Abstract：
:Major intra-abdominal operations result in profound immunodepression. In addition, manipulation of malignant tumors may release tumor cells into the systemic and portal circulations. The additive effects of immunodepression and tumor cell release may enhance the metastatic potential of tumors. Perioperative correction of immune depression by levamisole can restore lymphocyte proliferation levels in rats. We have developed a model in which rat colon carcinoma cells transplanted into the portal venous system consistently induce hepatic metastases by 4 weeks and death within 9 weeks. Rats pretreated with levamisole (4 mg/kg administered intraperitoneally) the day before and the day of tumor implantation developed fewer metastases (41% of animals treated with levamisole compared with 6% of animals not treated with levamisole had less than or equal to two metastases per liver). Twenty percent of the rats treated with levamisole developed no hepatic metastases. Comparison of median liver weights between the group treated with levamisole and the nontreated, tumor-bearing group was highly significant (p less than 0.005). We conclude that the perioperative period is critical for the implantation and growth of metastases and that perioperative immunostimulation may be a factor in decreasing the incidence of metastases. This model may have relevance to the adjuvant treatment of human colon cancer.
journal_name
Surgeryjournal_title
Surgeryauthors
Weese JL,Gilbertson EM,Syrjala SE,Starling JRsubject
Has Abstractpub_date
1984-08-01 00:00:00pages
420-6issue
2eissn
0039-6060issn
1532-7361journal_volume
96pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:The aims of the present study were to confirm the consumption coagulopathy of disseminated intravascular coagulation with the fibrinolytic phenotype at an early phase of trauma and to test the hypothesis that thrombin-activatable fibrinolysis inhibitor, neutrophil elastase, and plasmin contribute to the incr...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.06.010
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide. Greater than 90% of SCCHN of the oropharynx overexpress the epidermal growth factor receptor (EGFR or HER1). Cetuximab (Erbitux-TM) is a humanized anti-HER1 monoclonal antibody (mAb) that binds to HER1 overexpress...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.05.035
更新日期：2012-09-01 00:00:00
abstract：:During the past 3 years (June, 1974, to July, 1977), 51 patients underwent reoperation for persistent or recurrent hyperparathyroidism at the Mayo Clinica. The overall success rate for cervical reoperation was 72% and for mediastinal reoperation, was 64%. Arteriography alone provided accurate preoperative localization...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：BACKGROUND:Patient-reported outcomes (PRO) reflect the functional outcomes of inguinal herniorrhaphy. We studied the effect of hernia recurrence and complications on PRO for participants in the Veterans Affairs trial of Open or Laparoscopic Repair of Inguinal Hernia. METHODS:Analyzed PRO included (1) the Medical Outco...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2006.02.003
更新日期：2006-08-01 00:00:00
abstract：INTRODUCTION:Rapid thrombelastography (rTEG) has been advocated as a point-of-care test to manage trauma-induced coagulopathy. rTEG activated clotting time (T-ACT) results become available much sooner than other rTEG values, thus offering an attractive tool to guide blood component transfusion in a hemorrhagic shock. W...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.04.017
更新日期：2014-09-01 00:00:00
abstract：:This study was designed to show whether weight-losing cancer patients have an elevated glycerol turnover. Four groups of patients were examined: weight-losing cancer patients, weight-losing patients without cancer, cancer patients without weight loss, and weight-stable and well-nourished hospitalized control patients....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:A model for the vascular steal phenomenon was designed and evaluated in 10 mongrel dogs in which the aortic bifurcation was used to represent a parent artery with two distal vascular beds. Right lower extremity flow was increased with a femoral arteriovenous fistula, and progressively greater stenoses were applied to ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:Resident evaluation is highly subjective and continues to be a problem. Personality traits and characteristics account for 28% of factors considered; deficits in this area account for 22% of advanced residency terminations. Sixty-four faculty members and 51 residents in six university surgical departments were surveye...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：:That the fetus swallows amniotic fluid and has the capability of intestinal absorption of protein and carbohydrate is known, but its significance in fetal nutrition is not clear. We have infused nutrient solutions of dextrose and amino acids intra-amniotically in a chronic third-trimester fetal rabbit model and examin...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:The utility of fine-needle aspiration biopsy to detect carcinoma in thyroid nodules was evaluated by a decision-analysis approach in 102 patients. The procedure caused no morbidity. Cytologic diagnoses were categorized as unsatisfactory (4), no abnormality detected (61), atypical (13), suspicious for malignancy (14), ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:Physical and psychosocial morbidity of multiple endocrine neoplasia type-1 is ill-defined. How disease and treatment-related factors relate to patient-reported outcomes including health-related quality of life is unknown. We hypothesized that disease and treatment burden negatively impacts health-related qua...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.07.023
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Expendable autologous nerve available for repair of nerve injuries is limited. Cadaveric allografts could provide adequate nerve for grafting but are susceptible to rejection and currently require chronic systemic immunosuppression. METHODS:Age-matched Buffalo (RT1B) rats randomly assigned to 7 experimental...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:With increasing pressure to optimize the utilization of hospital resources, it is important to identify patients who may have prolonged hospital length of stay (LOS). The purpose of this report was to identify the preoperative variables that are predictive of prolonged postoperative hospital LOS for patients...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80194-2
