Abstract:
BACKGROUND:Neuroendocrine neoplasms most commonly metastasize to the liver. Operative extirpation of neuroendocrine neoplasm hepatic metastases improves symptoms and seems to improve survival, but subsequent evidence is required. The current study evaluates the progression-free survival and overall survival of patients after resection (with or without ablation) of neuroendocrine neoplasm hepatic metastases. As a secondary endpoint, the prognostic factors associated with progression-free survival and overall survival were evaluated. METHODS:Seventy-four patients with neuroendocrine neoplasm hepatic metastases underwent hepatic resection between December 1992 and December 2009. Thirty-eight patients underwent synchronous cryoablation. Patients were assessed radiologically and serologically at monthly intervals for the first 3 months and then at 6-month intervals after treatment. Progression-free survival and overall survival were determined; clinicopathologic and treatment-related factors associated with progression-free survival and overall survival were evaluated through univariate and multivariate analyses. RESULTS:No patient was lost to follow-up. The median follow-up for the patients who were alive was 41 months (range, 1-162). The median progression-free survival and overall survival after hepatic resection were 23 and 95 months, respectively. Five- and 10-year overall survival were 63% and 40%, respectively. Two independent factors were associated with overall survival: histologic grade (P < .001) and extrahepatic disease (P = .021). The only independent predictor for progression-free survival was pathologic margin status (P = .023). CONCLUSION:In selected patients, aggressive operative extirpation of neuroendocrine neoplasm hepatic metastases is effective in achieving long-term survival. Disease progression, however, is a common occurrence; therefore, a multimodality treatment approach for progressive disease is necessary. Integrating the knowledge of identified prognostic factors can both improve patient selection and identify patients at greatest risk of treatment failure.
journal_name
Surgeryjournal_title
Surgeryauthors
Saxena A,Chua TC,Sarkar A,Chu F,Liauw W,Zhao J,Morris DLdoi
10.1016/j.surg.2010.06.008subject
Has Abstractpub_date
2011-02-01 00:00:00pages
209-20issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(10)00332-6journal_volume
149pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:The reconstruction of outflow is a crucial step in living donor liver transplantation. This study describes a suitable technique that uses synthetic vascular conduits in presence of multiple draining veins of right lobe of liver and the outcome of the recipients to evaluate safety of using multiple synthetic...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.03.018
更新日期:2015-11-01 00:00:00
abstract::Since there appears to be an association between depressed lymphocyte function and liver disease, the effect of bile salts on lymphocyte function was determined in vitro. Peripheral lymphocytes from normal volunteers were incubated with varying concentrations of three bile salts (chenodeoxycholate, deoxycholate, or ur...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract::Eighty-four patients with recurrent kidney stones, serum calcium levels in the upper normal quartile, and most of whom with hypercalciuria had their parathyroids surgically explored. Parathyroid adenomata were found in 19 patients, hyperplasia in 39, and normal parathyroids in 26. Postoperatively there was a significa...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Central line-associated bloodstream infections occur commonly and are a potentially preventable source of morbidity in the critical care setting. The purpose of this study was to find a way to decrease central line-associated bloodstream infections. METHODS:Data were collected from February 1, 2005, to Apri...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.06.004
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Meckel's diverticulum (MD) is one of the most common congenital gastrointestinal malformations. It is difficult to make a preoperative diagnosis of MD. To date, few data are available describing the diagnosis of MD by double-balloon enteroscopy (DBE) and capsule endoscopy (CE). METHODS:To assess the value o...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.09.012
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:T cells that receive T-cell antigen receptor signals but do not undergo mitosis become unresponsive to subsequent antigenic stimulation. This can be achieved by antigen presentation to T cells in the absence of critical costimulatory signals from antigen-presenting cells (APC) or in the presence of the antip...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::Eleven parathyroid cysts were found in 325 patients who underwent parathyroid operations. Ten cysts were located in the neck and one was located in the mediastinum. The cysts ranged in size from 1.6 to 10 cm with a mean of 3.9 cm. The patients who had cysts included six women and five men, and their ages ranged from 2...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Recurrence of adrenal cortical carcinoma (ACC) after radical surgery is a common finding. Although successful reoperations have been reported with encouraging results, most published experiences are anecdotal and based on few cases. We report the results of surgical treatment for recurrent ACC in a multiinst...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90229-4
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:The aim of this prospective randomized controlled study was to investigate the effects of continuous venovenous hemofiltration on the hemodynamics and respiratory function of critically ill trauma patients with multiple organ dysfunction syndrome. METHODS:Thirty consecutive critically ill, mechanically vent...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0039-6060(97)90331-7
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:In anticipation of developing gene therapy against thyroid carcinoma we created an expression vector using the thyroglobulin (Tg) gene promoter. The inhibition of both Tg and thyroid-specific transcription factor (TTF-1 and PAX-8) gene expression, however, has been well documented in thyroid carcinomas. We t...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.1998.92008
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Cancer anorexia is influenced by the neuropeptidergic and monoaminergic systems. We hypothesize that serotonin (5-HT), dopamine (DA) and neuropeptide Y (NPY) concentrations in paraventricular (PVN), ventromedial (VMN), and lateral hypothalamus (LHA) areas are abnormal in tumor-bearing rats. METHODS:Fifty-fi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.03.016
更新日期:2004-08-01 00:00:00
