Abstract：
BACKGROUND:This study was undertaken to test the hypothesis that perfluorocarbons were able to reduce myocardial infarct size in a baboon model of ischemia-reperfusion injury. Exchange transfusion of perfluorocarbons has been shown to reduce myocardial infarct size in the dog, who, unlike the baboon, has an extensive collateral circulation. METHODS:After 15 minutes of occlusion of the left anterior descending coronary artery, 14 baboons were bled to attain a hematocrit of 24% to 26% and were simultaneously transfused, six with Fluosol-DA 20% emulsion and eight with FC-43 emulsion. After 2 hours of ligation, the coronary arteries were reperfused. Baboons were killed 24 hours after ligation, and the hearts were excised. Microvascular dye was infused into the coronary artery to delineate its perfusion bed. Ratios of the mean volume of infarct to the mean volume of perfusion bed were calculated and compared by use of planimetry. A similar protocol was followed in two other groups of baboons except that lactated Ringer's solution was infused into six of them, whereas eight had no exchange transfusions. RESULTS:The ratios of the mean volume of infarct to the mean volume of perfusion bed of the four groups were as follows: Fluosol-DA, 38.1% +/- 7.5%; FC-43, 37.7% +/- 8.3%; lactated Ringer's, 46.9% +/- 10.5%; controls, 65.6% +/- 6.9%. Statistical significance was reached when comparing both perfluorocarbon-treated groups with the controls (p < 0.05 for both groups) but not significant when comparing them with the Ringer's lactate-treated group. CONCLUSIONS:Results suggest that the beneficial effects of exchange transfusion with the perfluorocarbons may be primarily due to hemodilution.
journal_name
Surgeryjournal_title
Surgeryauthors
Premaratne S,Harada RN,Chun P,Suehiro A,McNamara JJdoi
10.1016/s0039-6060(95)80011-5subject
Has Abstractpub_date
1995-06-01 00:00:00pages
670-6issue
6eissn
0039-6060issn
1532-7361pii
S0039-6060(95)80011-5journal_volume
117pub_type
杂志文章相关文献
SURGERY文献大全abstract：:We prospectively sampled 38 large soft tissue masses in 37 patients with both core needle biopsy (CNBX) and fine-needle aspiration (FNA) to determine the diagnostic utility of these biopsy methods. In 27 cases the histologic diagnosis made from the resected specimen was compared with the diagnosis based on the biopsy....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:A case of a nonanastomotic, atheromatous aneurysm in a femoropopliteal saphenous vein graft is presented. This disease is unusual, especially in nonsmokers with normal lipid levels, and, in this case, may be related to mechanical graft failure 22 years after implantation. The aneurysm was excised and the arterial cont...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:We carried out a prospective, randomized, 4-arm study including control arm, blinding of examiners to determine effectiveness of computer-based video instruction (CBVI) and different types of expert feedback (concurrent and summary) on learning of a basic technical skill. METHODS:Using bench models, partici...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2006.09.012
更新日期：2007-04-01 00:00:00
abstract：:Tony is a practicing frontline National Health Service surgeon and director of medical innovation at Anglia Ruskin University and has founded 4 medical-technology start-ups. He has also cofounded the £500 million Anglia Ruskin MedTech Campus, which will become one of the world's largest health innovation spaces. In 20...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.07.039
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Patient-reported outcomes (PRO) reflect the functional outcomes of inguinal herniorrhaphy. We studied the effect of hernia recurrence and complications on PRO for participants in the Veterans Affairs trial of Open or Laparoscopic Repair of Inguinal Hernia. METHODS:Analyzed PRO included (1) the Medical Outco...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2006.02.003
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:The landscape of patients with end-stage renal disease is changing with the increasing availability of kidney transplantation. In the near future, a less aggressive approach to treat secondary hyperparathyroidism might be beneficial. We report outcomes of parathyroidectomy for end-stage renal disease-related...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.08.014
更新日期：2021-02-01 00:00:00
abstract：:The effectiveness of prosthetic femoropopliteal bypass grafts to salvage limbs and maintain long-term patency in lower extremities with a limited outflow tract is controversial. To evaluate the results of prosthetic grafts and compare them with the results of vein bypass grafts in limbs with a limited outflow tract, w...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-04-01 00:00:00
abstract：:An unusual case of Mondor's disease associated with carcinoma of the breast is reported. "Forked string" and "triple beads" have been reported previously in this disease. In this patient, however, one of the "beads" of her triple beads was malignant. It is suggested that biopsy and histologic examination are the best ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:Ischemia and reperfusion lead to eicosanoid- and neutrophil (PMN)-dependent injury. This study tests the role of ischemia-induced lipoxygenase activity in mediating PMN activation and diapedesis. Anesthetized rabbits (n = 8) underwent 3 hours of bilateral hindlimb ischemia. At 10 minutes of reperfusion, leukotriene B4...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Hypoxia is a common tumor condition correlated with therapeutic resistance. Ribonucleotide reductase (RR) is a rate-limiting enzyme for viral replication. We hypothesize that hypoxia-driven transcription of UL39, the gene encoding the large subunit of RR, would enhance herpes oncolytic viral therapy in breas...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.04.016
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Previous studies have reported on the association between perioperative morbidity and diminished oncologic outcomes in patients undergoing resection for colorectal or pancreatic cancer. However, the effect of anastomotic leak (AL) on the survival of patients with gastric or esophageal cancer remains unclear....
