Abstract：
BACKGROUND:Up to 70% of children with small bowel transplantation (SBTx) experience acute cellular rejection (ACR). Allospecific CD154+ T cells predict liver ACR in children in a novel, 16-hour mixed leukocyte response (MLR) assay, but remain untested in SBTx. METHODS:The expression of CD154 was measured in 4 subsets-naive (N) and memory (M) CD154+ T-helper (Th) and T-cytotoxic (Tc) cells (ie, CD154+ ThN, CD154+ ThM, CD154+ TcN, and CD154+ TcM, respectively)-in the MLR of single blood samples obtained from 32 children with SBTx within 60 days of SBTx biopsy. Children showing ACR in these biopsies were termed Rejectors. The ratio of donor-induced to third-party-induced CD154+ T cells was called the immunoreactivity index (IR). We hypothesized that IR >1 denoted increased donor-specific alloreactivity and increased risk of rejection; in contrast, IR <1 implied decreased risk. CD154 expression was correlated with the expression of CTLA4, a negative T-cell costimulator that antagonizes and is inversely related to CD154 (n = 18). RESULTS:Rejectors showed significantly greater numbers of donor-specific CD154+ T-cell subsets. Logistic regression analysis and leave-one-out cross validation followed by receiver operating characteristic analysis showed that, among the 4 subsets, IR > or =1.23 for CD154+ TcM identified Rejectors with a sensitivity and specificity of 93% and 88%. Also, a significant negative correlation was observed between CD154 expression and CTLA4 expression in allospecific Tc (Spearman's rho = -0.616, P = .006) but not in Th. CONCLUSION:Allospecific CD154+ TcM identify rejection-prone children with SBTx.
journal_name
Surgeryjournal_title
Surgeryauthors
Ashokkumar C,Gupta A,Sun Q,Ningappa MB,Higgs BW,Mazariegos G,Fazzolare T,Remaley L,Soltys K,Bond G,Abu-Elmagd K,Sindhi Rdoi
10.1016/j.surg.2009.04.006subject
Has Abstractpub_date
2009-08-01 00:00:00pages
166-73issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(09)00232-3journal_volume
146pub_type
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