divided into two groups: group 1 patients (61 recipients, 20% of tot...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80019-5
更新日期:1996-10-01 00:00:00