Abstract：
BACKGROUND:Benign thyroid cysts have been successfully treated with nonoperative sclerotherapy. Although OK-432 is a safe and effective sclerosing agent used to treat benign cystic lesions, little is known about its effectiveness in thyroid cysts. This study tested the efficacy of OK-432 sclerotherapy for thyroid cysts. METHODS:This was a prospective cohort study of 45 consecutive patients with benign thyroid cysts, as assessed by ultrasound (US)-guided biopsy. After evacuation, about 50% of the aspirated fluid volume was replaced with saline solution containing 0.1 to 0.2 mg OK-432. Recurrences were treated by repeat treatments, to a maximum of 3. Outcome was cyst volume on US 6 months after the last treatment. RESULTS:Median pretreatment cyst volume was 15 mL (range, 3.5-110). Of the 45 patients, 33 (73%) were cured, defined as a residual cyst volume <1 mL; 20 were cured after 1 treatment, 8 after 2 treatments, and 5 after 3 treatments. Of the 12 patients (27%) not cured, 7 had >50% of the original cyst volume and 5 had <50% volume reduction; 3 of these patients underwent hemithyroidectomy. Multivariate analysis showed that the chance of success decreased with the number of previous aspirations and with increased cyst volume (P < .015 each). Transient mild local pain and low-grade fever were observed in 26 (58%) and 19 (42%) patients, respectively, but there were no significant treatment-related complications. CONCLUSIONS:Intracystic injection of OK-432 may be a safe and effective treatment for benign thyroid cysts.
journal_name
Surgeryjournal_title
Surgeryauthors
Roh JL,Park C 2nddoi
10.1016/j.surg.2008.06.014subject
Has Abstractpub_date
2008-11-01 00:00:00pages
775-9issue
5eissn
0039-6060issn
1532-7361pii
S0039-6060(08)00405-4journal_volume
144pub_type
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