Abstract：
BACKGROUND:The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle alteration of neuroblastoma cells and determined its effects on neuroblastoma tumors in mice. METHODS:Cytotoxic effects, cellular apoptosis, and alterations in the cell cycle were determined in neuro-2a neuroblastoma cells exposed for varying lengths of time to a series of resveratrol concentrations. Expression of associated cell cycle regulatory proteins, cyclin E and p21, was detected by Western blot analysis, and the antitumor effects of resveratrol were investigated by treating subcutaneous neuroblastoma tumors with intraperitoneal injections of 40 mg/kg resveratrol daily for 28 days. RESULTS:Resveratrol exerted cytotoxic effects on neuroblastoma cells. After resveratrol treatment, the apoptosis rate of the neuroblastoma cells significantly increased, a significant accumulation of cells occurred at the S phase of the cell cycle, p21 was downregulated, and cyclin E was upregulated. In addition, resveratrol treatment suppressed the growth rate of subcutaneous neuroblastomas, resulting in 70% long-term survival. CONCLUSION:Resveratrol caused significant cytotoxicity and increased apoptosis and S-phase accumulation of neuroblastoma cells. S-phase accumulation was related to the down-regulation of p21 and up-regulation of cyclin E. In addition, resveratrol exerted antitumor effects on neuroblastomas in mice. Thus, resveratrol shows promise for the treatment of neuroblastoma.
journal_name
Surgeryjournal_title
Surgeryauthors
Chen Y,Tseng SH,Lai HS,Chen WJdoi
10.1016/j.surg.2004.01.017subject
Has Abstractpub_date
2004-07-01 00:00:00pages
57-66issue
1eissn
0039-6060issn
1532-7361pii
S0039606004000923journal_volume
136pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:Bilateral axillo-breast approach (BABA) robotic thyroidectomy (RoT) has good postoperative and excellent cosmetic outcomes. To assess the surgical completeness of BABA RoT, it was compared to open thyroidectomy (OT) after propensity score matching of the cohorts. METHODS:Between 2008 and 2010, 760 patients ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.09.015
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to prospectively compare the effect of laparoscopic cholecystectomy (LC) versus open cholecystectomy (OC) on postoperative pulmonary function. METHODS:Forty consecutive patients (20 in each group) who were evenly matched in terms of pulmonary risk factors were assigned to eithe...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1097/00132586-199406000-00036
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:Patients with colon cancer often present with obstruction. Large series have reported obstruction among the high-risk features, yet prospective data on its specific prognostic influence are lacking. We hypothesized that obstruction is an independent risk factor for poor prognosis in patients with stage III c...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2018.06.044
更新日期：2018-12-01 00:00:00
abstract：:One hundred sixty patients had preoperative mediastinoscopy, resection of the primary tumor, and complete mediastinal lymphadenectomy for non-small-cell carcinoma of the lung. Minimum follow-up was 24 months (mean 40 months). Postoperative staging based on histologic examination of the specimen of the lung and mediast...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：BACKGROUND:The connective tissue component hyaluronan is accumulated locally in the damaged tissue during various inflammatory conditions. Owing to the strong water-binding capacity of this glycosaminoglycan, increased tissue content of hyaluronan is paralleled by the development of interstitial edema. The aim with the...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.106587
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Living-donor liver transplantation has become a legitimate alternative to cadaveric liver transplantation. However, information on the perioperative management of donors is still scarce. METHODS:Between October 1996 and May 2001, 52 consecutive living-donor liver transplantations have been performed at the ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.119576
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Barriers to trauma care for rural populations are well documented, but little is known about the magnitude of urban-rural disparities in injury mortality. This study sought to quantify differences in injury mortality comparing rural and nonrural residents with traumatic injuries. METHODS:Using data from the...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.06.020
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Visceral artery aneurysms are an uncommon but important form of abdominal vascular disease. This study reviews a contemporary experience with special emphasis on newer methods of diagnosis and treatment. METHODS:From 1980 to 1994, 37 patients were diagnosed with 46 visceral artery aneurysms. These consisted...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80009-2
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:The role of histocompatibility between donor and recipient in liver transplant rejection is unclear because of a paucity of data. The influence of human leukocyte antigen (HLA) type on immunologic graft loss was examined for primary liver transplantations performed at this center. METHODS:Immunologic graft ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Major intra-abdominal operations result in profound immunodepression. In addition, manipulation of malignant tumors may release tumor cells into the systemic and portal circulations. The additive effects of immunodepression and tumor cell release may enhance the metastatic potential of tumors. Perioperative correction...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:Resection of T4 colon cancer remains challenging compared to lower T stages. Data on the effect of neoadjuvant radiation to improve resectability and survival are lacking. The purpose of this study is to describe the use and outcomes of neoadjuvant radiation therapy in clinical T4 colon cancer. METHODS:Adul...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.06.015
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine which peripheral intravenous nutrition (IVN) regimen, one containing 70% nonprotein calories as lipid IVN or one containing all nonprotein calories as glucose IVN, was most effective at reversing some effects of surgery on protein metabolism. METHODS:Twenty patient...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-01-01 00:00:00