更新日期：1996-06-01 00:00:00
abstract：:Twelve patients with prior episodes of alcoholic pancreatitis and hyperlipemia were admitted to a metabolic ward during a quiescent period. By lipid feeding (316 to 894 Gm. per day), significant hypertriglyceridemia (greater than 600 mg. per 100 ml.) was induced in 11 of the 12 patients. Seven of the 11 patients with ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：BACKGROUND:Vascular endothelial growth factor-D (VEGF-D), the activating ligand for vascular endothelial growth factor receptor-3 (VEGFR-3), has been identified as an important endogenic tumor-associated lymphangiogenic factors which can promote lymphatic metastasis from primary tumor. Lymphatic metastasis, which is th...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.04.025
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:The purpose of this study was to evaluate whether ultrasonography is helpful in predicting malignancy in patients with a thyroid nodule and atypia/follicular lesion of undetermined significance (AFLUS). METHODS:All patients with a preoperative ultrasound who underwent thyroidectomy for a nodule with AFLUS comp...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.06.043
更新日期：2014-10-01 00:00:00
abstract：:The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared wi...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:An understanding of the regeneration power and operative risk of steatotic livers after hepatectomy is still unclear. We evaluated the volume regeneration and outcome of steatotic livers after donor hepatectomy. METHODS:Fifty-four, consecutive living liver donors from September 2002 to December 2003 were ev...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.09.007
更新日期：2006-04-01 00:00:00
abstract：:Pancreatic polypeptide (PP) deficiency has been associated with impaired hepatic sensitivity to insulin and pancreatogenic diabetes in chronic pancreatitis. Since pancreatic resection might also result in PP deficiency, hepatic responses to insulin infusion (0.25 mU/kg/min) were determined by the euglycemic glucose cl...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:Lung contusion (LC) is a unique direct and focal insult that is considered a major risk factor for the initiation of acute lung injury and acute respiratory distress syndrome. We have shown recently that consumption of nitric oxide (due to excess superoxide) resulting in peroxynitrite formation leads to decr...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.05.023
更新日期：2013-11-01 00:00:00
abstract：:Ischemia and reperfusion lead to eicosanoid- and neutrophil (PMN)-dependent injury. This study tests the role of ischemia-induced lipoxygenase activity in mediating PMN activation and diapedesis. Anesthetized rabbits (n = 8) underwent 3 hours of bilateral hindlimb ischemia. At 10 minutes of reperfusion, leukotriene B4...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：OBJECTIVES:Outpatient thyroid surgery is becoming increasingly common. The aim of this study was to clarify the principles for safe outpatient thyroid surgery and review our outcomes with the use of a protocol for outpatient thyroidectomy in a large patient cohort. STUDY DESIGN:A systematic analysis of a prospectively...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.08.007
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Totally implantable venous access devices (ports) are widely used, especially for cancer chemotherapy. Although their use has been associated with upper extremity deep venous thrombosis, the risk factors of upper extremity deep venous thrombosis in patients with a port are not studied adequately. METHODS:Th...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.02.020
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Interaction of the CD11/CD18 complex on polymorphonuclear neutrophils (PMNs) and intercellular adhesion molecule (ICAM)-1 on endothelium is a critical event in PMN-mediated tissue injury. In addition, increased expression of ICAM-1 on type I pneumocytes has been identified in a variety of pulmonary disorders...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80320-4
更新日期：1995-08-01 00:00:00
abstract：:A case of transient cerebral and retinal ischemia caused by giant cell arteritis is reported. Because of the distribution of the disease, the patient was treated with a subclavian to carotid reversed saphenous vein graft. The clinical features of giant cell arteritis affecting the branches of the aortic arch are revie...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：BACKGROUND:In humans with chronic pancreatitis (CP), pancreatic interstitial pressure (IP) is elevated and pancreatic blood flow (PBF) is reduced. The efficacy of surgical decompression (SD) of the pancreatic duct (ie, pancreaticojejunostomy) is believed to be due to its ability to decrease IP and pancreatic vascular r...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:The outcomes of operative repair of intestinal-cutaneous fistulas vary widely throughout the literature. We aimed to investigate whether the modified frailty index-5 is a reliable tool to account for physiologic reserve and whether it serves as a predictor of Clavien-Dindo grade IV complications in those wit...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.11.018
更新日期：2021-01-04 00:00:00
abstract：BACKGROUND:The observed to expected (O:E) mortality based on Injury Severity Scores (ISS) has been used to assess quality of trauma center (TC) care. Injuries in the elderly have increased, and these patients often have advanced directives, on occasion limiting aggressive care even for potentially survivable injuries; ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.07.065
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:An altered immune microenvironment may contribute to papillary thyroid cancer development, as immune infiltrates are identified postoperatively in many papillary thyroid cancer cases with or without diagnosed thyroiditis. Oxygen radicals, endogenous or inflammation-induced, can generate DNA damage, which cau...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.02.024
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Obesity is known as a risk factor for intra- and postoperative complications in pancreatic operation. However, the operative outcomes in obese patients undergoing laparoscopic distal pancreatectomy remain unclear. METHODS:A total number of 423 patients underwent laparoscopic distal pancreatectomy at Oslo Un...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.05.046
更新日期：2016-11-01 00:00:00