abstract::Necrotizing enterocolitis, a highly lethal disease in the newborn infant characterized by ischemic necrosis of the gastrointestinal tract frequently leading to perforation, is seen primarily in low birth weight infants who have undergone stress, such as hypoxia. In an animal model it was demonstrated that cold stress ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::The purpose of this project was to evaluate the acute and chronic effects of sclerotherapy on esophageal motility and function. We studied motility in eight patients before and after injection sclerotherapy of esophageal varices. We injected the varices with 5% sodium morrhuate twice during the first week and then at ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Patients with locally advanced pancreatic cancer have historically been considered inoperable. The purpose of this report was to determine resectability rates for patients with locally advanced pancreatic cancer based on our recently described definitions of type A and type B locally advanced pancreatic canc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.09.012
更新日期:2018-05-01 00:00:00
abstract::Until recently, vascular surgeons have had to make judgments based on an impression of their experiences rather than upon the actual facts. Presently, with the simplified and less costly use of computers, the establishment of a computerized data base is feasible. Our goal had been to develop a system suitable for micr...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::From 1960 to 1988, 266 patients underwent resection of colorectal secondaries to the liver with curative intent. All patients were followed until April 1, 1990, or death, with a median follow-up time of 52 months. Nine patients with minimal macroscopic residual disease and 38 patients with all gross tumor removed but ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:The purpose of this study is to detail the use of advanced tissue transfer techniques to achieve primary closure of the perineal wound after proctectomy for Crohn's disease. METHODS:Between October 1984 and March 2000, we performed proctectomy with permanent intestinal stoma in 97 patients with Crohn's dise...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2001.117100
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:The impact of the location of colorectal cancer on patient outcomes has been reported in several settings. The objective of this study was to assess the prognostic impact of the location of the primary colon cancer among patients with colorectal cancer peritoneal metastases undergoing complete cytoreductive ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.07.027
更新日期:2019-02-01 00:00:00
abstract::We measured lipid peroxidation of plasma, lung, and liver in anaesthetized sheep after third-degree burns involving 30% of total body surface. Animals were resuscitated to baseline filling pressures with lactated Ringer's solution and killed 10 hours after burn. Six sheep were pretreated with ibuprofen (12.5 mg/kg) an...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Pancreatic polypeptide (PP) deficiency has been associated with impaired hepatic sensitivity to insulin and pancreatogenic diabetes in chronic pancreatitis. Since pancreatic resection might also result in PP deficiency, hepatic responses to insulin infusion (0.25 mU/kg/min) were determined by the euglycemic glucose cl...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Traumatic injury is strongly associated with long-term mental health disorders, but the risk factors for developing these disorders are poorly understood. We report on a multi-institutional collaboration to collect long-term patient-centered outcomes after trauma, including screening for post-traumatic stres...
journal_title:Surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.surg.2018.07.017
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Clinical parameters influencing the effect of preoperative portal vein embolization (PVE) in hypertrophying the nonembolized lobe of patients with either normal or abnormal liver parenchyma and its effect upon portal pressure were examined to identify the patient population for whom this approach is most sui...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2002.118259
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Acupuncture is a safe and well-tolerated treatment for pain relief. Previous studies supported the effectiveness of several acupuncture techniques for postoperative pain. The aim of this randomized, controlled trial was to evaluate the efficacy of acupuncture in reducing pain after thyroid surgery. METHODS:...
journal_title:Surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.surg.2014.08.062
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The physiologic assessment of anal sphincters in cases of posttraumatic fecal incontinence is a fundamental step in planning operative treatment. In this study, we evaluate the correlation between size of anal sphincter defect, anal pressures, and clinical symptoms in patients with posttraumatic fecal incont...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.05.020
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Routine and radical lymph node dissection is a clinical concern for improving the surgical outcome in patients with intrahepatic cholangiocarcinoma (ICC). The therapeutic value of the procedure during hepatectomy has, however, not been evaluated. METHODS:Between January 1990 and December 2004, 104 patients ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2008.11.010
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:It was shown in a murine model that sham laparotomy is associated with a higher incidence of postoperative lung metastases when compared with results seen after carbon dioxide pneumoperitoneum. Using the same tumor model, the present study was undertaken to determine if the addition of bowel resection to the...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/s0039-6060(03)00136-3
更新日期:2003-09-01 00:00:00
abstract::During the past 3 years (June, 1974, to July, 1977), 51 patients underwent reoperation for persistent or recurrent hyperparathyroidism at the Mayo Clinica. The overall success rate for cervical reoperation was 72% and for mediastinal reoperation, was 64%. Arteriography alone provided accurate preoperative localization...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::This retrospective study evaluated quantification of skin fluorescein delivery by fiberoptic fluorometry as a means of predicting the healing potential of an amputation site. Fluorometry uses a dual-channel fiberoptic light guide--one channel transmits blue light to excite the fluorescein in the skin under study, and ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::Prevention of ischemic bowel complications following abdominal aortic reconstruction requires identification of the patient at high risk for developing the complication; on precise, gentle, meticulous operative technique; on knowledge of bowel blood supply; on determining when the IMA must be reconstructed or when it ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Previous studies using simulation-based curricula have focused largely on technical skills. We developed a set of simulation-based modules that focus on intraoperative decision making. The objective of this study was to conduct a faculty evaluation of: (1) the usefulness of 4 newly developed, simulation-base...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.10.010
更新日期:2011-04-01 00:00:00