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.02.020
更新日期：2016-07-01 00:00:00
abstract：:The effect of chronic electrical stimulation on muscle mass of pedicled diaphragmatic muscle grafts (DMGs) implanted into the right ventricle was studied in 21 dogs. Nineteen dogs, followed up to 70 days (mean, 34 days), were divided into three groups. In six dogs (control) the DMG was not stimulated. In six other dog...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：BACKGROUND:Depression has been associated with delayed presentation, inadequate treatment, and poor survival in patients with cancer. METHODS:Using Surveillance, Epidemiology and End Results and Medicare linked data (1992-2005), we identified patients with pancreatic adenocarcinoma (N = 23,745). International classifi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.06.010
更新日期：2012-09-01 00:00:00
abstract：:A girl underwent partial resection of the liver for mesenchymal hamartoma twice, at 7 months and again at 3 years of age. When the patient was 16 years of age, the mass increased rapidly in size. The patient was hospitalized and studied by ultrasonography, computed tomographic scans, and arterial angiography. The tumo...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：BACKGROUND:Both weight loss and gastrointestinal surgery for obesity can cause liver disease, making their role in the treatment of obesity-related liver disease controversial. METHODS:Six hundred eighty-nine severely obese women (n=551) and men (n=138), BMI=47+/-9 kg.m(-2) (mean+/-SD), without known liver disease, un...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2003.10.003
更新日期：2004-01-01 00:00:00
abstract：:Aneurysms of the gastroduodenal artery are rare. Only nine cases have been reported previously. These aneurysms are extremely difficult to diagnose preoperatively. A case of ruptured gastroduodenal artery aneurysm, which was diagnosed by aortography prior to operation, is reported, and the literature is reviewed. ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
abstract：BACKGROUND:Gastroparesis is characterized by delayed gastric emptying in the absence of obstruction. Common symptoms include nausea, vomiting, and abdominal pain. Severe gastroparesis can result in recurrent hospitalizations, malnutrition, and even death. Gastric electrical stimulation (GES) is a low morbidity treatmen...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.06.024
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Activated factor X (FXa) is involved in hemostasis, thrombogenesis, inflammation, and cellular immune response. Tissue factor (TF) is an initiator of blood coagulation. We investigated whether FXa induces TF expression in human peripheral monocytes and whether treatment with FXa inhibitor reduces TF expressi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.116452
更新日期：2001-11-01 00:00:00
abstract：:Sixty patients with recurrent ulcers after vagotomy were treated by partial gastrectomy without revagotomy. One patient died after surgery. Seven others died of unrelated causes and one patient was lost to follow-up before 5 years, without rerecurrence having been diagnosed. Of the remaining 51 patients, one underwent...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：:Palliative care has long been described in medical literature but only recently is being discussed in the surgical domain. Mounting evidence suggests that early integration of palliative care improves patient outcomes and this is especially true of oncology patients. Thus, the pendulum is swinging toward recognizing t...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.10.001
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Laparoscopic ultrasound (LUS) is a method of intraoperative bile duct imaging that can be used prior to any potentially hazardous dissection. The purpose of this study was to determine whether LUS could permit safe laparoscopic completion of difficult cholecystectomy (LC) cases and to assess whether its use ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.04.041
更新日期：2013-10-01 00:00:00
abstract：:A model for the vascular steal phenomenon was designed and evaluated in 10 mongrel dogs in which the aortic bifurcation was used to represent a parent artery with two distal vascular beds. Right lower extremity flow was increased with a femoral arteriovenous fistula, and progressively greater stenoses were applied to ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:During the past 3 years (June, 1974, to July, 1977), 51 patients underwent reoperation for persistent or recurrent hyperparathyroidism at the Mayo Clinica. The overall success rate for cervical reoperation was 72% and for mediastinal reoperation, was 64%. Arteriography alone provided accurate preoperative localization...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：BACKGROUND:Four-dimensional computed tomography (4D-CT) provides both functional and highly detailed anatomic information about parathyroid tumors. The purpose of this study was to compare 4D-CT with sestamibi imaging and ultrasonography as methods for the accurate preoperative localization of hyperfunctioning parathyr...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2006.07.028
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Patients with colon cancer often present with obstruction. Large series have reported obstruction among the high-risk features, yet prospective data on its specific prognostic influence are lacking. We hypothesized that obstruction is an independent risk factor for poor prognosis in patients with stage III c...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2018.06.044
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:We hypothesized that most contralateral breast cancers (CBCs) develop ≥5 years after the primary breast cancer (PBC) and that CBCs have more favorable tumor characteristics. METHODS:This is a single-institution retrospective review of 323 patients who were diagnosed with CBC from 1990 to 2014. CBCs were d...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.03.059
更新日期：2015-09-01 00:00:00
abstract：:To study the role of antibodies in promoting survival during gram-negative bacterial sepsis, we have developed several murine monoclonal antibodies (MAbs). One MAb (5B10) reacted in an enzyme-linked immunosorbent assay with only a single organism (Escherichia coli 0111:B4), while the other (8A1) reacted to all gram-ne...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：:Peripheral lymphocytes, T cells, and T cell subsets of 141 consecutive patients with colorectal cancer were measured preoperatively to determine whether infectious complications could be predicted from derangements of T cell subsets. T cell subset abnormalities reportedly precede sepsis in patients with burn injuries....
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：BACKGROUND:Laparoscopic Nissen fundoplication (LNF) is gaining popularity. Although the hemodynamic effects of the typical pneumoperitoneum have been studied, the additional consequences of the hiatal dissection necessary for LNF have not. METHODS:Seven female pigs were anesthetized, intubated, and ventilated with a v...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90026-x
更新日期：1997-08-01 00:00:00
abstract：BACKGROUND:Serologic and anthropometric measures are commonly used as surrogate markers of nutritional status in clinical practice. In 2012, leading dietetic organizations published a standard definition of malnutrition based on clinical characteristics. We hypothesize that surrogate markers underrecognize clinical mal...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.08.012
更新日期：2020-12-01 00:00:00