abstract：:The purpose of this study was to develop a method that would provide baseline data for the ongoing assessment of surgical clerkships at The University of Michigan Medical School. Of specific concern was the comparability of clerkship experiences among five different sites and the degree of variability in student exper...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：BACKGROUND:Postoperative hepatic decompensation is a serious complication of liver resection in patients undergoing hepatectomy for hepatocellular carcinoma. Liver fibrosis and clinical significant portal hypertension are well-known risk factors for hepatic decompensation. Liver stiffness measurement is a noninvasive m...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.06.006
更新日期：2017-10-01 00:00:00
abstract：INTRODUCTION:Hypothermia is a well-known risk factor for postoperative complications because it prolongs the monocyte inflammatory response. The purpose of this study was to investigate whether temperature-activated ion channels (transient receptor protein channels [TRP] A1 and V1) mediate the effects of temperature on...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.03.065
更新日期：2015-09-01 00:00:00
abstract：:Two patient groups were studied to determine the need to preserve the greater saphenous vein during femoral outflow reconstruction for later aortocoronary bypass procedures. First, 74 patients were followed to the time of death or to a minimum of 5 years after femoral outflow reconstruction was performed. Only four pa...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：BACKGROUND:Anaplastic thyroid cancer is an aggressive and fatal malignancy. Many advanced cancers are characterized by glucose dependency, leading to oxidative stress and cellular proliferation. Therefore, we sought to determine if a low glucose environment (in vitro) or a ketogenic diet (in vivo) could inhibit anaplas...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.06.042
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the genotype-phenotype relationship of pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 treated at our institution. METHODS:We conducted a retrospective chart review of all patients with multiple endocrine neoplasia type 1 treated...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.04.044
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Recent evidence suggests that gadolinium ethoxybenzyl diethylenetriamine penta acetic acid-enhanced (Gd-EOB-DTPA) magnetic resonance imaging may be used to evaluate liver function. The aim of this study was to assess whether the signal intensity of Gd-EOB-DTPA magnetic resonance imaging may be used to predic...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.04.041
更新日期：2020-09-01 00:00:00
abstract：:The standard stainless steel Greenfield filter was modified by extending the limbs at the apex to permit loading into a 12F carrier for percutaneous insertion. This model was tested for fixation and resolution of experimental embolism in dogs (six filters in four dogs) and sheep (eight suprarenal filters in eight shee...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine whether intraoperative parathyroid hormone (IOPTH) assay improved results of reoperations. METHODS:One hundred two patients with persistent/recurrent sporadic primary hyperparathyroidism underwent 108 reoperations (1996-2002). IOPTH was not used (n=58) from 1996-19...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2003.08.007
更新日期：2003-12-01 00:00:00
abstract：:Radiation for benign problems of the head and neck area has been uniformly recognized as unacceptable practice. This includes epilation for facial hirsutism. Twelve such patients, recently encountered, have characteristic radiodermatitis facies and have demonstrated multisite neoplastic involvement--including skin, th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Small intestinal submucosa (SIS) represents a novel bio-scaffolding material that may be used to repair hollow-organ defects. However, it is unclear whether neurophysiologic responses return to SIS-grafted areas in the gut. We evaluated the functional recovery of a stomach defect grafted with the porcine-der...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.04.019
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Thyroid nodules are common; fine-needle aspirations commonly are read as indeterminate, necessitating surgery to exclude carcinoma. We developed a 6-gene array-based predictor model to diagnose benign versus malignant thyroid lesions. In this study, we verified whether quantitative reverse transcription-poly...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.09.010
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:The existence of primary gastrinomas in lymph nodes continues to be controversial, because distinction from metastases from occult or regressed primary tumors may be difficult to exclude with certainty. If primary nodal gastrinomas do indeed occur, precursor neuroendocrine cells should be identifiable within...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80100-x
更新日期：1995-12-01 00:00:00
abstract：:Prevention of ischemic bowel complications following abdominal aortic reconstruction requires identification of the patient at high risk for developing the complication; on precise, gentle, meticulous operative technique; on knowledge of bowel blood supply; on determining when the IMA must be reconstructed or when it ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:Lung injury in severe acute pancreatitis is mediated by infiltrating leukocytes. Our laboratory has previously demonstrated that acute lung injury in acute pancreatitis results in an up-regulation of vascular adhesion molecule-1 (VCAM-1) cell surface receptor expression on pulmonary vascular endothelium and ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2003.84
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Central line-associated bloodstream infections occur commonly and are a potentially preventable source of morbidity in the critical care setting. The purpose of this study was to find a way to decrease central line-associated bloodstream infections. METHODS:Data were collected from February 1, 2005, to Apri...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.06.004
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Breast milk has been shown to prevent gut-origin infections in neonates through undefined mechanisms. Putative protective factors in breast milk include immunoglobulin (Ig)A, IgG, and lactoferrin. We examined their role in bacterial translocation in neonatal rabbits. METHODS:IgA, IgG, and lactoferrin were i...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Major postoperative complications are associated with a substantial increase in hospital costs. Trauma patients are known to have a higher rate of complications than the general surgery population. We used the National Surgical Quality Improvement Program (NSQIP) methodology to evaluate hospital costs, durat...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.05.003
更新日期：2008-08-01 00:00:00
